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Effect of antioxidants on the clinical outcome of patients with nasal polyposis

Published online by Cambridge University Press:  14 June 2011

M Sagit ,
H Erdamar ,
C Saka ,
S Yalcin  and
I Akin
M Sagit*
Affiliation:
Department of ENT, Kayseri Training and Research Hospital, Kayseri, Turkey
H Erdamar
Affiliation:
Department of Medical Biochemistry, Tunceli Government Hospital, Tunceli, Turkey
C Saka
Affiliation:
Department of ENT, Dıskapi Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey
S Yalcin
Affiliation:
Department of Anesthesiology, Harran University School of Medicine, Sanliurfa, Turkey
I Akin
Affiliation:
Department of ENT, Dıskapi Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey
*
Address for correspondence: Dr Mustafa Sagit, ENT Department, Kayseri Eğitim ve Araştırma Hastanesi KBB KliniğiSanayi Mah. Atatürk Bulvarı Hastane Cad. No: 78 38010, Kayseri, Turkey Fax: +90 352 320 73 13 E-mail: musagit@yahoo.com
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Abstract

Aim:

To investigate the therapeutic effects of antioxidants on the clinical and biochemical outcome of patients with nasal polyposis.

Methods:

Thirty-four patients with nasal polyposis were divided into two groups receiving either intranasal steroid or intranasal steroid plus per-oral vitamins A, C and E and selenium. Paranasal sinus computed tomography, endoscopy, and polyp tissue and serum sampling were conducted pre- and post-therapy. Serum levels of malondialdehyde, superoxide dismutase, nitrite and myeloperoxidase and tissue levels of malondialdehyde and superoxide dismutase were measured. Group results were compared using the Mann–Whitney U test and Wilcoxon signed-rank test.

Results:

Both groups had significantly lower tissue parameters, computed tomography scores and serum malondialdehyde levels, comparing pre- versus post-treatment results. Post-treatment, the steroid plus antioxidant group had significantly lower tissue malondialdehyde levels and a greater fall in tissue and serum malondialdehyde, compared with the steroid group.

Conclusion:

Serum and tissue levels of malondialdehyde (an oxidative marker) were significantly decreased by adding antioxidants to standard therapy. This is the first report of the positive effects of adding antioxidants to steroid therapy for nasal polyposis.

Keywords

Nasal PolypsOxidative StressAntioxidantsPathologyTherapeutics

Information

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 125 , Issue 8 , August 2011 , pp. 811 - 815
Copyright
Copyright © JLO (1984) Limited 2011

