Hostname: page-component-89b8bd64d-5bvrz Total loading time: 0 Render date: 2026-05-09T05:36:27.634Z Has data issue: false hasContentIssue false

Resilience and its association with hopelessness, depression, loneliness, post-traumatic stress disorder (PTSD) and suicidal ideations and behavior in a cohort in the Nairobi Metropolitan

Published online by Cambridge University Press:  11 March 2025

David M. Ndetei*
Affiliation:
Africa Institute of Mental and Brain Health (formerly Africa Mental Health Research and Training Foundation), Nairobi, Kenya Department of Psychiatry, University of Nairobi, Nairobi, Kenya World Psychiatric Association Collaborating Centre for Research and Training, Nairobi, Kenya
Victoria Mutiso
Affiliation:
Africa Institute of Mental and Brain Health (formerly Africa Mental Health Research and Training Foundation), Nairobi, Kenya World Psychiatric Association Collaborating Centre for Research and Training, Nairobi, Kenya
Christine Musyimi
Affiliation:
Africa Institute of Mental and Brain Health (formerly Africa Mental Health Research and Training Foundation), Nairobi, Kenya World Psychiatric Association Collaborating Centre for Research and Training, Nairobi, Kenya
Eric Jeremiah
Affiliation:
Africa Institute of Mental and Brain Health (formerly Africa Mental Health Research and Training Foundation), Nairobi, Kenya World Psychiatric Association Collaborating Centre for Research and Training, Nairobi, Kenya
Pascalyne Nyamai
Affiliation:
Africa Institute of Mental and Brain Health (formerly Africa Mental Health Research and Training Foundation), Nairobi, Kenya World Psychiatric Association Collaborating Centre for Research and Training, Nairobi, Kenya
Samuel Walusaka
Affiliation:
Africa Institute of Mental and Brain Health (formerly Africa Mental Health Research and Training Foundation), Nairobi, Kenya World Psychiatric Association Collaborating Centre for Research and Training, Nairobi, Kenya
Veronica Onyango
Affiliation:
Africa Institute of Mental and Brain Health (formerly Africa Mental Health Research and Training Foundation), Nairobi, Kenya World Psychiatric Association Collaborating Centre for Research and Training, Nairobi, Kenya
Kamaldeep Bhui
Affiliation:
Department of Psychiatry, Nuffield Department of Primary Care Health Sciences, Wadham College, University of Oxford, Oxford, UK World Psychiatric Association Collaborating Centre, Oxford, UK
Daniel Mamah
Affiliation:
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA
*
Corresponding author: David M. Ndetei; Email: dmndetei@amhf.or.ke
Rights & Permissions [Opens in a new window]

Abstract

Comprehending resilience in the face of mental health issues is important, especially for young people who deal with a variety of psychological pressures. This study aims to investigate the co-occurrence of several mental health conditions and the role of resilience as a potential intervention in youth 14–25 years in the Nairobi metropolitan area. We recruited 1,972 youths. The following self-administered instruments were used: resilience (ARM-R), hopelessness (BHS), depression (BDI, PHQ-9), PTSD (HTQ), loneliness (UCLA Loneliness Scale) and suicidality (C-SSRS). Descriptive statistics, Pearson correlation and hierarchical multiple regression analyses were conducted on the data. The key findings are that depression and hopelessness showed a strong negative association with resilience. PTSD and recent suicidal ideation and behavior showed less negative association with resilience. Building resilience is an important intervention for the conditions reported in our study among the youth. This study contributes novel insights into the intersection of multiple psychological stressors and resilience, paving the way for more targeted, integrative mental health interventions.

Topics structure

Information

Type
Research Article
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
Copyright
© The Author(s), 2025. Published by Cambridge University Press
Figure 0

Table 1. Variable scores and mean (SD; range)

Figure 1

Table 2. The associations between resilience, hopelessness, depression, loneliness, PTSD and suicidal ideation and behavior

Figure 2

Table 3. Simple linear regression analysis of resilience and hopelessness, depression, PTSD, loneliness (home and school) and suicidality (ideation and behavior)

Figure 3

Table 4. Hierarchical analysis of resilience and hopelessness, depression, PTSD, loneliness and suicidality (ideation and behavior)

Author comment: Resilience and its association with hopelessness, depression, loneliness, post-traumatic stress disorder (PTSD) and suicidal ideations and behavior in a cohort in the Nairobi Metropolitan — R0/PR1

Comments

David M. Ndetei,

Postal address: 48423-00100, Nairobi. Kenya

Email address: dmndetei@amhf.or.ke

The Editor,

Global Mental Health

2nd December 2024

Dear editor,

We are pleased to submit the manuscript entitled “The association between resilience, hopelessness, depression, loneliness, post-traumatic stress disorder (PTSD) and suicidal ideations and behaviour in a cohort in the Nairobi Metropolitan” for consideration in your journal.

