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Non-Hodgkin's extranodal lymphoma: a clinico-pathological study of 24 cases involving head and neck sites

Published online by Cambridge University Press:  29 June 2007

Colin Wallace ,
Alan D. Ramsay  and
Robert E. Quiney
Colin Wallace
Affiliation:
Head and Neck Oncology Group, University College Hospital, London.
Alan D. Ramsay
Affiliation:
Department of Histopathology. School of Medicine, University College, London.
Robert E. Quiney*
Affiliation:
Head and Neck Oncology Group, University College Hospital, London.
*
Senior Registrar, Royal National Throat, Nose and Ear Hospital, Gray's Inn Road, London WC1X 8DA.
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Abstract

A series of of 24 patients wtih a documented diagnosis of non-Hodgkin's extranodal lymphoma (ENL) involving head and neck sites (excluding the cranial cavity) has been studied. In view of recent advances in the diagnosis of lymphoma, a retrospective histopathological review has been undertaken to place all patients in standardized classifications for morphology (the working formulation) and immunology (Kiel). This resulted in a change of diagnosis from non-Hodgkin's lymphoma in four. The histopathology of these four cases, and the implication of such changed diagnoses are discussed. Of the 20 patients confirmed as having non-Hodgkin's ENL, 16 had primary ENL and four had an ENL focus secondary to disease elsewhere. Three patients in this series had an initial diagnosis made of another malignancy, but histopathological review prior to treatment changed the diagnosis to ENL. Details of presentation, pretreatment evaluation, immunohistochemistry, treatment and course have been analysed. The principal treatment policy for primary ENL has been radiotherapy. Of the 12 patients who received this treatment ten achieved a complete response (83 per cent). Eight remain free of disease at the time of writing. The role of adjuvant chemotherapy is also considered.

Information

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 102 , Issue 10 , October 1988 , pp. 914 - 922
Copyright
Copyright © JLO (1984) Limited 1988

