Immobility and ICU-Acquired Weakness

doi:10.1017/9781009501477.005

Chapter 4 - Immobility and ICU-Acquired Weakness

from Section 2 - The Hazards of Hospitalization

Published online by Cambridge University Press: 22 January 2026

Felipe González-Seguel ,

Kirby P. Mayer and

Edited by

Brad W. Butcher: Affiliation:
University of Pittsburgh School of Medicine, Pennsylvania

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Summary

This chapter illustrates the harmful impact of bed rest and immobilization on body systems, including the cardiovascular, respiratory, metabolic, neurological, and musculoskeletal systems. These changes are likely to contribute to Intensive Care Unit Acquired Weakness (ICUAW), which is an umbrella term for critical illness polyneuropathy, myopathy, and muscle atrophy. Other risk factors include illness severity, baseline characteristics, and social determinants of health, along with drug use and organ support during critical illness. ICUAW is currently diagnosed using the Medical Research Council Sum-Score which rates 6 bilateral muscle groups from 0 (no contraction) to 5 (normal strength); a score of less than 48 points out of 60 defines clinical weakness. ICUAW is associated with increased short- and long-term morbidity and mortality, making it a substantial contributor to poor outcomes after the ICU, including post-intensive care syndrome.

Keywords

Bed Rest Immobilization Intensive Care Unit Acquired Weakness

Information

Type: Chapter
Information: Post-Intensive Care Syndrome
A Practical Approach
, pp. 45 - 60

DOI: https://doi.org/10.1017/9781009501477.005 [Opens in a new window]

Publisher: Cambridge University Press

Print publication year: 2026

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