Hostname: page-component-6766d58669-kl59c Total loading time: 0 Render date: 2026-05-18T05:22:14.929Z Has data issue: false hasContentIssue false
  • English
  • Français

Macrocytosis and sudden sensorineural hearing loss: a case report

Published online by Cambridge University Press:  23 September 2015

A E L McMurran  and
R A Adair
A E L McMurran*
Affiliation:
Department of Otolaryngology, Ulster Hospital, Belfast, Northern Ireland, UK
R A Adair
Affiliation:
Department of Otolaryngology, Ulster Hospital, Belfast, Northern Ireland, UK
*
Address for correspondence: Ms A E L McMurran, Department of Otolaryngology, Ulster Hospital, Upper Newtownards Road, Dundonald, Belfast BT16 1RH, Northern Ireland, UK E-mail: aelmcmurranacademic@gmail.com
Get access Rights & Permissions [Opens in a new window]

Abstract

Background:

Although other blood dyscrasias are known to cause sudden sensorineural hearing loss, macrocytosis has not previously been implicated in the absence of another causative agent.

Case report:

We present a case of bilateral sequential sudden sensorineural hearing loss in a patient with significant macrocytosis (mean corpuscular volume at presentation 124 fl) secondary to alcohol-induced liver dysfunction.

Conclusion:

A possible pathophysiological mechanism linking macrocytosis and sudden sensorineural hearing loss was identified, suggesting areas for further investigation.

Keywords

Hearing LossHearing Loss, SuddenHearing Loss, Sensorineural

Information

Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 129 , Issue 11 , November 2015 , pp. 1137 - 1139
Copyright
Copyright © JLO (1984) Limited 2015 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

Footnotes

Presented as an oral presentation at the Royal Academy of Medicine in Ireland Otolaryngology Winter Meeting, 12 December 2014, Dublin, Ireland

References

1Davidson, RJL, Hamilton, PJ. High mean red cell volume: its incidence and significance in routine haematology. J Clin Pathol 1978;31:493–8CrossRefGoogle ScholarPubMed
2Freeman, SRM, Bray, ME, Amos, CS, Gibson, WPR. The association of codeine, macrocytosis and bilateral sudden or rapidly progressive sensorineural deafness. Acta Otolaryngol 2009;129:1061–6CrossRefGoogle ScholarPubMed
3National Toxicology Program. NTP toxicology and carcinogenesis studies of codeine (CAS No. 76–57–3) in F344 rats and B6C3F1 mice (feed studies). Natl Toxicol Program Tech Rep Ser 1996;455:1–275Google Scholar
4Medicines and Healthcare Products Regulatory Agency. Drug Analysis Print. Drug Name: Codeine In: www.mhra.gov.uk/home/groups/public/documents/sentineldocuments/dap_1567153339489017.pdf [18 August 2015]Google Scholar
5Chung, SD, Chen, PY, Lin, HC, Hung, SH. Sudden sensorineural hearing loss associated with iron-deficiency anaemia: a population based study. JAMA Otolaryngol Head Neck Surg 2014;140:417–22CrossRefGoogle ScholarPubMed
6Lee, EJ, Yoon, YJ. Bilateral sudden sensorineural hearing loss as an initial presentation of myelodysplastic syndrome. Am J Otolaryngol 2012;33:782–3CrossRefGoogle ScholarPubMed
7Bay, A, Keskin, M, Hizli, S, Uygun, H, Dai, A, Gumruk, F. Thiamine-responsive megaloblastic anaemia syndrome. Int J Hematol 2010;92:524–6CrossRefGoogle Scholar
8Vaya, A, Bonet, E, Romagnoli, M, Nunez, C, Todoli, J. Erythrocyte deformability in macrocytosis determined by means of ektacytometry techniques. Clin Hemorheol Micro 2010;45:27–33Google ScholarPubMed
9Garcia-Callejo, FJ, Marco-Algarra, J, Pla-Gil, I, Monzo-Gandia, R, Juantegui-Azpilicueta, M, Martinez-Beneyto, P. Pathologic erythrocyte deformability in patients with sudden sensorineural hearing loss. Acta Otorrinolaringol Esp 2012;63:249–57Google ScholarPubMed
10Ueda, T, Kawakami, R, Horii, M, Sugawara, Y, Matsumoto, T, Okada, S et al. High Mean Corpuscular Volume is a new indicator of prognosis in acute decompensated heart failure. Circ J 2013;77:2766–71CrossRefGoogle ScholarPubMed
11Tennankore, KK, Soroka, SD, Kiberd, BA. Macrocytosis may be associated with mortality in chronic hemodialysis patients: a prospective study. BMC Nephrol 2011;12:19CrossRefGoogle ScholarPubMed
12Myojo, M, Iwata, H, Kohro, T, Sato, H, Kiyosue, A, Ando, J. Prognostic implication of macrocytosis on adverse outcomes after coronary intervention. Atherosclerosis 2012;221:148–53CrossRefGoogle ScholarPubMed
13Sara, SA, The, BM, Friedland, P. Bilateral sudden sensorineural hearing loss: review. J Laryngol Otol 2014;128:S8–S15CrossRefGoogle ScholarPubMed