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References

American Joint Committee (1983) Manual for Staging of Cancer, pp. 31–6 Lippincott, Philadelphia.Google Scholar
Banfi, A., Bonnadonna, G., Ricci, S. B., Milani, F., Molinari, R., Monfardini, S. and Zucali, R. (1972) Malignant lymphomas of Waldeyer's ring. British Medical Journal, 3: 140–3.CrossRefGoogle ScholarPubMed
Bennett, M. H., Farrer-Brown, G., Henry, K. and Jelliffe, A. M. (1974) Classification of non-Hodgkin's lymphoma. Lancet, 2: 405–406.CrossRefGoogle Scholar
Billie, J. D., Wetzel, W. J. and Suen, J. Y. (1982) Thyroid lym-phoma with adjacent nerve paralysis. Archives of Otolaryngol-ogy, 108: 517–519.CrossRefGoogle Scholar
Burke, J. S., Butler, J. J. and Fuller, L. M. (1977) Malignant lymphomas of the thyroid: a clinical pathological study of 35 patients. Cancer, 39: 1587–1602.3.0.CO;2-V>CrossRefGoogle ScholarPubMed
Carbone, P. P., Kaplan, H. S., Musshoff, K., Smithers, D. W. and Tubiana, M. (1971) Report on the Committee on Hodgkin's disease staging classification. Cancer Research, 31: 1860–1861.Google Scholar
Ersboll, J., Schultz, H. B., Hougaard, P., Nissen, N. I. and Hou-Jensen, K. (1985) Comparison of the working formulation of non-Hodgkin's lymphoma with the Rappaport, Kiel and Lukes and Collins classifications. Cancer, 55: 2442–2458.3.0.CO;2-9>CrossRefGoogle ScholarPubMed
Freeman, C., Berg, J. W. and Cutler, S. J. (1972) Occurrence and prognosis of extranodal lymphomas. Cancer, 29: 252–260.3.0.CO;2-#>CrossRefGoogle ScholarPubMed
Hoppe, R. T. (1985) The role of radiation therapy in the management of non-Hodgkin's lymphomas. Cancer, 55: 2176–2183.3.0.CO;2-L>CrossRefGoogle ScholarPubMed
Isaacson, P., Jones, D. B., Sworn, M. J. and Wright, D. H. (1982) Malignant histiocytosis of the intestine: report of three cases with immunological cytochemical analysis. Journal of Clinical Pathology, 35: 510–516.CrossRefGoogle ScholarPubMed
Isaacson, P. and Wright, D. (1985) Extranodal malignant lym-phoma arising from mucosa-associated lyphoid tissue. Cancer, 53: 2515–2524.3.0.CO;2-C>CrossRefGoogle Scholar
Isaacson, P. G., Spencer, J., Connolly, C. E., Pollock, D. J., Stein, H., O'Connor, N. T. J., Bevan, D. H., Kirkham, N., Wainscoat, J. S. and Mason, D. Y. (1985) Malignant histiocytosis of the intestine: a T-cell lymphoma. Lancet, 2: 688–691.CrossRefGoogle ScholarPubMed
Kadin, M. E., Berard, C. W., Nauba, K. and Wakasa, H. (1983) Lymphoproliferative diseases in Japan and western countries. Human Pathology, 14: 745–772.CrossRefGoogle ScholarPubMed
Kahn, H. J., Marks, A., Thorn, H. and Baumal, R. (1981) Role of antibody to S100 protein in diagnostic pathology. American Journal of Clinical Pathology, 79: 341–347.CrossRefGoogle Scholar
Knowles, D. M., Jacobiec, F. A. (1982) Ocular adnexial lymphoid neoplasms. Human Pathology, 13: 148–162.CrossRefGoogle Scholar
Lazzarino, M., Morra, E., Rossa, R., Brusamolino, E., Pagnucco, G., Castello, A., Ghisolfi, A., Tan, A., Zannaro, G. and Ber-nasconi, C. (1985) Clinicopathologic and immunologic characteristics of non-Hodgkin's lymphomas presenting in the orbit. Cancer, 55: 1907–1012.3.0.CO;2-J>CrossRefGoogle ScholarPubMed
Lennert, K., Mohri, N., Stein, H. and Kaiserling, E. (1975) The histopathology of malignant lymphoma. British Journal of Haematology, 31: 193–205 (suppl).CrossRefGoogle Scholar
Lennert, K. (1978) Malignant Lymphomas other than Hodgkin's Disease. Springer Verlag, New York.CrossRefGoogle Scholar
Lukes, R. J. and Collins, R. D. (1974) Immunologic characterization of human malignant lymphomas. Cancer, 34: 1488–1503.3.0.CO;2-C>CrossRefGoogle ScholarPubMed
Mill, W. B., Lee, F. A. and Fransilla, K. O. (1980) Radiation therapy treatment of stage I and II extranodal non-Hodgkin's lymphoma of the head and neck. Cancer, 45: 653–661.3.0.CO;2-M>CrossRefGoogle Scholar
National Cancer Institute (1982) Working formulation. The non-Hodgkin's lymphoma pathologic classification project, sponsored study. Cancer, 49: 2112–2135.Google Scholar
Nichols, R. D., Rebuck, J. W. and Sullivan, J. C.Lymphoma and the parotid gland. Laryngoscope 1982, 92: 365–70.CrossRefGoogle ScholarPubMed
Rappaport, H. (1966) Atlas of Tumour Pathology, section 3, fasci-cle 8, US Armed Forces Institute of Pathology, Washington DC.Google Scholar
Robbins, K. T., Fuller, L. M., Vlasak, M., Osbourne, B., Jing, B. S., Velasquez, W. S. and Sullivan, J. A. (1985) Primary lympho-mas of the nasal cavity and paranasal sinuses. Cancer, 56: 814–819.3.0.CO;2-P>CrossRefGoogle ScholarPubMed
Vyth-Dreese, F. A. and De Vries, J. E. (1982) Human T-cell leukaemia virus in lymphocytes from T-cell leukaemia patient originating from Surinam. Lancet, 2: 993.CrossRefGoogle Scholar
Warnke, R. A., Gatter, K. C., Falini, B., Hildreth, P. L., Wool-ston, R. E., Pulford, K., Cordell, J. L., Cohen, B., De Wolf-Peeters, C. and Mason, D. Y. (1983) Diagnosis of human lym-phoma with monoclonal antileukocyte antibodies. New England Journal of Medicine, 309: 1275–1281.CrossRefGoogle Scholar