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p53 and bcl-2 expression and argyrophilic nucleolar organizer regions in patients with malignant maxillary sinus tumours

Published online by Cambridge University Press:  29 June 2007

Torahiko Nakashima ,
Tadashi Nakashima ,
Muneyuki Masuda  and
Sohtaro Komiyama
Torahiko Nakashima*
Affiliation:
Departments of Otorhinolaryngology, Faculty of Medicine, Kyushu, Japan.
Tadashi Nakashima
Affiliation:
Kyushu University and the National Kyushu Cancer Center, Kyushu, Japan.
Muneyuki Masuda
Affiliation:
Departments of Otorhinolaryngology, Faculty of Medicine, Kyushu, Japan.
Sohtaro Komiyama
Affiliation:
Departments of Otorhinolaryngology, Faculty of Medicine, Kyushu, Japan.
*
Address for correspondence: Torahiko Nakashima, 3-1-1 Maidashi Higashi-ku, Fukuoka City, Japan 812. Fax: 81-92-651-0975
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Abstract

To investigate the relation between the clinicopathological findings, and the survival of patients with malignant tumours of the maxillary sinus, and the tumour's biological parameters, we examined the expression of p53 and bcl-2 and the number of silver-stainable nucleolar organizer regions (AgNORs) in 23 paraffin-embedded specimens from primary tumours. Fifteen of 23 (65 per cent) maxillary tumours expressed p53 and two of 23 (nine per cent) tumours expressed the bcl-2 gene product. The mean number of AgNORs per nucleus was 5.2 ± 2.4. There was no relationship between the expression of p53 or bcl-2 and the patient's clinical course. In contrast, there was a statistically significant difference in the survival of patients with a high (>6) number of AgNORs and patients with a low (<6) number of AgNORs. These data suggest that the number of AgNORs may be useful in evaluating the prognosis of patients with malignant maxillary sinus tumours.

Keywords

Maxillary sinus neoplasmsProteinp 53bcl-2; Nucleolus organizer region

Information

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 111 , Issue 1 , January 1997 , pp. 38 - 42
Copyright
Copyright © JLO (1984) Limited 1997

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