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Volga German surnames and Alzheimer’s disease in Argentina: an epidemiological perspective

Published online by Cambridge University Press:  29 April 2024

Arturo Leonardo Morales Open the ORCID record for Arturo Leonardo Morales [Opens in a new window] ,
Marcelo Isidro Figueroa Open the ORCID record for Marcelo Isidro Figueroa [Opens in a new window] ,
Pablo Navarro Open the ORCID record for Pablo Navarro [Opens in a new window] ,
Estela Raquel Chaves ,
Anahí Ruderman Open the ORCID record for Anahí Ruderman [Opens in a new window] ,
José Edgardo Dipierri Open the ORCID record for José Edgardo Dipierri [Opens in a new window]  and
Virginia Ramallo Open the ORCID record for Virginia Ramallo [Opens in a new window]
Arturo Leonardo Morales
Affiliation:
Instituto Patagónico de Ciencias Sociales y Humanas (IPCSH), Centro Nacional Patagónico, Consejo Nacional de Investigaciones Científicas y Técnicas, Puerto Madryn, Argentina Laboratorio de Ciencias de las Imágenes, Departamento de Ingeniería Eléctrica y Computadoras, Universidad Nacional del Sur, Bahía Blanca, Argentina Departamento de Informática, Facultad de Ingeniería, Universidad Nacional de la Patagonia San Juan Bosco, Trelew, Argentina Programa de Referencia y Biobanco Genómico de la Población Argentina (PoblAr), Buenos Aires, Argentina
Marcelo Isidro Figueroa
Affiliation:
Unidad de Genética, Hospital Materno Infantil Doctor Hector Quintana, San Salvador de Jujuy, Argentina Instituto de Ecorregiones Andinas, Universidad Nacional de Jujuy-CONICET, San Salvador de Jujuy, Argentina
Pablo Navarro
Affiliation:
Instituto Patagónico de Ciencias Sociales y Humanas (IPCSH), Centro Nacional Patagónico, Consejo Nacional de Investigaciones Científicas y Técnicas, Puerto Madryn, Argentina Laboratorio de Ciencias de las Imágenes, Departamento de Ingeniería Eléctrica y Computadoras, Universidad Nacional del Sur, Bahía Blanca, Argentina Departamento de Informática, Facultad de Ingeniería, Universidad Nacional de la Patagonia San Juan Bosco, Trelew, Argentina Programa de Referencia y Biobanco Genómico de la Población Argentina (PoblAr), Buenos Aires, Argentina
Estela Raquel Chaves
Affiliation:
Instituto de Biología de la Altura, Universidad Nacional de Jujuy, San Salvador de Jujuy, Argentina
Anahí Ruderman
Affiliation:
Instituto Patagónico de Ciencias Sociales y Humanas (IPCSH), Centro Nacional Patagónico, Consejo Nacional de Investigaciones Científicas y Técnicas, Puerto Madryn, Argentina Programa de Referencia y Biobanco Genómico de la Población Argentina (PoblAr), Buenos Aires, Argentina
José Edgardo Dipierri
Affiliation:
Programa de Referencia y Biobanco Genómico de la Población Argentina (PoblAr), Buenos Aires, Argentina Unidad de Genética, Hospital Materno Infantil Doctor Hector Quintana, San Salvador de Jujuy, Argentina
Virginia Ramallo*
Affiliation:
Instituto Patagónico de Ciencias Sociales y Humanas (IPCSH), Centro Nacional Patagónico, Consejo Nacional de Investigaciones Científicas y Técnicas, Puerto Madryn, Argentina Programa de Referencia y Biobanco Genómico de la Población Argentina (PoblAr), Buenos Aires, Argentina
*
Corresponding author: Virginia Ramallo; Email: ramallo@cenpat-conicet.gob.ar
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Abstract

The N141I variant (PSEN1 gene) is associated with familial forms of early-onset Alzheimer’s disease (AD) in descendants of Volga Germans, whose migration to Argentina is well documented. As a proxy for geographic origin, surnames can be a valuable tool in population studies. The 2015 Argentine Electoral Registry provided geographic data for 30,530,194 individuals, including 326,922 with Volga German surnames. Between 2005 and 2017, the Ministry of Health recorded 4,115,216 deaths, of which 17,226 were attributed to AD and related causes. The study used both diachronic and synchronic data to identify patterns of territorial distribution and co-spatiality, using Moran’s I and generalised linear model statistics. The frequency of surnames of Volga German origin accounts for 43.53% of the variation in deaths from AD and three clusters of high non-random frequency were found. Almost 150 years later, people descending from the Volga migration remain highly concentrated and may have a different risk of developing AD. The identification of spatial patterns provides reliable guidance for medical research and highlights the importance of specific health policies for particular populations.

Keywords

surname analysesepidemiologyVolga migration-descendedAlzheimer’s disease

Information

Type
Research Article
Information
Journal of Biosocial Science , Volume 56 , Issue 4 , July 2024 , pp. 625 - 638
Copyright
© The Author(s), 2024. Published by Cambridge University Press

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Footnotes

†

Arturo Leonardo Morales and Marcelo Isidro Figueroa contributed equally to this manuscript.

