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Significance of immunohistochemical overexpression of cyclooxygenase-2 in overall and disease-free survival of oral squamous cell carcinoma patients

Published online by Cambridge University Press:  24 January 2019

S M Adnan Ali ,
S Naeem ,
Y Mirza ,
N Zahid  and
M S Awan
S M Adnan Ali*
Affiliation:
Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan
S Naeem
Affiliation:
Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan
Y Mirza
Affiliation:
Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan
N Zahid
Affiliation:
Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan
M S Awan
Affiliation:
Section of Otolaryngology – Head and Neck Surgery, Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan
*
Author for correspondence: Dr Syed Muhammad Adnan Ali, Department of Surgery, Aga Khan University Hospital, Stadium Road, PO Box 3500, Karachi 74800, Pakistan E-mail: syed.adnan@aku.edu Fax: +92 21 3493 4294
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Abstract

Objective

In Pakistan, oral cancer ranks as the most common malignancy in males and the second most common malignancy in females. Cyclooxygenase-2 has been explored as an agent of carcinogenesis in oral and other neoplasms. This study aimed to observe the expression of cyclooxygenase-2 in oral squamous cell carcinoma, and to correlate the expression with patients’ clinical features and overall and disease-free survival.

Methods

Immunohistochemistry for cyclooxygenase-2 was performed on a total of 100 oral squamous cell carcinoma formalin-fixed, paraffin-embedded blocks. Expression was correlated with patients’ clinicopathological variables and overall and disease-free survival.

Results

Cyclooxygenase-2 was overexpressed in 55 per cent of oral squamous cell carcinoma patients. Overexpression was correlated with overall survival (p = 0.013) and disease-free survival (p = 0.001) on univariate analysis. However, on multivariate analysis, cyclooxygenase-2 was associated with only disease-free survival (p = 0.044) and not overall survival (p = 0.208).

Conclusion

Expression of cyclooxygenase-2 is associated with poorer overall survival and higher rates of recurrence in oral squamous cell carcinoma patients.

Keywords

Cyclooxygenase 2Oral CavityImmunohistochemistrySquamous Cell CarcinomaPrognosisDisease-Free Survival
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 132 , Issue 12 , December 2018 , pp. 1102 - 1109
Copyright
Copyright © JLO (1984) Limited, 2019 

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Footnotes

Dr S M Adnan Ali takes responsibility for the integrity of the content of the paper

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