This is an original manuscript and is not under consideration for publication elsewhere.

All authors affirm that they contributed sufficiently to project implementation, manuscript writing and share public responsibility of the manuscript. They participated in reviewing, approving and submission of the final article.

The authors have no competing interests with respect to the publication of this manuscript.

Thank you for your consideration.

Sincerely,

Prof. David M. Ndetei

Corresponding Author

Review: Resilience and its association with hopelessness, depression, loneliness, post-traumatic stress disorder (PTSD) and suicidal ideations and behavior in a cohort in the Nairobi Metropolitan — R0/PR2

Conflict of interest statement

Reviewer declares none.

Comments

This is an interesting study, on a large sample of youths in urban-semiurban settings in Kenya, focusing on the association among several psychosocial variables and the construct of resilience. It found several associations, with hopelessness and depression emerging as important ‘predictors’ of resilience on hierarchical regression analysis. The findings have some important implications for youth mental health at the level of public mental health, though that is beyond the scope of this study.

One important limitation of the manuscript is the complete lack of any mention of limitations! Certainly no study is entirely free of any limitation. Some of the relevant limitations that need to be acknowledged and addressed in the discussion section include (but are not limited to):

1. This is an ‘association’ study, which does not show causality in any direction. Although the regression analysis was conducted with resilience as the “dependent” variable, regression analysis is not really a prediction study. Replacing resilience with hopelessness as the “dependent” variable, for example, would have shown, perhaps equally strongly, that (lack of) resilience is a predictor of hopelessness, not the other way round.

2. In the same line, this was a cross-sectional study, with all the variables studied concomitantly. Almost all the variables studied are dynamic over time. It would have been important to conduct at least a two-point data collection to capture the dynamic process and relations among the study variables better, and could have come a step closer to using a predictive model.

3. It is not clear if all the study instruments were available in a valid shape for use as self-administered questionnaires in local language and was comprehensible by the study subjects. This is important because all the data are based on self report.

4. An adjusted R squared value of 0.246 in the final model of the regression, while not negligible in social sciences, is not a robust value either, indicating that there would be other important variables contributing to the resilience scores in the study sample.

5. The mean values of BDI and especially PHQ-9 fall in the range of mild depression. Given that this was a community sample and not a patient population (though not made very clear in the methodology), would the authors like to comment upon that?

6. In this regard, it would be important to know how such an impressively large sample was collected. What was the method? Was there any incentives for participation in the study? Was any attempt made at making the sample representative of the population or was it entirely a convenience sample? If so, all these must be addressed and mentioned as limitations.

Other than these, a few minor issues need addressing.

1. Page 5, General aim - “The study aims to examine the co-morbid of hopelessness, depression, suicidal ideations...” this sentence needs clarity and paraphrasing.

2. The title misses the focus of this paper on resilience, which becomes apparent from the aim statement onward. The authors may want to suitably moderate the title to reflect this focus.

3. The results show loneliness data as “At school” and “At home” whereas that is not mentioned while describing the scale under methodology.

4. Page 14, first paragraph: there are many double asterix signs, which probably indicates statistical significance but are confusing; these should be removed and P values mentioned instead.

5. Some of the references are incomplete and inaccessible; please rectify, e.g.,

Batsleer, J., Duggan, J., McNicol, S., Spray, S., & Angell, K. (2017). Loneliness Connects Us.42nd Street..

Centre, R. R. (2018). CYRM and ARM user manual. Resilience Research Centre.

Ipekci, B. (2021). Posttraumatic Stress and Resilience Among Iraqi and Syrian Refugees. University of Massachusetts Boston.

Labrague, L. J., JAAD, S., & Falguera, C. (2021). Social and emotional loneliness among college students during the COVID-19 pandemic..... (publication details missing)

Nowicki, A. (2008). Self-efficacy, sense of belonging and social support as predictors of

resilience in adolescents. (Publication details missing)

ODERA, O. W. (2022). ATTACHMENT STYLES AS PREDICTORS OF BEHAVIORS AMONG SECONDARY SCHOOL STUDENTS IN NAIROBI COUNTY, KENYA. (Publication details missing)

WHO. (2023). Suicide - key facts (publication and access details missing)

Review: Resilience and its association with hopelessness, depression, loneliness, post-traumatic stress disorder (PTSD) and suicidal ideations and behavior in a cohort in the Nairobi Metropolitan — R0/PR3

Conflict of interest statement

Reviewer declares none.

Comments

1. The abstract should have a clearer statement of the study’s novelty or unique contribution to the field.

2. The rationale for including participants aged 14–25 could be clarified. Why was this age range chosen, and does it align with resilience and mental health development studies?

