Vaccine disparities and preventative healthcare are critical in public health efforts and support individual and community health [Reference Syed, Kapera and Chandrasekhar1]. Every year in the USA, many people suffer from diseases that vaccines can prevent. Consequently, prioritizing the prevention of infectious diseases by increasing vaccination rates remains a public health priority. Despite this importance, there has been a notable decline in routine vaccinations, primarily driven by vaccine hesitancy [Reference Syed, Kapera and Chandrasekhar1].
Individual, social, economic, and environmental factors create challenges to vaccination access and uptake, often affecting racial and ethnic minorities and those living in communities that are economically underserved [2]. For instance, limited healthcare access, a lack of transportation, and medical mistrust have been found to contribute to vaccine disparities and hesitancy [Reference Abrams and Szefler3]. Thus, ensuring vaccine equity, access, and uptake for groups experiencing disparities in immunization requires addressing these inequities, social determinants of health (SDoH), and vaccine hesitancy [Reference Peña, Schwartz, Hernandez-Vallant and Sanchez4]. Global pandemics further expose these inequities [Reference Peña, Schwartz, Hernandez-Vallant and Sanchez4], compelling communities and the healthcare field to innovate sustainable solutions [Reference Syed, Kapera and Chandrasekhar1]. Individuals in the USA with lower incomes are less likely to receive the Influenza vaccine [Reference Gaskin, Woods and Ghosh5], while mistrust of the medical community among African Americans/Black contributed to the low uptake and demand for the H1N1 vaccine (swine flu) [Reference Burger, Reither, Mamelund and Lim6].
Research demonstrates the role of trust and community collaboration in addressing vaccination disparities and hesitancy [Reference Plough, Bristow, Fielding, Caldwell and Khan7]. Community-engaged strategies are pivotal to understanding and better meeting community vaccination needs to improve uptake and address hesitancy [2]. These strategies draw on trusted community-based organizations (CBOs) and community members’ experiences to meet vaccination needs effectively [Reference Syed, Kapera and Chandrasekhar1]. Thus, a university-public health partnership aligning with the T4 translational research stage [8] can improve health equity and mitigate vaccination disparities. Adding pharmacy personnel to these partnerships, leveraging their knowledge and expertise, can reduce disparities in the uptake of immunization services in community pharmacy settings [Reference Pattin9].
Public health partners, including community pharmacies and community-based organizations (CBOs), have been pivotal in vaccine rollout. Community pharmacies offer convenient, high-quality, cost-effective healthcare services[Reference Hohmeier and Desselle10], contributing to administering over 305.5 million COVID-19 vaccine doses and addressing uptake and hesitancy [Reference Virginia11,Reference Ecarnot, Crepaldi and Juvin12]. Incorporating a trusted CBO partner improves access to systemically marginalized populations experiencing SDoH challenges and promotes community trust [Reference Baciu, Negussie and Geller13]. Leveraging academic health centers alongside CBOs has been found to address health disparities in rural communities successfully [Reference Barrett, Ingraham and Bethea14]. Despite these advancements, efforts have not incorporated a community pharmacy partner. Collectively, this evidence supports the development of a university-public health partnership to include community pharmacies to improve health care for people who are medically underserved [Reference Barrett, Ingraham and Bethea14].
The objective of this study was to describe and evaluate a university-public health use case that employed practical SDoH-based strategies to address vaccination disparities from June 2021 to October 2023. The evaluation utilized translational science benefits concepts to collate the use case processes and outcomes, positioning the findings as a transformative example of practical best practices for implementing SDoH-based strategies to improve health.
Methods and materials
Conceptual framework
As recommended for clinical and translational research, we adapted the Translational Science Benefits Logic Model (TSBM) [Reference Luke, Sarli and Suiter15] to describe the university-public health partnership and subsequent evaluation. The TSBM illustrates how the partnership resources (e.g., finances, knowledge) guide and facilitate scientific activities (e.g., collaborations, conducting research) associated with the partnership. These activities link to scientific output, outcomes, and health and societal benefits, serving as criteria for assessing the impact of the partnership (Fig. 1).
Translational science benefits logic model adapted for public health (T4) research. CBO = community based organization; SDoH = social determinants of health.
Use case partnership overview
In 2021, the Purdue University Center for Health Equity and Innovation (CHEqI) partnered with Gleaners Food Bank of Indiana and Walgreens to offer no-cost preventative vaccines (Influenza and COVID-19) at food bank distribution centers and mobile pantry sites. CHEqI, the university partner, is one of Purdue’s first health equity coordinating centers [Reference Gonzalvo, Meredith and Adeoye-Olatunde16]. Initially, the partnership focused on Gleaners Food Bank, a major Midwest food bank with a shared interest in improving vaccine access. Walgreens, the community pharmacy partner, facilitated vaccine procurement. By late 2021, the partnership expanded to include St Vincent de Paul Food Pantry and Wheeler Mission, which provides services to individuals experiencing homelessness. These collaborations extended to other organizations, including community cultural centers, churches, and youth camps.