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References

1Karlidağ, T, Ilhan, N, Kaygusuz, I, Keles, E, Yalçin, S, Yildiz, M. Roles of free radicals, nitric oxide, and scavenging enzymes in nasal polyp development. Ann Otol Rhinol Laryngol 2005;114:122–6CrossRefGoogle ScholarPubMed
2Doğru, H, Delibaş, N, Döner, F, Tüz, M, Uygur, K. Free radical damage in nasal polyp tissue. Otolaryngol Head Neck Surg 2001;124:570–2CrossRefGoogle ScholarPubMed
3Dağlı, M, Eryilmaz, A, Besler, T, Akmansu, H, Acar, A, Korkmaz, H. Role of free radicals and antioxidants in nasal polyps. Laryngoscope 2004;114:1200–3CrossRefGoogle ScholarPubMed
4Uneri, C, Oztürk, O, Polat, S, Yüksel, M, Haklar, G, Bozkurt, S et al. Determination of reactive oxygen species in nasal polyps. Rhinology 2005;43:185–9Google ScholarPubMed
5Taysi, S, Uslu, C, Yilmaz, A, Aktan, B, Altas, E. Lipid peroxidation and some antioxidant enzymes in nasal polyp tissue. Cell Biochem Funct 2006;24:461–5CrossRefGoogle ScholarPubMed
6Okur, E, Inanc, F, Yildirim, I, Kilinc, M, Kilic, MA. Malondialdehyde level and adenosine deaminase activity in nasal polyps. Otolaryngol Head Neck Surg 2006;134:37–40CrossRefGoogle ScholarPubMed
7Cheng, YK, Hwang, GY, Lin, CD, Tsai, MH, Tsai, SW, Chang, WC. Altered expression profile of superoxide dismutase isoforms in nasal polyps from nonallergic patients. Laryngoscope 2006;116:417–22CrossRefGoogle ScholarPubMed
8Cekin, E, Ipcioglu, OM, Erkul, BE, Kapucu, B, Ozcan, O, Cincik, H et al. The association of oxidative stress and nasal polyposis. J Int Med Res 2009;37:325–30CrossRefGoogle ScholarPubMed
9Giannessi, F, Ursino, F, Fattori, B, Giambelluca, MA, Scavuzzo, MC, Nacci, A et al. Expression of 3-nitrotyrosine, a marker for peroxynitrite, in nasal polyps of nonatopic patients. Med Sci Monit 2010;16:172–9Google ScholarPubMed
10Woo, HJ, Bae, CH, Song, SY, Kim, YW, Lee, HM, Kim, YD. Expression of glutaredoxin-1 in nasal polyps and airway epithelial cells. Am J Rhinol Allergy 2009;23:288–93CrossRefGoogle ScholarPubMed
11Bugdayci, G, Kaymakci, M. Nitrite/nitrate and malondialdehyde levels in nasal polyp. Cell Mol Biol (Noisy-le-grand) 2008;54:1043–5Google ScholarPubMed
12Kang, BH, Huang, NC, Wang, HW. Possible involvement of nitric oxide and peroxynitrite in nasal polyposis. Am J Rhinol 2004;18:191–6CrossRefGoogle ScholarPubMed
13Halliwell, B. Oxidants and human disease: some new concepts. FASEB J 1987;1:358–64CrossRefGoogle ScholarPubMed
14Döner, F, Delibaş, N, Doğru, H, Sari, I, Yorgancigil, B. Malondialdehyde levels and superoxide dismutase activity in experimental maxillary sinusitis. Auris Nasus Larynx 1999;26:287–91CrossRefGoogle ScholarPubMed
15Cross, CE, Halliwell, B, Borish, ET, Pryor, WA, Ames, BN, Saul, RL et al. Oxygen radicals and human disease. Ann Intern Med 1987;107:526–45CrossRefGoogle ScholarPubMed
16Halliwell, B, Gutteridge, JM, Cross, CE. Free radicals, antioxidants, and human disease: where are we now? J Lab Clin Med 1992;119:598–620Google ScholarPubMed
17Rasp, G, Kramer, MF, Ostertag, P, Kastenbauer, E. A new system for the classification of ethmoid polyposis. Effect of combined local and systemic steroid therapy [in German]. Laryngorhinootologie 2000;79:266–72CrossRefGoogle ScholarPubMed
18Yoshioka, T, Kawada, K, Shimada, T, Mori, M. Lipid peroxidation in maternal and cord blood and protective mechanisms against activated oxygen toxicity in the blood. Am J Obstet Gynecol 1979;135:372–6CrossRefGoogle ScholarPubMed
19Mihara, M, Uchiyama, M. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal Biochem 1978;86:271–8Google ScholarPubMed
20Sun, Y, Oberley, LW, Li, Y. A simple method for clinical assay of superoxide dismutase. Clin Chem 1988;34:497–500CrossRefGoogle ScholarPubMed
21Glowick, SP. Methods in Enzymology. New York: Academic Press, 1955Google Scholar
22Green, LC, Wagner, DA, Glogowski, J, Skipper, PL, Wishnok, JS, Tannenbaum, SR. Analysis of nitrate, nitrite, and [15N] nitrate in biological fluids. Anal Biochem 1982;126:131–8CrossRefGoogle ScholarPubMed
23Gopalakrishna, R, Jaken, S. Protein kinase C signaling and oxidative stress. Free Radic Biol Med 2000;28:1349–61CrossRefGoogle ScholarPubMed
24Kaygusuz, I, Ilhan, N, Karlidag, T, Keles, E, Yalçin, S, Cetiner, H. Free radicals and scavenging enzymes in chronic tonsillitis. Otolaryngol Head Neck Surg 2003;129:265–8CrossRefGoogle ScholarPubMed
25Shigemi, H, Egashira, T, Kurono, Y, Mogi, G. Role of superoxide dismutase in otitis media with effusion. Ann Otol Rhinol Laryngol 1998;107:327–31CrossRefGoogle ScholarPubMed
26Halliwell, B. Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? Lancet 1994;344:721–4CrossRefGoogle ScholarPubMed
27Cochrane, CG. Mechanisms of oxidant injury of cells. Mol Aspects Med 1991;12:137–47CrossRefGoogle ScholarPubMed
28Norlander, T, Westrin, KM, Fukami, M, Stierna, P, Carlsöö, B. Experimentally induced polyps in the sinus mucosa: a structural analysis of the initial stages. Laryngoscope 1996;106:196–203CrossRefGoogle ScholarPubMed
29Rasp, G, Bujía, J. Treatment of nasal polyposis with systemic and local corticoids [in Spanish]. Acta Otorrinolaringol Esp 1997;48:37–40Google ScholarPubMed
30Machlin, LJ, Bendich, A. Free radical tissue damage: protective role of antioxidant nutrients. FASEB J 1987;1:441–5CrossRefGoogle ScholarPubMed