Hostname: page-component-6766d58669-l4t7p Total loading time: 0 Render date: 2026-05-21T06:23:06.475Z Has data issue: false hasContentIssue false
  • English
  • Français

Configuration of experimentally produced cholesteatoma by transplantation of a free skin graft

Published online by Cambridge University Press:  29 June 2007

Kiyofumi Gyo ,
Yasushi Sasaki  and
Yasuyuki Hinohira
Kiyofumi Gyo*
Affiliation:
Department of Otolaryngology, Ehime University School of Medicine, Ehime, 791-02 Japan
Yasushi Sasaki
Affiliation:
Department of Otolaryngology, Ehime University School of Medicine, Ehime, 791-02 Japan
Yasuyuki Hinohira
Affiliation:
Department of Otolaryngology, Ehime University School of Medicine, Ehime, 791-02 Japan
*
Address for correspondence: Kiyofumi Gyo, Department of Otolaryngology, Ehime University School of Medicine, Ehime, 791-02 Japan. Fax: 0899-64-4613
Get access Rights & Permissions [Opens in a new window]

Abstract

Residual cholesteatoma was experimentally produced in guinea pigs by transplanting a free skin graft into the middle ear bulla. In group A, the graft was placed on the mucosa after scratching the surface with a pick, while in group B, it was placed on the bone surface following removal of the mucosa and drilling with a diamond burr. The group A procedure was conducted on the left ear and the group B procedure on the right ear in 12 guinea pigs. The animals were sacrificed at two, four and eight weeks after transplantation. In all 12 ears of group A, the graft kept its original flat shape, resembling an open type residue. In eight of 12 ears of group B, the graft grew forming a squamous pearl, while in the remaining four ears it retained a flat shape. The difference in configuration is thought to be due to the amount of granulation around the graft.

Keywords

CholesteatomaSkin transplantationGuinea pig

Information

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 110 , Issue 7 , July 1996 , pp. 629 - 631
Copyright
Copyright © JLO (1984) Limited 1996

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

Abramson, M., Asarch, R., Litton, W. (1975) Experimental aural cholesteatoma causing bone resorption. Annals of Otology, Rhinology and Laryngology 84: 425–432.CrossRefGoogle ScholarPubMed
Ahn, J. M., Huang, C., Abramson, M. (1990) Localization of interleukin 1 in human cholesteatoma. American Journal of Otolaryngology 11: 71–77.CrossRefGoogle ScholarPubMed
Jackson, D., Lim, D. (1978) Fine morphology of the advancing front of cholesteatoma-experimental and human. Acta Otolaryngologica 86: 71–88.CrossRefGoogle Scholar
Schilling, V., Negri, B., Bujia, J., Schulz, P., Kastenbauer, E. (1992) Possible role of interleukin α and interleukin 1 β in the pathogenesis of cholesteatoma of the middle ear. American Journal of Otology 13: 350–355.Google ScholarPubMed
Schulz, P., Bujia, J., Holly, A., Shilling, V., Kastenbauer, E. (1993) Possible autocrine growth stimulation of cholesteatoma pithelium by transforming growth factor alpha. American Journal of Otolaryngology 14: 82–87.CrossRefGoogle Scholar
Vennix, P. P. C. A., Kuijpers, W., Peters, T. A., Tonnaer, E. L. G. M., Ramaekers, F. C. S. (1994) Growth and differentiation of meatal skin grafts in the middle ear of the rat. Archives of Otolaryngology, Head and Neck Surgery 120: 1102–1111.CrossRefGoogle ScholarPubMed