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External Validation of the National Healthcare Safety Network Risk Models for Surgical Site Infections in Total Hip and Knee Replacements

Published online by Cambridge University Press:  10 May 2016

Laura W. Lewallen ,
Hilal Maradit Kremers ,
Brian D. Lahr ,
Tad M. Mabry ,
James M. Steckelberg ,
Daniel J. Berry ,
Arlen D. Hanssen ,
Elie F. Berbari  and
Douglas R. Osmon
Laura W. Lewallen
Affiliation:
Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota
Hilal Maradit Kremers*
Affiliation:
Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota
Brian D. Lahr
Affiliation:
Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota
Tad M. Mabry
Affiliation:
Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota
James M. Steckelberg
Affiliation:
Department of Medicine, Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota
Daniel J. Berry
Affiliation:
Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota
Arlen D. Hanssen
Affiliation:
Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota
Elie F. Berbari
Affiliation:
Department of Medicine, Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota
Douglas R. Osmon
Affiliation:
Department of Medicine, Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota
*
Mayo Clinic, 200 First Street SW, Rochester, MN 55905 (maradit@mayo.edu).
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Abstract

Background.

The National Healthcare Safety Network surgical site infections risk models for hip (HPRO) and knee (KPRO) replacement are intended for case-mix adjustment when reporting surgical site infection rates across institutions, but they are not validated in external data sets

Objective.

To evaluate the validity of HPRO and KPRO risk models and improvement in risk prediction with inclusion of information on morbid obesity and diabetes mellitus.

Design.

Retrospective cohort study.

Patients.

A single-center cohort of 21,941 hip and knee replacement procedures performed between 2002 and 2009.

Methods.

Discriminative ability was assessed using the concordance statistic (C statistic). Calibration was assessed using the Hosmer-Lemeshow goodness-of-fit tests.

Results.

The discrimination of HPRO was good, with a C statistic of 0.695 for surgical site infections and 0.749 for prosthetic joint infections. The discrimination of KPRO was worse than that of HPRO, with a C statistic of 0.592 for surgical site infections and 0.675 for prosthetic joint infections. Adding morbid obesity and diabetes mellitus to the HPRO and KPRO risk models modestly improved discrimination. There was no significant evidence of miscalibration based on the Hosmer-Lemeshow tests, but calibration of HPRO models appeared to be better than that of the KPRO models.

Conclusions.

HPRO performed better than the KPRO in predicting surgical site infections after hip and knee replacements. Both fared well in predicting prosthetic joint infections.

Infect Control Hosp Epidemiol 2014;35(11):1323–1329

Information

Type
Original Article
Information
Infection Control & Hospital Epidemiology , Volume 35 , Issue 11 , November 2014 , pp. 1323 - 1329
Copyright
© 2014 by The Society for Healthcare Epidemiology of America. All rights reserved.

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