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Intranasal Helicobacter pylori infection in patients with chronic rhinosinusitis with polyposis

Published online by Cambridge University Press:  03 August 2018

N Siupsinskiene ,
I Katutiene ,
V Jonikiene ,
D Janciauskas  and
S Vaitkus
N Siupsinskiene*
Affiliation:
Faculty of Health Sciences, Klaipeda University, Lithuania Department of Otolaryngology, Academy of Medicine, Lithuanian University of Health Sciences, Kaunas, Lithuania
I Katutiene
Affiliation:
Department of ENT, Klaipeda Republic Hospital, Lithuania
V Jonikiene
Affiliation:
Department of ENT, Klaipeda Republic Hospital, Lithuania
D Janciauskas
Affiliation:
Department of Pathologic Anatomy, Academy of Medicine, Lithuanian University of Health Sciences, Kaunas, Lithuania
S Vaitkus
Affiliation:
Department of Otolaryngology, Academy of Medicine, Lithuanian University of Health Sciences, Kaunas, Lithuania
*
Author for correspondence: Habil. Dr Nora Siupsinskiene, Department of Otolaryngology, Academy of Medicine, Lithuanian University of Health Sciences, Eiveniu 2, Kaunas LT-50009, Lithuania E-mail: norai_s@yahoo.com Fax: +370 37 326862
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Abstract

Objective

To determine the prevalence of Helicobacter pylori infection in nasal biopsy specimens from patients with chronic rhinosinusitis with polyposis versus control patients, and to assess the correlations between H pylori infection identified in the nasal tissue and patients’ sociodemographic data and reflux-related symptoms and signs.

Methods

Nasal biopsy samples were taken from 75 adult patients who underwent nasal surgery for chronic rhinosinusitis with polyposis (clinical group, n = 45) and a deviated septum (control group, n = 30). H pylori infection was identified using histochemical and rapid urease tests.

Results

The prevalence of intranasal H pylori infection was significantly higher in the clinical group (28.9 per cent) compared to the control group (3.3 per cent) (p = 0.005). A significant yet weak association was found between positive H pylori status and laryngopharyngeal reflux related hypertrophy of the posterior commissure of the larynx. No other correlations reached statistical significance.

Conclusion

H pylori infection is potentially related to chronic rhinosinusitis with polyposis. Further research is needed to clarify the role of H pylori as a risk factor for the development of sinonasal diseases and to examine its link with laryngopharyngeal reflux.

Keywords

Helicobacter PyloriSinusitisNasal PolypsLaryngopharyngeal Reflux

Information

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 132 , Issue 9 , September 2018 , pp. 816 - 821
Copyright
Copyright © JLO (1984) Limited, 2018 

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Footnotes

Habil. Dr N Siupsinskiene takes responsibility for the integrity of the content of the paper

