Hostname: page-component-6766d58669-88psn Total loading time: 0 Render date: 2026-05-20T00:04:09.667Z Has data issue: false hasContentIssue false
  • English
  • Français

Is otosclerosis a generalized connective tissue disorder?

Biophysical and biochemical studies of skin biopsies from patients with otosclerosis

Published online by Cambridge University Press:  29 June 2007

H. Oxlund ,
U. Pedersen ,
C. C. Danielsen ,
I. Oxlund  and
O. Elbrønd
H. Oxlund*
Affiliation:
Department of Connective Tissue Biology, Institute of Anatomy, University of Aarhus, DK-8000 Aarhus, Denmark.
U. Pedersen
Affiliation:
Department of Otorhinolaryngology, Aarhus Kommunehospital, University of Aarhus, DK-8000 Aarhus, Denmark.
C. C. Danielsen
Affiliation:
Department of Connective Tissue Biology, Institute of Anatomy, University of Aarhus, DK-8000 Aarhus, Denmark.
I. Oxlund
Affiliation:
Department of Otorhinolaryngology, Aarhus Kommunehospital, University of Aarhus, DK-8000 Aarhus, Denmark.
O. Elbrønd
Affiliation:
Department of Otorhinolaryngology, Aarhus Kommunehospital, University of Aarhus, DK-8000 Aarhus, Denmark.
*
Mr. Hans Oxlund, M.D., Ph.D., Chairman, Department of Connective Tissue Biology, Institute of Anatomy, University of Aarhus, DK-8000 Aarhus C, Denmark.
Get access Rights & Permissions [Opens in a new window]

Abstract

It has been suggested that otosclerosis might be caused by a generalized disorder in the connective tissue.

The biophysical and biochemical properties of skin biopsies from twelve patients with otosclerosis and twelve age- and sex-matched controls were investigated. No differences were found in skin strength and extensibility, skin thickness, collagen content, the relationship between collagen type I and type III, reducible collagen cross-links and molecular stability of collagen type I of samples from patients with otosclerosis as compared with those from the controls. The present study does not support the suggestion that otosclerosis might be a generalized connective tissue disorder.

Information

Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 101 , Issue 4 , April 1987 , pp. 307 - 311
Copyright
Copyright © JLO (1984) Limited 1987

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

Altmann, F. and Kornfeld, M. (1967) Osteogenesis imperfecta and otosclerosis: new investigations. Annals of Otology, Rhinology and Laryngology, 76: 89–104.CrossRefGoogle ScholarPubMed
Bailey, A. J., Peach, C. M. and Fowler, J. L. (1970) Chemistry of the collagen cross-links. Isolation and characterization of two intermediate intermolcular cross-links in collagen. Biochemical Journal, 117: 819–831.CrossRefGoogle Scholar
Bentzen, O. (1961) Skin anomalies in otosclerosis. 7e Congresse Internationale de oto-rhino-laryngologie, Paris. Excerpta Medica International Congress Series, 35: 40–41.Google Scholar
Bentzen, O. (1981) Otosklerose—eine Allgemeinerkrankung. HNO Praxis, 6: 4–11.Google Scholar
Bentzen, O. (1982) Sensorineural hearing loss and somatic insufficiency. Audiology, 21: 97–110.CrossRefGoogle ScholarPubMed
Bretlau, O. and Jørgensen, M. B. (1969) Otosclerosis and osteogenesis imperfecta. Archives of Otolaryngology, 90: 4–10.CrossRefGoogle ScholarPubMed
Danielsen, C. C. (1982a) Precision method to determine denaturation temperature of collagen using ultraviolet difference spectroscopy. Collagen Related Research, 2: 143–150.CrossRefGoogle ScholarPubMed
Danielsen, C. C. (1982b) Difference in thermal stability of type-I and type-III collagen from rat skin. Biochemical Journal, 203: 323–326.CrossRefGoogle ScholarPubMed
Hanson, A. N. and Bentley, J. P. (1983) Quantitation of type I to type III collagen ratios in small samples of human tendon, blood vessels and atherosclerotic plaque. Analytical Biochemistry, 130: 32–40.CrossRefGoogle ScholarPubMed
Light, N. D. and Bailey, A. J. (1979) Changes in crosslinking during aging in bovine tendon collagen. Febs letters, 97: 183–188.CrossRefGoogle ScholarPubMed
Oxlund, H., Manthorpe, R. and Viidik, A. (1981) The biomechanical properties of connective tissue in rabbits as influenced by short-term glucocorticoid treatment. Journal of Biomechanics, 14: 129–133.CrossRefGoogle ScholarPubMed
Oxlund, H., Sims, T. and Light, N. D. (1982) Changes in mechanical properties, thermal stability, reducible cross-links and glycosyl-lysines in rat skin induced by corticosteroid treatment. Acta Endocrinologica, 101: 312–320.Google ScholarPubMed
Oxlund, H., Pedersen, U., Danielsen, C. C., Oxlund, I. and Elbrønd, O. (1985) Reduced strength of skin in osteogenesis imperfecta. European Journal of Clinical Investigation, 15: 408–411.CrossRefGoogle ScholarPubMed
von Pavlov, V., Fitscheva, M. and Zener, I. V. (1981) Befunde an den kollagenen fasern der haut bei otosclerosekranken. HNO Praxis, 6: 12–16.Google Scholar
Pedersen, U., Melsen, F., Elbrønd, O. and Charles, P. (1985) Histopathology of the stapes in osteogenesis imperfecta. Journal of Laryngology and Otology, 99: 451–458.CrossRefGoogle ScholarPubMed
Reiser, K. M. and Last, J. A. (1983) Anomalous electrophoretic behavior of a cyanogen bromide peptide from type III collagen. Connective Tissue Research, 12: 1–16.CrossRefGoogle ScholarPubMed
Robins, S. P., Shimokomaki, M. and Bailey, A. J. (1973) The chemistry of the collagen cross-links. Age-related changes in the reducible components of intact bovine collagen fibres. Biochemical Journal, 131: 771–780.CrossRefGoogle ScholarPubMed
Sokal, R. R. and Rohlf, J. (1981) Biometry. W H Freeman and Co., San Francisco.Google Scholar
Woessner, J. F. (1976) Determination of hydroxy-proline in connective tissues. In: Hall, D. A. (ed.). The methodology of connective tissue research. Joynson-Bruwers Ltd; Oxford: pp. 227–233.Google Scholar