Hostname: page-component-6766d58669-bkrcr Total loading time: 0 Render date: 2026-05-17T04:56:30.466Z Has data issue: false hasContentIssue false
  • English
  • Français

Local immune status and tumour marker expression in the human larynx

Published online by Cambridge University Press:  22 May 2009

T Nakashima ,
H Tomita ,
S Chitose ,
H Umeno  and
K Sato
T Nakashima*
Affiliation:
Department of Otolaryngology - Head and Neck Surgery, Kurume University School of Medicine, Kurume, Japan
H Tomita
Affiliation:
Department of Otolaryngology - Head and Neck Surgery, Kurume University School of Medicine, Kurume, Japan
S Chitose
Affiliation:
Department of Otolaryngology - Head and Neck Surgery, Kurume University School of Medicine, Kurume, Japan
H Umeno
Affiliation:
Department of Otolaryngology - Head and Neck Surgery, Kurume University School of Medicine, Kurume, Japan
K Sato
Affiliation:
Department of Otolaryngology - Head and Neck Surgery, Kurume University School of Medicine, Kurume, Japan
*
Address for correspondence: Dr Tadashi Nakashima, Department of Otolaryngology Head and Neck Surgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan. Fax: +81 942 37 1200 E-mail: orlkaku@med.kurume-u.ac.jp
Get access Rights & Permissions [Opens in a new window]

Abstract

This study examined the local immune status and tumour marker expression in secretions and related tissue specimens from the laryngeal ventricle, comparing individuals with and without head and neck cancer. Laryngeal secretion and mucosal tissue specimens were collected during laryngeal microsurgery or surgical laryngectomy. The laryngeal secretions were found to contain immunological factors such as immunoglobulins G and A and secretory immunoglobulin A. A high level of the tumour marker Cyfra 21-1 was also detected in laryngeal secretions and mucosal tissue. Lows levels of secretory immunoglobulin A and Cyfra 21-1 were seen in the laryngeal mucosal tissue of controls and patients who had previously undergone radiation therapy. The level of secretory immunoglobulin A in laryngeal secretions closely correlated to the level of this immunoglobulin in mucosal tissue. These results indicate that local immunity is present in the human larynx; furthermore, it is strongly affected both by the presence of malignancy and by laryngeal cancer treatments such as irradiation.

Keywords

Laryngeal SecretionLocal Immune StatusSecretory IgACyfra 21-1

Information

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 123 , Supplement S31 , May 2009 , pp. 1 - 4
Copyright
Copyright © JLO (1984) Limited 2009

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

1Tomasi, TB Jr, Jan, EM, Solomon, A, Prendergast, RA. Characteristics of an immune system common to certain external secretions. J Exp Med 1965;121:101–24CrossRefGoogle ScholarPubMed
2Brandtzaeg, P. Mucosal and glandular distribution of immunoglobulin components. Differential localization of free and bound SC in secretory epithelial cells. J Immunol 1974;112:1553–9CrossRefGoogle ScholarPubMed
3Nakashima, T, Makishima, K, Komiyama, S, Takeda, K, Hiroto, I. Local immune system in the developing fetal larynx. Laryngoscope 1980;91:398–407CrossRefGoogle Scholar
4Yonekawa, S, Fukunaga, H, Umeno, H, Mori, K, Nakashima, T. Subglottic airway becomes stable with age in the human infant larynx. Acta Otolaryngol (Stockh) 2000;120:444–9Google ScholarPubMed
5Nakashima, T, Komiyama, S, Makishima, K, Takeda, K, Hiroto, I. Immunopathological study of the larynx. IgA distribution and secretory activity. Ann Otol Rhinol Laryngol 1980;89:359–65CrossRefGoogle ScholarPubMed
6Mogi, G, Watanabe, N, Maeda, S, Umehara, T. Laryngeal secretions. An immunological and immunohistological study. Acta Otolaryngol (Stockh) 1979;87:129–41CrossRefGoogle Scholar
7Tanaka, M, Nakashima, T, Uemura, T. A survey of the pattern of glandular distribution in the larynges of human infants. Eur Arch Otorhinolaryngol 1994;251 (suppl 1):80–6CrossRefGoogle ScholarPubMed
8Sato, K, Hirano, M. Age-related changes in the human laryngeal glands. Ann Otol Rhinol Laryngol 1998;107:525–9CrossRefGoogle ScholarPubMed
9Ceruse, P, Rabilloud, M, Charrie, A, Dubreuil, C, Disant, F. Study of Cyfra 21-1, a tumor marker, in head and neck squamous cell carcinoma. Ann Otol Rhinol Laryngol 2005;114:768–76CrossRefGoogle ScholarPubMed
10Doweck, I, Barak, M, Greenberg, E, Uri, N, Kellner, J, Lurie, M et al. Cyfra 21-1. A new potential tumor marker for squamous cell carcinoma of head and neck. Arch Otolaryngol Head Neck Surg 1995;121:177–81CrossRefGoogle ScholarPubMed
11Nakashima, T, Tomita, H, Tsuda, S, Chitose, S. Radiotherapy of the neck influences the distribution of laryngeal secretory glands. J Laryngol Otol 2005;119:976–80CrossRefGoogle ScholarPubMed