Hostname: page-component-5db58dd55d-h5th4 Total loading time: 0 Render date: 2026-06-01T02:22:32.386Z Has data issue: false hasContentIssue false
  • English
  • Français

Is injectable collagen truly safe?

Published online by Cambridge University Press:  29 June 2007

Etsuyo Takayama ,
Makoto Ikeda ,
Sumiaki Tsuru ,
Masami Ogura ,
Satoshi Kitahara ,
Tetsuzo Inouye  and
Gerald B. Healy
Etsuyo Takayama*
Affiliation:
Departments of Otolaryngology, National Defense Medical College, Tokorozawa, Saitama, Japan.
Makoto Ikeda*
Affiliation:
Departments of Otolaryngology, National Defense Medical College, Tokorozawa, Saitama, Japan.
Sumiaki Tsuru
Affiliation:
Department of Microbiology, National Defense Medical College, Tokorozawa, Saitama, Japan.
Masami Ogura
Affiliation:
Departments of Otolaryngology, National Defense Medical College, Tokorozawa, Saitama, Japan.
Satoshi Kitahara
Affiliation:
Departments of Otolaryngology, National Defense Medical College, Tokorozawa, Saitama, Japan.
Tetsuzo Inouye
Affiliation:
Departments of Otolaryngology, National Defense Medical College, Tokorozawa, Saitama, Japan.
Gerald B. Healy
Affiliation:
Department of Otology and Laryngology, Havard Medical School, Boston, USA.
*
Dr Etsuyo Takayama and Dr Makoto Ikeda, Department of Otolaryngology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359, Japan
Dr Etsuyo Takayama and Dr Makoto Ikeda, Department of Otolaryngology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359, Japan
Get access Rights & Permissions [Opens in a new window]

Abstract

Most patients have no response to injectable collagen or silicone, but some cases may have positive or ‘undersea’(= clinically negative but immunologically positive) response to collagen. From the results of the Macrophage migration inhibition test, the relative immunogenicity was augmented most when we used implants with the following combination. The firstimmunization was collagen and the second one was collagen with silicone.

The augmented antigenicity might be enough to cause an allergic reaction to the patients who had no response to each implant alone. The purpose of this article is to warn of the potential hazard of injection.

Keywords

InjectioncollagenSilicone

Information

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 106 , Issue 8 , August 1992 , pp. 704 - 708
Copyright
Copyright © JLO (1984) Limited 1992

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

Charriere, G., Bejot, M., Schnitzler, L., Ville, G., Hartmann, D. J. (1989) Reactions to a bovine collagen implant. Journal of the American Academy of Dermatology, 21: 6: 1203–1208.CrossRefGoogle ScholarPubMed
Cooperman, L., Michaeli, D. (1984) The immunogenicity of injectable collagen. II. A retrospective review of 72 tested and treated patients. Journal of the American Academy of Dermatology, 10: 647–651.CrossRefGoogle Scholar
DeLustro, R., Condell, R. A., Nguyen, M. A., McPherson, J. M. (1986) A comparative study of the biologic and immunologic response to medical devices derived from dermal collagen. Journal of Biomedical Materials Research, 20: 109–120.CrossRefGoogle ScholarPubMed
George, M., Vaughan, J. H. (1962) In vitro cell migration as a model for delayed hypersensitivity. Proceeding of the Society of Experimental Biological Medicine, 111: 514–521.CrossRefGoogle Scholar
Hinderer, U. T., Escalona, J. (1990) Dermal and subdermal tissue filling with fetal connective tissue and cartilage, collagen and silicone; experimental study in the pig compared with clinical results. A new technique of dermis mini-autograft injections. Aesthetic Plastic Surgery, 14: 239–248.CrossRefGoogle ScholarPubMed
McCoy, J. P., Schade, W., Siegle, R. J., Vanderveen, E. E., Zachary, C. B., Waldinger, T. P., Swanson, N. A. (1987) Immune response to bovine collagen implants. Journal of the American Academy of Dermatology, 16: 955–960.CrossRefGoogle ScholarPubMed
Nosanchuk, J. S. (1968) Silicone granuloma in breast. Archives of Surgery, 97: 583–585.CrossRefGoogle ScholarPubMed
Siegle, R. J., McCoy, J. P., Schade, W., Swanson, N. A. (1984) Intradermal implantation of bovine collagen. Archives of Dermatology, 120: 183–187.CrossRefGoogle ScholarPubMed
Takayama, E., Ikeda, M., Kitahara, S., Ogura, M., Fukuda, H., Inouye, T. (1991) Immuneresponse to injectable collagen. Otologia, 37: 1408–1413.Google Scholar
Winer, L. H., Sternberg, T. H., Lehman, R., Ashley, F. (1964) Tissue reactions to injected silicone liquids. Archives of Dermatology, 90: 588–593.CrossRefGoogle ScholarPubMed