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Hormonal changes causing rhinitis in pregnancy among Malaysian women

Published online by Cambridge University Press:  19 August 2013

B Indirani ,
R Raman  and
S Z Omar
B Indirani
Affiliation:
Department of Otorhinolaryngology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
R Raman*
Affiliation:
Department of Otorhinolaryngology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
S Z Omar
Affiliation:
Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
*
Address for correspondence: Professor Rajagopalan Raman, Department of Otorhinolaryngology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia Fax: +603 79556963 E-mail: ramanr_99@yahoo.com
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Abstract

Objectives:

To investigate the aetiology of rhinitis occurring in pregnancy, by (1) describing the relationship between pregnancy rhinitis and serum oestrogen, progesterone, placental growth hormone and insulin-like growth factor, and (2) assessing the prevalence of pregnancy rhinitis among Malaysian women.

Methods:

Prospective study involving 30 pregnant women followed at an ante-natal clinic for 14 months. Hormone levels were analysed during pregnancy and the post-partum period.

Results:

Levels of all four hormones were elevated in the third trimester, compared with first trimester and post-partum values. Rhinitis patients had higher levels of oestrogen and insulin-like growth factor 1 in the third trimester than non-rhinitis patients, although these differences were not statistically significant. The prevalence of rhinitis was 53.3 per cent, with most cases occurring in the third trimester. Patients with pregnancy rhinitis had a higher prevalence of female babies, compared with non-rhinitis patients (p = 0.003).

Conclusions:

Pregnancy rhinitis was significantly more common in women giving birth to female babies. Women with pregnancy rhinitis had a non-significant elevation in oestrogen and insulin-like growth factor 1 levels, compared with those without rhinitis.

Keywords

PregnancyRhinitisEstrogenProgesteronePlacental-Specific Growth HormoneHumanInsulin Like Growth Factor 1

Information

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 127 , Issue 9 , September 2013 , pp. 876 - 881
Copyright
Copyright © JLO (1984) Limited 2013 

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