Partnership and alignment to conceptual framework
The subsections describe a use case application of a university-CBO partnership guided by the adapted TSBM model (Fig. 1). The TSBM provides and guides scalable strategies for university-community partnerships across five primary domains: resources, public health scientific activities, outputs, and outcomes, as well as the ensuing health and social benefits. Through our use case example, we provide essential components and details for establishing university-CBO partnerships, offering insights into establishing and co-locating preventive and vaccination health services.
Partnership resources
The partnership secured financial resources through seed funding from the Marion County Public Health Department and funds from the National Association of Chain Drug Stores. Grant resources supported pharmacy fellows, interpreters, incentives for student volunteers, advertising, and supplies. Infrastructure resources included event spaces, vaccine procurement, and organizational leadership, with the university partner overseeing logistics. Human resources involved diverse university faculty, research staff, students, and community partners. Knowledge resources leveraged multidisciplinary and methodological expertise from public health and pharmacy professionals to implement and translate science through vaccine events, evaluation, and dissemination.
Public health scientific activities
Strategic funding and dynamic collaborations sustained the partnership. State Department Health funding supported ongoing activities, growth, and impact. The partnership harnessed collective strengths to address vaccination disparities and maximized expertise, resources, and communities to address complex vaccination-related challenges and barriers.
Regarding responsible conduct of research, this study received exempt approval from the Institutional Review Board and ensured ethical research practices. The university partner conducted public health (T4) research, collecting vaccine interest and outcome data. The partnership recognized the value of validated instruments in assessing vaccine interest and hesitancy, yet it was not the primary focus of these interactions. We deemed administering lengthy questionnaires that could disrupt the CBOs infeasible and impractical.
Trained event volunteers conducted guided conversations with CBO clientele to collect vaccine interest data. Volunteers have public health and pharmacy backgrounds, exposing them to special populations and minority groups. We trained volunteers by providing examples of common vaccine hesitancy reasons and effective talking points. Student volunteers with Spanish language skills connected effectively with the local Hispanic/Latino community. Volunteers had conversations to (1) determine the need for vaccination, (2) assess vaccination interest, and (3) address vaccine hesitancy through person-centered discussion. Volunteers asked clients about their vaccination interest and booster status, recorded responses on a questionnaire, and returned to a university point-person. Volunteers assessed vaccine hesitancy subjectively based on clients’ responses during the questionnaire administration. Volunteers addressed vaccine hesitancy by providing vaccination data, tailoring conversations to address specific concerns, and building trust with clientele through consistent presence and a diverse staff. We collected hesitancy data when sufficient volunteers were available (n = 44 events).
University staff collected additional information on individuals who received vacations to gather vaccine outcome data, including age, ethnicity, race, gender, and which vaccine(s) the client received via the Vaccine Administration Record. University staff collected event-level data, including the number of staff, volunteers, and interpreters present, along with the total number of clients who passed through the food bank/food pantry, and which vaccines were offered at the event.
We used IBM SPSS Statistics (Version 29) to compute descriptive statistics, characterizing program events and outcomes.
Public health scientific outputs and outcomes
By leveraging existing and expanded scholarship stemming from this partnership, collaborators foresee its potential for replication across other Universities and CBOs, catalyzing future SDoH strategies and public health initiatives.
Health and Societal Benefits
The partnership’s clinical and medical benefits include the number of vaccines administered and the clients’ demographic information. The partnership subsequently increased vaccine knowledge and decreased vaccine hesitancy by administering vaccines to CBO clientele. The intermediate partnership outcome is the sustainable, mutually beneficial collaboration between a university, community pharmacy, and CBOs as activities evolve and expand.
Results
Table 1 includes findings of the public health partnership aligned with TSBM domains. One hundred seven vaccination events occurred from June 3, 2021, to October 27, 2023, with 91.6% occurring at food banks/pantries and homeless shelters. Most events occurred at indoor locations, and approximately 16.8% occurred at mobile food pantry events. Food pantries/banks served an average of 577 families per event over two to four hours.
University-public health partnership vaccination event input characteristics, activities, outputs, and outcomes as defined by the logic model [Reference Luke, Sarli and Suiter15]
a Age impacted by age-specific dosing recommendations for COVID-19 and influenza vaccines.
Events occurred within under-resourced areas in Indianapolis. Most vaccinated individuals self-identified as Black or African American (31.4%) or White (33.2%). Additionally, 46.1% of vaccinated individuals self-identified as Latino ethnicity and frequently necessitated interpreters who spoke Spanish for communication. While approximately 65% of events required interpreters, only 16% hired professional interpreters, and the remaining events had sufficient volunteers and staff serving as interpreters.
