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Comparative efficacies of topical antiseptic eardrops against biofilms from methicillin-resistant Staphylococcus aureus and quinolone-resistant Pseudomonas aeruginosa

Published online by Cambridge University Press:  18 June 2018

C K Youn ,
Y Jun ,
E-R Jo ,
S-J Jang ,
H Song  and
S I Cho
C K Youn
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Chosun University School of Medicine, Gwangju, South Korea Department of Premedical Science, Chosun University School of Medicine, Gwangju, South Korea
Y Jun
Affiliation:
Department of Anatomy, Chosun University School of Medicine, Gwangju, South Korea
E-R Jo
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Chosun University School of Medicine, Gwangju, South Korea
S-J Jang
Affiliation:
Department of Laboratory Medicine, Chosun University School of Medicine, Gwangju, South Korea
H Song
Affiliation:
Department of Occupational and Environmental Medicine, Chosun University School of Medicine, Gwangju, South Korea
S I Cho*
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Chosun University School of Medicine, Gwangju, South Korea
*
Author for correspondence: Dr Sung Il Cho, Department of Otolaryngology – Head and Neck Surgery, Chosun University, 365 Pilmun-daero, Dong-gu, Gwangju 61453, South Korea Fax: +82 62 225 2702 E-mail: chosi@chosun.ac.kr
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Abstract

Objective

The present study aimed to compare the anti-biofilm activities of four commonly available antiseptic eardrops against biofilms from methicillin-resistant Staphylococcus aureus and quinolone-resistant Pseudomonas aeruginosa in vitro.

Methods

The anti-biofilm activities of 50 per cent Burow's solution, vinegar with water (1:1), 2 per cent acetic acid solution, and 4 per cent boric acid solution were evaluated using biofilm assays. Additionally, the anti-biofilm activities of the four antiseptic solutions against tympanostomy tube biofilms were compared using a scanning electron microscope.

Results

The inhibition of biofilm formation from methicillin-resistant S aureus and quinolone-resistant P aeruginosa occurred after treatment with 4 per cent boric acid solution, 2 per cent acetic acid solution, and vinegar with water (1:1). However, 50 per cent Burow's solution did not exhibit effective anti-biofilm activity.

Conclusion

The results indicate that 4 per cent boric acid solution and vinegar with water (1:1) are potent inhibitors of biofilms from methicillin-resistant S aureus and quinolone-resistant P aeruginosa, and provide safe pH levels for avoiding ototoxicity.

Keywords

Anti-Infective AgentsMethicillin-Resistant Staphylococcus AureusQuinolonesPseudomonas AeruginosaBiofilmsOtitis Media

Information

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 132 , Issue 6 , June 2018 , pp. 519 - 522
Copyright
Copyright © JLO (1984) Limited, 2018 

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Footnotes

Dr S I Cho takes responsibility for the integrity of the content of the paper

References

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