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Exploring the association between prior cancer history and risk of head and neck cancer: insights from a multi-centre retrospective case–control study

Published online by Cambridge University Press:  11 November 2024

Sabina Dranova Open the ORCID record for Sabina Dranova [Opens in a new window] ,
Zohaib Siddiqui Open the ORCID record for Zohaib Siddiqui [Opens in a new window] ,
Sterling Roberts ,
Numrah Hussan  and
Emma Molena
Sabina Dranova*
Affiliation:
ENT Department, Medway Maritime Hospital NHS Trust, UK
Zohaib Siddiqui
Affiliation:
ENT Department, Frimley Health NHS Foundation Trust, Frimley, UK
Sterling Roberts
Affiliation:
ENT Department, Medway Maritime Hospital NHS Trust, UK
Numrah Hussan
Affiliation:
Accident and Emergency Department, Royal Surrey Hospital NHS Trust , Guildford, UK
Emma Molena
Affiliation:
ENT Department, Medway Maritime Hospital NHS Trust, UK
*
Corresponding author: Sabina Dranova; Email: neosabina@inbox.lv
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Abstract

Objective

This study investigates the association between a history of previous cancers and the subsequent risk of developing head and neck cancer.

Method

A retrospective case–control design was employed, analysing 561 patient records from two National Health Service hospitals, with 273 patients diagnosed with head and neck cancer and 288 patients serving as controls.

Results

Statistical analysis revealed a significant association between prior cancer history, particularly squamous cell carcinoma (SCC), and increased risk of developing head and neck cancer (p < 0.05). Subtype analysis highlighted specific head and neck cancers, such as oropharyngeal and laryngeal cancers, as particularly associated with a history of SCC.

Conclusion

The findings suggest that previous cancer diagnoses, especially SCC, may predispose individuals to head and neck cancer, challenging the traditional focus on tobacco, alcohol and human papillomavirus as primary risk factors. These results underscore the need for incorporating prior cancer history into risk assessment protocols and surveillance strategies to improve early detection and patient outcomes.

Keywords

CarcinomaSquamous CellNeoplasmsRisk factorsOropharynxLarynxRecurrenceRisk assessment

Information

Type
Main Article
Information
The Journal of Laryngology & Otology , Volume 139 , Issue 7 , July 2025 , pp. 610 - 614
Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED.

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Footnotes

Sabina Dranova takes responsibility for the integrity of the content of the paper

References

Cancer Research UK. Head and Neck Cancers Statistics. 2021Google Scholar
Gormley, M, Creaney, G, Schache, A, Ingarfield, K, Conway, DI. Reviewing the epidemiology of head and neck cancer: definitions, trends, and risk factors. Br Dent J 2022;233:780–6CrossRefGoogle ScholarPubMed
Gislon, LC, Curado, MP, López, RVM, de Oliveira, JC, Vasconcelos de Podestá, JR, Ventorin von Zeidler, S, et al. Risk factors associated with head and neck cancer in former smokers: a Brazilian multicentric study. Cancer Epidemiol 2022;78:102143CrossRefGoogle ScholarPubMed
Hashibe, M, Brennan, P, Benhamou, S, Castellsague, X, Chen, C, Curado, MP, et al. Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. J Natl Cancer Inst 2007;99:777–89CrossRefGoogle ScholarPubMed
Cillo, AR, Kürten, CHL, Tabib, T, Qi, Z, Onkar, S, Wang, T, et al. Immune landscape of viral- and carcinogen-driven head and neck cancer. Immunity 2020;52:183CrossRefGoogle ScholarPubMed
HPV Vaccine May Prevent Oral HPV Infection. NCIGoogle Scholar
DeKloe, J, Urdang, ZD, Martinez Outschoorn, UE, Curry, JM. Effects of HPV vaccination on the development of HPV-related cancers: a retrospective analysis of a United States-based cohort. J Clin Oncol 2024;42:10507CrossRefGoogle Scholar
Heck, JE, Berthiller, J, Vaccarella, S, Winn, DM, Smith, EM, Shan’gina, O, et al. Sexual behaviours and the risk of head and neck cancers: a pooled analysis in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. Int J Epidemiol 2010;39:166–81CrossRefGoogle ScholarPubMed
Kian, Ang KHarris, J, Wheeler, R, Weber, R, Rosenthal, DI, Nguyen-Tân, F, et al. Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med 2010;363(1):24–35Google Scholar
Mowery, A, Conlin, M, Clayburgh, D. Risk of head and neck cancer in patients with prior hematologic malignant tumors. JAMA Otolaryngol Head Neck Surg 2019;145:1121CrossRefGoogle ScholarPubMed
Kim, SY, Kim, GJ, Bang, JI, Il, Shin H, Sun D, Il. Are second primary head and neck cancers with previous hematological malignancy more aggressive than de novo head and neck cancers? Am J Otolaryngol 2023;44:103748CrossRefGoogle ScholarPubMed
Holm, L-E. Cancer occurring after radiotherapy and chemotherapy. Int J Radiat Oncol Biol Phys 1990;19:1303–8CrossRefGoogle ScholarPubMed
Siddiqui, Z, Hamid, M, Caton, N, Cheang, P-P. Head and neck cancer: a 6-year retrospective analysis and review of three common triaging systems. Clin Otolaryngol 2023;48(4):630–7CrossRefGoogle ScholarPubMed