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An individualised treatment algorithm for tumour stage 1 glottic squamous cell carcinoma

Published online by Cambridge University Press:  17 October 2013

U Aydil ,
M Akmansu ,
Y Kizil ,
Ö Yazici ,
S Üstün ,
F Karaloğlu  and
A Köybaşioğlu
U Aydil*
Affiliation:
Department of Otorhinolaryngology, Gazi University School of Medicine, Ankara, Turkey
M Akmansu
Affiliation:
Department of Radiation Oncology, Gazi University School of Medicine, Ankara, Turkey
Y Kizil
Affiliation:
Department of Otorhinolaryngology, Gazi University School of Medicine, Ankara, Turkey
Ö Yazici
Affiliation:
Department of Radiation Oncology, Gazi University School of Medicine, Ankara, Turkey
S Üstün
Affiliation:
Department of Otorhinolaryngology, Gazi University School of Medicine, Ankara, Turkey
F Karaloğlu
Affiliation:
Department of Otorhinolaryngology, Gazi University School of Medicine, Ankara, Turkey
A Köybaşioğlu
Affiliation:
Department of Otorhinolaryngology, Gazi University School of Medicine, Ankara, Turkey
*
Address for correspondence: Dr Utku Aydil, Gazi Ün Tıp Fak KBB AD, 06500 Beşevler, Ankara, Turkey Fax: +90 312 202 4357 E-mail: utkuaydil@yahoo.com
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Abstract

Objective:

To report and discuss the outcome of a treatment algorithm for patients with tumour stage 1 glottic squamous cell carcinoma.

Method:

A retrospective outcome analysis study was performed using data from a tertiary referral centre.

Results:

Sixty-nine patients were treated with radiotherapy and 26 with surgery, in accordance with the treatment algorithm. Five-year overall survival rates were the same for both treatment groups (92 per cent). Five-year disease-specific survival rates were 100 per cent for surgery, 98 per cent for radiotherapy and 99 per cent overall. The overall 5-year laryngeal preservation rate was 89.1 per cent, being 95.7 per cent for surgery patients and 86.7 per cent for radiotherapy patients (p = 0.502). There was no significant association between laryngeal preservation rates and age (p = 0.779), anterior commissure involvement (p = 0.081), tumour stage (1a or 1b) (p = 0.266) or treatment modality (surgery or radiotherapy; p = 0.220). There was no significant difference in local recurrence rates between the two treatment groups (19.3 per cent for radiotherapy vs 10.0 per cent for surgery; p = 0.220). The overall 5-year regional recurrence rate was 1.2 per cent.

Conclusion:

Tumour stage 1 glottic carcinoma can be managed with different treatment modalities, following an individualised treatment algorithm, with results comparable to published outcomes.

Keywords

Laryngeal CancerGlottisRadiotherapyLaser TherapyLaryngectomy

Information

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 127 , Issue 11 , November 2013 , pp. 1127 - 1133
Copyright
Copyright © JLO (1984) Limited 2013 

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