3. The exclusion criteria (e.g., illiteracy and intoxication) need justification. How this might affect the generalizability of the findings?

4. The decision to use multiple tools for depression (BDI and PHQ-9) without explaining how discrepancies were handled could lead to confusion. There should be discussion arount this aspect.

5. The paper does not mention whether informed consent was obtained from participants

6. The paper does not discuss multicollinearity or other assumptions of regression analysis, which might impact the validity of the findings. For example, depression and hopelessness are likely correlated, which could affect the regression results. This should be addressed properly.

7. Tables in results section are not self-explanatory. For instance, the meaning of certain terms (e.g., “Adjusted R-Squared”) might not be clear to all readers without further elaboration.

8. The interpretation of correlation coefficients (e.g., “moderate negative associations”) should align with established thresholds (e.g., Cohen’s guidelines).

9. The discussion on the protective role of resilience needs more nuanced insights. For example, why is PTSD less impactful on resilience than expected, and how does this finding compare with other studies?

10. Discussion should also include on how the findings can translate into tangible mental health strategies or policies.

Recommendation: Resilience and its association with hopelessness, depression, loneliness, post-traumatic stress disorder (PTSD) and suicidal ideations and behavior in a cohort in the Nairobi Metropolitan — R0/PR4

Comments

Dear Author,

I hope this email finds you well.

Thank you for submitting your manuscript, “The association between resilience, hopelessness, depression, loneliness, post-traumatic stress disorder (PTSD) and suicidal ideations and behaviour in a cohort in the Nairobi Metropolitan”, to Cambridge Prisms: Global Mental Health. The reviewers have provided thoughtful and constructive feedback on your manuscript, and I believe their suggestions will be valuable in strengthening the overall quality and clarity of your work.

I would like to ask you to carefully review the comments provided by the reviewers and consider their suggestions in your revision. In particular, please ensure that you respond to each of the reviewers' points either by implementing their suggestions or providing a clear rationale for why you may choose not to incorporate certain recommendations.

Below, I’ve listed the specific comments from each reviewer for your reference:

Reviewer 1:

This is an interesting study, on a large sample of youths in urban-semiurban settings in Kenya, focusing on the association among several psychosocial variables and the construct of resilience. It found several associations, with hopelessness and depression emerging as important ‘predictors’ of resilience on hierarchical regression analysis. The findings have some important implications for youth mental health at the level of public mental health, though that is beyond the scope of this study.

One important limitation of the manuscript is the complete lack of any mention of limitations! Certainly no study is entirely free of any limitation. Some of the relevant limitations that need to be acknowledged and addressed in the discussion section include (but are not limited to):

1. This is an ‘association’ study, which does not show causality in any direction. Although the regression analysis was conducted with resilience as the “dependent” variable, regression analysis is not really a prediction study. Replacing resilience with hopelessness as the “dependent” variable, for example, would have shown, perhaps equally strongly, that (lack of) resilience is a predictor of hopelessness, not the other way round.

2. In the same line, this was a cross-sectional study, with all the variables studied concomitantly. Almost all the variables studied are dynamic over time. It would have been important to conduct at least a two-point data collection to capture the dynamic process and relations among the study variables better, and could have come a step closer to using a predictive model.

3. It is not clear if all the study instruments were available in a valid shape for use as self-administered questionnaires in local language and was comprehensible by the study subjects. This is important because all the data are based on self report.

4. An adjusted R squared value of 0.246 in the final model of the regression, while not negligible in social sciences, is not a robust value either, indicating that there would be other important variables contributing to the resilience scores in the study sample.

5. The mean values of BDI and especially PHQ-9 fall in the range of mild depression. Given that this was a community sample and not a patient population (though not made very clear in the methodology), would the authors like to comment upon that?

6. In this regard, it would be important to know how such an impressively large sample was collected. What was the method? Was there any incentives for participation in the study? Was any attempt made at making the sample representative of the population or was it entirely a convenience sample? If so, all these must be addressed and mentioned as limitations.

Other than these, a few minor issues need addressing.

1. Page 5, General aim - “The study aims to examine the co-morbid of hopelessness, depression, suicidal ideations...” this sentence needs clarity and paraphrasing.

2. The title misses the focus of this paper on resilience, which becomes apparent from the aim statement onward. The authors may want to suitably moderate the title to reflect this focus.

3. The results show loneliness data as “At school” and “At home” whereas that is not mentioned while describing the scale under methodology.

4. Page 14, first paragraph: there are many double asterix signs, which probably indicates statistical significance but are confusing; these should be removed and P values mentioned instead.

5. Some of the references are incomplete and inaccessible; please rectify, e.g.,

Batsleer, J., Duggan, J., McNicol, S., Spray, S., & Angell, K. (2017). Loneliness Connects Us.42nd Street..

