Hostname: page-component-754f97d4cd-s7cr6 Total loading time: 0 Render date: 2026-07-28T16:26:02.483Z Has data issue: false hasContentIssue false
  • English
  • Français

Necrobiotic xanthogranuloma of the parotid gland

Published online by Cambridge University Press:  14 October 2009

A Zainal ,
M Y Razif ,
M Makhashen ,
M Swaminathan  and
A Mazita
A Zainal*
Affiliation:
Department of Otorhinolaryngology – Head and Neck Surgery, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia
M Y Razif
Affiliation:
Department of Otorhinolaryngology – Head and Neck Surgery, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia
M Makhashen
Affiliation:
Department of Pathology, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia
M Swaminathan
Affiliation:
Department of Pathology, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia
A Mazita
Affiliation:
Department of Otorhinolaryngology – Head and Neck Surgery, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia
*
Address for correspondence: Dr A Zainal, Department of Otorhinolaryngology – Head and Neck Surgery, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, 56000 Cheras, Kuala Lumpur, Malaysia. Fax: 603 91737840 E-mail: azidazainal@gmail.com
Get access Rights & Permissions [Opens in a new window]

Abstract

Objectives:

To highlight the first reported case of necrobiotic xanthogranuloma of the parotid gland. We also review the clinical presentations and treatments for this rare condition.

Method:

Case report and review of necrobiotic xanthogranuloma.

Results:

A 48-year-old man presented with a right parotid mass. Fine needle aspiration cytology was suggestive of Warthin's tumour, for which the patient underwent a subtotal parotidectomy. The final histopathological diagnosis was necrobiotic xanthogranuloma.

Conclusions:

Necrobiotic xanthogranuloma may clinically mimic commoner tumours such as Warthin's tumour. Once diagnosed, the clinician should be wary of extracutaneous manifestations and paraproteinaemias. Because of the variability of presentation, there is no consensus on the best treatment for necrobiotic xanthogranuloma, which may include surgery, chemotherapy, interferon, plasmapheresis and radiation therapy.

Keywords

XanthogranulomaParotid

Information

Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 124 , Issue 5 , May 2010 , pp. 569 - 571
Copyright
Copyright © JLO (1984) Limited 2009

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

1Finan, MC, Winklemann, RK. Necrobiotic xanthogranuloma with paraproteinaemia. A review of 22 cases. Medicine 1986;65:376–88CrossRefGoogle Scholar
2Moschella, SL. An update of the benign proliferative monocyte-macrophage and dendritic cell disorders. J Dermatol 1996;23:805–15CrossRefGoogle ScholarPubMed
3Mehregan, DA, Winklemann, RK. Necrobiotic xanthogranuloma. Arch Dermatol 1992;128:94–100CrossRefGoogle ScholarPubMed
4Sivak-Callcott, JA, Rootman, J, Rasmussen, SL, Nugent, RA, White, VA, Paridaens, D et al. Adult xanthogranulomatous disease of the orbit and ocular adnexa: new immunohistochemical findings and clinical review. Br J Ophthalmol 2006;90:602–8CrossRefGoogle ScholarPubMed
5Chave, TA, Hutchinson, PE. Necrobiotic xanthogranuloma with two monoclonal paraproteins and no periorbital involvement at presentation. Clin Exp Dermatol 2001;26:493–6CrossRefGoogle ScholarPubMed
6Martinez Fernandez, M, Rodriguez Prieto, MA, Ruiz Gonzalez, I, Sanchez Sambucety, P, Delgado Vicente, S. Necrobiotic xanthogranuloma associated with myeloma. J Eur Acad Dermatol Venereol 2004;18:328–31CrossRefGoogle ScholarPubMed
7Finan, MC, Winkelmann, RK. Histopathology of necrobiotic xanthogranuloma with paraproteinaemia. J Cutan Pathol 1987;14:92–9CrossRefGoogle Scholar
8Machado, S, Alves, R, Lima, M, Leal, I, Massa, A. Cutaneous necrobiotic xanthogranuloma (NXG) successfully treated with low dose chlorambucil. Eur J Dermatol 2001;11:458–62Google ScholarPubMed
9Meyer, S, Szeimies, RM, Landthaler, M, Hohenleutner, S. Cyclophosphamide-dexamethasone pulsed therapy for treatment of recalcitrant necrobiotic xanthogranuloma with paraproteinaemia and ocular involvement. Br J Dermatol 2005;153:443–5CrossRefGoogle ScholarPubMed
10Venencie, PY, Le Bras, P, Toan, ND, Tchernia, G, Delfraissy, JF. Recombinant interferon alfa-2b treatment of necrobiotic xanthogranuloma with paraproteinaemia. J Am Acad Dermatol 1995;32:666–7CrossRefGoogle Scholar
11Georgiou, S, Monastirli, A, Kapranos, N, Pasmatzi, E, Sakkis, T, Tsambaos, D. Interferon alpha-2a monotherapy for necrobiotic xanthogranuloma. Acta Derm Venereol 1999;24:484–9CrossRefGoogle Scholar
12Finelli, LG, Ratz, JL. Plasmapheresis: a treatment modality for necrobiotic xanthogranuloma. J Am Acad Dermatol 1987;17:351–4CrossRefGoogle ScholarPubMed
13Elner, VM, Mintz, R, Demirci, H, Hassan, AS. Local corticosteroid treatment of eyelid and orbital xanthogranuloma. Ophthal Plast Reconstr Surg 2006;22:36–40CrossRefGoogle ScholarPubMed
14Cocco, AE, MacLennan, GT, Lavertu, P, Wasman, JK. Xanthogranulomatous sialadenitis: a case report and literature review. Ear Nose Throat J 2005;84:369–70CrossRefGoogle ScholarPubMed