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Expression of CD44 variant isoforms, CD44v3 and CD44v6, are associated with prognosis in nasopharyngeal carcinoma

Published online by Cambridge University Press:  25 July 2016

K Sagawa ,
N Uwa ,
T Daimon ,
M Sakagami  and
T Tsujimura
K Sagawa
Affiliation:
Department of Otorhinolaryngology – Head and Neck Surgery, Hyogo College of Medicine, Nishinomiya, Japan
N Uwa*
Affiliation:
Department of Otorhinolaryngology – Head and Neck Surgery, Hyogo College of Medicine, Nishinomiya, Japan
T Daimon
Affiliation:
Department of Biostatistics, Hyogo College of Medicine, Nishinomiya, Japan
M Sakagami
Affiliation:
Department of Otorhinolaryngology – Head and Neck Surgery, Hyogo College of Medicine, Nishinomiya, Japan
T Tsujimura
Affiliation:
Department of Pathology, Hyogo College of Medicine, Nishinomiya, Japan
*
Address for correspondence: Dr Nobuhiro Uwa, Department of Otorhinolaryngology – Head and Neck Surgery, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan Fax: +81 798 41 8976 E-mail: nobu-uwa@hyo-med.ac.jp
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Abstract

Objective:

The clinical and prognostic significance of CD44 variant isoform expression in nasopharyngeal carcinoma is not well known. This study aimed to clarify whether CD44 variant isoform expression serves as a prognostic factor in nasopharyngeal carcinoma.

Methods:

Forty-two nasopharyngeal carcinoma patients, who underwent concurrent chemoradiotherapy as the initial treatment, were the subjects of investigation. Expression of CD44 variant isoforms, CD44v3, CD44v4, CD44v5, CD44v6 and CD44v7, in nasopharyngeal carcinoma was assessed in relation to concurrent chemoradiotherapy resistance and disease-specific survival of the patients.

Results and conclusion:

The patients with CD44v6 high expression showed a clinically incomplete response to concurrent chemoradiotherapy at the primary site. The disease-specific survival rate was lower in patients with high expression of CD44v3 than in those with low expression. These results suggest that analysis of CD44v6 and CD44v3 expression is useful in estimating prognosis and determining effective treatment strategies in nasopharyngeal carcinoma.

Keywords

CD44 AntigensNasopharyngeal CarcinomaImmunohistochemistrySurvival RateChemoradiotherapy
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 130 , Issue 9 , September 2016 , pp. 843 - 849
Copyright
Copyright © JLO (1984) Limited 2016 

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Footnotes

Presented at the 117th Annual Meeting of the American Academy of Otolaryngology –Head and Neck Surgery, 29 September – 2 October 2013, Vancouver, Canada.

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