The majority of vaccination events provided two different preventative vaccines (63.6%). A total of 3,021 vaccines were given across all events, with a mean of 28 vaccines given per two- to four-hour event. One noteworthy food pantry event successfully administered 133 preventative vaccines. Volunteers assessed vaccine interest at 53% of events, with a mean of 127 people assessed per event. CBO clientele were also screened for vaccine hesitancy at 50% of events, with volunteers reporting that 1,225 individuals were vaccine-hesitant.
Discussion
During the pandemic, affordability, poor healthcare experiences, language barriers, and transportation issues worsened healthcare access [Reference Abrams and Szefler3]. Aligned with the T3 and T4 translational pipeline, initiatives addressing these challenges across academic and community sectors offered the potential for greater impacts on individual and community health [17]. This public health partnership focused on addressing vaccination access disparities among racial/ethnic minorities and marginalized populations by co-locating vaccination services with SDoH services to ensure convenient access. In partnering with CBOs providing services to food and/or housing-insecure populations, the partnership utilized person-centered conversations to address vaccine hesitancy. Effective communication, providing clear and accurate information on vaccine safety and benefits, has been found to mitigate vaccine hesitancy and improve vaccine confidence [Reference MacDonald18].
The university and Walgreens staff’s consistent presence at CBO sites contributed to addressing vaccine hesitancy and increasing uptake. Over time, as clients receive new information, their views of vaccination may change. This approach aligns with patient reminder interventions and evidence-based strategies that have shown success in increasing immunization uptake and reducing hesitancy [Reference Vann Jacobson, Jacobson, Coyne-Beasley, Asafu-Adjei and Szilagyi19].
While barriers to vaccination persist, there is a decline in pandemic response funding, demonstrating a need for an efficient and cost-effective model for providing vaccinations. This model effectively co-locates vaccinations with other services, serving as a vaccination and population health strategy that complements prevention efforts such as point-of-care testing and health screenings.
This public health partnership model has expanded to provide additional health services, including naloxone distribution, blood pressure screenings, and tobacco cessation education. These efforts have shown early promise in initial data. University-CBO partnerships bringing vaccinations and other preventive health services to communities that are under-resourced effectively reduce access barriers and address health disparities. Providing interpreters, as recommended by the CDC [20]. enhances health literacy for diverse populations.
This partnership model, successful in urban settings, has begun pilot vaccination events in rural areas. Initial findings indicate the need to tailor the model to be relevant to rural communities, including understanding cultural norms and building trust, particularly within faith-based communities like the Amish.
Limitations
This evaluation focused on enhancing vaccine uptake and addressing vaccine hesitancy among individuals experiencing food insecurity and homelessness while minimizing disruptions to food distribution and shelter operations. However, the study has limitations. The University partner tailored data collection strategies to prevent disruptions, limiting the use of more sophisticated evaluation methods and validated instruments for assessing vaccine hesitancy. Due to privacy concerns, events did not collect patient-identifiable data, impeding the tracking of repeat vaccinations at events. These limitations highlight the need for future research to collect more comprehensive data while considering operational demands when engaging with CBOs.
Conclusion
The public health partnership demonstrated success in efficiently administering preventative vaccines, making it a model applicable to numerous health disparities prevalent in communities that are under-resourced. Future research can evaluate the longer-term impact on health and healthcare optimization while also investigating the experiences of key collaborators (e.g., university personnel, students, community partners, and community pharmacies) that are integral to fostering and sustaining the partnership.
Acknowledgements
A special thanks to Gleaners Food Bank of Indiana, Wheeler Mission Shelter for Men, Wheeler Mission Center for Women & Children, St Vincent DePaul Food Pantry, Walgreens, and Indiana Pharmacy Association. Collectively, the investigators thank all community-based organization partners and the communities they serve, pharmacy partners, and university student volunteers for their engagement in these vaccination events.
Author contributions
Susie Crow, PharmD, MPH: Conceptualization, data curation, formal analysis, project administration, investigation, writing – original manuscript draft, writing – review & editing. Carlyn Kimiecik, MSW: Investigation, methodology, visualization, writing – original draft, writing – review & editing. Omolola A. Adeoye-Olatunde, PharmD, MS: Conceptualization, formal analysis, funding acquisition, investigation, methodology, supervision, verification, writing – review & editing. Megan Conklin, PharmD, MPH: Data curation, formal analysis, project administration, investigation, verification, writing – original manuscript draft, writing – review & editing. Jordan Smith, PharmD, AAHIVP: Resources, project administration, writing – review & editing. Sonak D. Pastakia, PharmD, MPH, PhD: Conceptualization, funding acquisition, supervision, writing – review & editing. Alicia Dinkeldein: Resources, project administration, writing – review & editing. Peter Zubler: Resources, project administration, writing – review & editing. Jasmine D. Gonzalvo, PharmD: Conceptualization, funding acquisition, supervision, writing – review & editing.
Funding statement
This work was supported by the Marion County Public Health Department, City of Indianapolis, and Resolve to Save Lives COVID-19 Community Recovery Grant [21101970] and the National Association of Chain Drug Stores Foundation Innovation Award.
Competing interests
None.
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