References

1Ozdek, A, Cirak, MY, Samim, E, Bayiz, U, Safak, MA, Turet, S. A possible role of Helicobacter pylori in chronic rhinosinusitis: a preliminary report. Laryngoscope 2003;113:679–82Google Scholar
2Kariya, S, Okano, M, Nishizaki, K. An association between Helicobacter pylori and upper respiratory tract disease: fact or fiction? World J Gastroenterol 2014;20:1470–84Google Scholar
3Yemisen, M, Mete, B, Kanbay, A, Balkan, II, Ozaras, R. The role of Helicobacter pylori in upper respiratory system infections: is it more than colonization? Curr Infect Dis Rep 2012;14:128–36Google Scholar
4Kurtaran, H, Uyar, ME, Kasapoglu, B, Turkay, C, Yilmaz, T, Akcay, A et al. Role of Helicobacter pylori in pathogenesis of upper respiratory system diseases. J Natl Med Assoc 2008;100:1224–30Google Scholar
5Siupsinskiene, N, Katutiene, I, Jonikiene, V, Janciauskas, D, Vaitkus, S. Helicobacter pylori in the tonsillar tissue: a possible association with chronic tonsillitis and laryngopharyngeal reflux. J Laryngol Otol 2017;131:549–56Google Scholar
6Siupsinskiene, N, Jurgutaviciute, V, Katutiene, I, Janciauskas, D, Vaitkus, S, Adamonis, K. Helicobacter pylori infection in laryngeal diseases. Eur Arch Otorhinolaryngol 2013;270:2283–8Google Scholar
7Malfertheiner, P, Megraud, F, O'Morain, CA, Gilbert, JP, Kuipers, EJ, Axon, AT et al. Management of Helicobacter pylori infection—the Maastricht V/Florence Consensus Report. Gut 2017;66:6–30Google Scholar
8Hagymási, K, Tulassay, Z. Helicobacter pylori infection: new pathogenetic and clinical aspects. World J Gastroenterol 2014;20:6386–99Google Scholar
9Katra, R, Kabelka, Z, Jurovcik, M, Hradsky, O, Kraus, J, Pavlik, E et al. Pilot study: association between Helicobacter pylori in adenoid hyperplasia and reflux episodes detected by multiple intraluminal impedance in children. Int J Pediatr Otorhinolaryngol 2014;78:1243–9Google Scholar
10Morinaka, S, Ichimiya, M, Nakamura, H. Detection of Helicobacter pylori in nasal and maxillary sinus specimens from patients with chronic sinusitis. Laryngoscope 2003;113:1557–63Google Scholar
11Bansal, D, Sharma, S, Agarwal, S, Saha, RN. Detection of Helicobacter pylori in nasal polyps. Head Neck Pathol 2016;10:306–13Google Scholar
12Belafsky, PC, Postma, GN, Amin, MR, Koufman, JA. Symptoms and findings of laryngopharyngeal reflux. Ear Nose Throat J 2002;81:10–13Google Scholar
13Belafsky, PC, Postma, GN, Koufman, JA. The validity and reliability of the Reflux Finding Score (RFS). Laryngoscope 2001;111:1313–17Google Scholar
14Jančiauskas, D. Histomorphological Changes of Gastric Mucosa in Functional Dyspepsia Patients and their Dynamics after Treatment with the Natural Antioxidant Astaxanthin. Kaunas: Kaunas Medical University, 2010Google Scholar
15Tseng, CA, Wang, WM, Wu, DC. Comparison of the clinical feasibility of three rapid urease tests in the diagnosis of Helicobacter pylori infection. Dig Dis Sci 2000;50:449–52Google Scholar
16Cvorovic, L, Brajovic, D, Strbac, M, Milutinovic, Z, Cvorovic, V. Detection of Helicobacter pylori in nasal polyps: preliminary report. J Otolaryngol Head Neck Surg 2008;37:192–5Google Scholar
17Koc, C, Arikan, OK, Atasoy, P, Aksoy, A. Prevalence of Helicobacter pylori in patients with nasal polyps: a preliminary report. Laryngoscope 2004;114:1941–4Google Scholar
18Včeva, A, Danić, D, Včev, A, Birtiċ, D, Mikalj, H, Zubčiċ, et al. The significance of Helicobacter pylori in patients with nasal polyposis. Med Glas (Zenica) 2012;9:281–6Google Scholar
19Noorbakhsh, S, Tabatabaei, A, Farhadi, M, Shamshiri, AR. Helicobacter pylori-DNA in nasal polyp tissues in compare with inferior nasal turbinate tissues: a case-control study in Tehran, Iran. J Infect Dis Immun 2011;3:73–8Google Scholar
20Burduk, PK, Kaczmarek, A, Budzynska, A, Kazmierczak, W, Gospodarek, E. Detection of Helicobacter pylori and cagA gene in nasal polyps and benign laryngeal diseases. Arch Med Res 2011;42:686–9Google Scholar
21Nikakhlagh, S, Samarbafzadeh, AR, Jahani, M, Poostchi, H, Kayedani, GA, Naghashpoor, M et al. Determining the role of Helicobacter pylori in chronic sinus infections using the polymerase chain reaction. Jundishapur J Microbiol 2015;8:e20783Google Scholar
22Jelavic, B, Grgić, M, Cupić, H, Kordić, M, Vasilj, M, Baudoin, T. Prognostic value of Helicobacter pylori sinonasal colonization for efficacy of endoscopic sinus surgery. Eur Arch Otorhinolaryngol 2012;269:2197–202Google Scholar
23Rook, GA. The changing microbial environment and chronic inflammatory disorders. Allergy Asthma Clin Immunol 2008;4:117–24Google Scholar
24Ozyurt, M, Gungor, A, Ergunay, K, Cekin, E, Erkul, E, Haznedaroglu, T. Real-time PCR detection of Helicobacter pylori and virulence-associated cagA in nasal polyps and laryngeal disorders. Otolaryngol Head Neck Surg 2009;141:131–5Google Scholar
25Dinis, PB, Subtil, J. Helicobacter pylori and laryngopharyngeal reflux in chronic rhinosinusitis. Otolaryngol Head Neck Surg 2006;134:67–72Google Scholar
26Sella, GC, Tamashiro, E, Anselmo-Lima, WT, Valera, FC. Relation between chronic rhinosinusitis and gastroesophageal reflux in adults: systematic review. Braz J Otorhinolaryngol 2017;83:356–63Google Scholar
27Wong, IW, Omari, TI, Myers, JC, Rees, G, Nair, SB, Jamieson, GG et al. Nasopharyngeal pH monitoring in chronic sinusitis patients using a novel four channel probe. Laryngoscope 2004;114:1582–5Google Scholar
28Campbell, R, Kilty, SJ, Hutton, B, Bonaparte, JP. The role of Helicobacter pylori in laryngopharyngeal reflux. Otolaryngol Head Neck Surg 2017;156:255–62Google Scholar
29DelGaudio, JM. Direct nasopharyngeal reflux of gastric acid is a contributing factor in refractory chronic rhinosinusitis. Laryngoscope 2005;115:946–57Google Scholar
30Nemati, S, Mojtahedi, A, Naghavi, SE, Banan, R, Zia, F. Investigating Helicobacter pylori in nasal polyposis using polymerase chain reaction, urease test and culture. Eur Arch Otorhinolaryngol 2012;269:1457–61Google Scholar