Centre, R. R. (2018). CYRM and ARM user manual. Resilience Research Centre.

Ipekci, B. (2021). Posttraumatic Stress and Resilience Among Iraqi and Syrian Refugees. University of Massachusetts Boston.

Labrague, L. J., JAAD, S., & Falguera, C. (2021). Social and emotional loneliness among college students during the COVID-19 pandemic..... (publication details missing)

Nowicki, A. (2008). Self-efficacy, sense of belonging and social support as predictors of

resilience in adolescents. (Publication details missing)

ODERA, O. W. (2022). ATTACHMENT STYLES AS PREDICTORS OF BEHAVIORS AMONG SECONDARY SCHOOL STUDENTS IN NAIROBI COUNTY, KENYA. (Publication details missing)

WHO. (2023). Suicide - key facts (publication and access details missing)

Reviewer 2:

1. The abstract should have a clearer statement of the study’s novelty or unique contribution to the field.

2. The rationale for including participants aged 14–25 could be clarified. Why was this age range chosen, and does it align with resilience and mental health development studies?

3. The exclusion criteria (e.g., illiteracy and intoxication) need justification. How this might affect the generalizability of the findings?

4. The decision to use multiple tools for depression (BDI and PHQ-9) without explaining how discrepancies were handled could lead to confusion. There should be discussion arount this aspect.

5. The paper does not mention whether informed consent was obtained from participants

6. The paper does not discuss multicollinearity or other assumptions of regression analysis, which might impact the validity of the findings. For example, depression and hopelessness are likely correlated, which could affect the regression results. This should be addressed properly.

7. Tables in results section are not self-explanatory. For instance, the meaning of certain terms (e.g., “Adjusted R-Squared”) might not be clear to all readers without further elaboration.

8. The interpretation of correlation coefficients (e.g., “moderate negative associations”) should align with established thresholds (e.g., Cohen’s guidelines).

9. The discussion on the protective role of resilience needs more nuanced insights. For example, why is PTSD less impactful on resilience than expected, and how does this finding compare with other studies?

10. Discussion should also include on how the findings can translate into tangible mental health strategies or policies.

We look forward to receiving your revised manuscript and response to the reviewers’ feedback. If you have any questions or need further clarification, please don’t hesitate to reach out.

Best regards, Sara Romero

Decision: Resilience and its association with hopelessness, depression, loneliness, post-traumatic stress disorder (PTSD) and suicidal ideations and behavior in a cohort in the Nairobi Metropolitan — R0/PR5

Comments

No accompanying comment.

Author comment: Resilience and its association with hopelessness, depression, loneliness, post-traumatic stress disorder (PTSD) and suicidal ideations and behavior in a cohort in the Nairobi Metropolitan — R1/PR6

Comments

David M. Ndetei,

Postal address: 48423-00100, Nairobi. Kenya

Email address: dmndetei@amhf.or.ke

The Editor,

Cambridge Prisms: Global Mental Health

21st February 2025

Dear editor,

We are pleased to resubmit our revised manuscript entitled “Resilience and its Association with Hopelessness, Depression, Loneliness, Post-traumatic Stress Disorder (PTSD), and Suicidal Ideations and Behaviour in a Cohort in the Nairobi Metropolitan” for further consideration in Cambridge Prisms: Global Mental Health.

We appreciate the constructive feedback from the reviewers, which has greatly helped us improve the quality of our manuscript. We have carefully considered and addressed all the reviewer comments in our revision. A detailed response to each comment has been provided in the accompanying response section. Additionally, we have submitted both a clean version and a tracked-changes version of the revised manuscript for ease of review.

We confirm that this manuscript is original and is not under consideration for publication elsewhere. All authors have contributed significantly to the research and manuscript preparation and have approved the final version for submission. We declare that there are no competing interests related to this work.

Thank you for your consideration.

Sincerely,

Prof. David M. Ndetei

Corresponding Author

Review: Resilience and its association with hopelessness, depression, loneliness, post-traumatic stress disorder (PTSD) and suicidal ideations and behavior in a cohort in the Nairobi Metropolitan — R1/PR7

Conflict of interest statement

none declared

Comments

All the reviewer comments have been adequately addressed in the revised version.

Recommendation: Resilience and its association with hopelessness, depression, loneliness, post-traumatic stress disorder (PTSD) and suicidal ideations and behavior in a cohort in the Nairobi Metropolitan — R1/PR8

Comments

No accompanying comment.

Decision: Resilience and its association with hopelessness, depression, loneliness, post-traumatic stress disorder (PTSD) and suicidal ideations and behavior in a cohort in the Nairobi Metropolitan — R1/PR9

Comments

No accompanying comment.