References

Akushevich, I, Kravchenko, J, Yashkin, A, Doraiswamy, PM, Hill, CV, and Alzheimer’s Disease and Related Dementia Health Disparities Collaborative Group (2023) Alzheimer’s Disease and Related Dementia Health Disparities Collaborative Group. Expanding the scope of health disparities research in Alzheimer’s disease and related dementias: Recommendations from the “Leveraging Existing Data and Analytic Methods for Health Disparities Research Related to Aging and Alzheimer’s Disease and Related Dementias” Workshop Series. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association 15(1), e12415. https://doi.org/10.1002/dad2.12415 Google Scholar
Albeck, ME, Alfaro, EL, Dipierri, JE, and Chaves, ER (2017) Los apellidos de Salta en el siglo XXI: origen geo-lingüítico, diversidad y frecuencia. Andes 28(2), 2–21. https://www.redalyc.org/articulo.oa?id=12755958008.Google Scholar
Alzheimer’s Association (2020) 2020 Alzheimer’s disease facts and figures. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association 16(3), 391–460. https://doi.org/10.1002/alz.12068 CrossRefGoogle Scholar
Andrade-Guerrero, J, Santiago-Balmaseda, A, Jeronimo-Aguilar, P, Vargas-Rodríguez, I, Cadena-Suárez, AR, Sánchez-Garibay, C, Pozo-Molina, G, Méndez-Catalá, CF, Cardenas-Aguayo, MD, Diaz-Cintra, S, Pacheco-Herrero, M, Luna-Muñoz, J, and Soto-Rojas, LO (2023) Alzheimer’s disease: an updated overview of its genetics. International Journal of Molecular Sciences 24(4), 3754. https://doi.org/10.3390/ijms24043754 CrossRefGoogle ScholarPubMed
Anselin, L (1995) Local indicators of spatial association—LISA. Geographical Analysis 27, 93–115. https://doi.org/10.1111/j.1538-4632.1995.tb00338.x CrossRefGoogle Scholar
AufderHeide, E (2006) Representations of German-Speaking Exiles and Immigrants in Argentina [Bowling Green State University/OhioLINK]. URL: http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1162858784 Google Scholar
Bateman, RJ, Aisen, PS, De Strooper, B, Fox, NC, Lemere, CA, Ringman, JM, Salloway, S, Sperling, RA, Windisch, M, and Xiong, C (2011) Autosomal-dominant Alzheimer’s disease: a review and proposal for the prevention of Alzheimer’s disease. Alzheimer’s Research & Therapy 3(1), 1. https://doi.org/10.1186/alzrt59 Google ScholarPubMed
Bickel, H (2000) Dementia syndrome and Alzheimer disease: an assessment of morbidity and annual incidence in Germany. Gesundheitswesen 62(4), 211–218. https://doi.org/10.1055/s-2000-10858 CrossRefGoogle ScholarPubMed
Bird, TD, Lampe, TH, Nemens, EJ, Miner, GW, Sumi, SM, and Schellenberg, GD (1988) Familial Alzheimer’s disease in American descendants of the Volga Germans: probable genetic founder effect. Annals of Neurology 23(1), 25–31. https://doi.org/10.1002/ana.410230106 CrossRefGoogle ScholarPubMed
Bird, TD, Nemens, EM, Nochlin, D, Sumi, SM, Wijsman, EM, and Schellenberg, GD (1992) Familial Alzheimer’s disease in Germans from Russia: a model of genetic heterogeneity in Alzheimer’s disease. Heterogeneity of Alzheimer’s Disease. In Research and Perspectives in Alzheimer’s Disease. Berlin, Heidelberg: Springer. https://doi.org/10.1007/978-3-642-46776-9_13 Google Scholar
Blauwendraat, C, Wilke, C, Jansen, IE, Schulte, C, Simón-Sánchez, J, Metzger, FG, Bender, B, Gasser, T, Maetzler, W, Rizzu, P, Heutink, P, and Synofzik, M (2016) Pilot whole-exome sequencing of a German early-onset Alzheimer’s disease cohort reveals a substantial frequency of PSEN2 variants. Neurobiology of Aging, 37, 208.e11–208.e17. https://doi.org/10.1016/j.neurobiolaging.2015.09.016 CrossRefGoogle Scholar
Chêne, G, Beiser, A, Au, R, Preis, SR, Wolf, PA, Dufouil, C, and Seshadri, S (2015) Gender and incidence of dementia in the Framingham Heart Study from mid-adult life. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association 11(3), 310–320. https://doi.org/10.1016/j.jalz.2013.10.005 CrossRefGoogle ScholarPubMed
Dalmasso, MC, de Rojas, I, Olivar, N, Muchnik, C, Angel, B, Gloger, S, Sanchez Abalos, MS, Chacón, MV, Aránguiz, R, Orellana, P, Cuesta, C, Galeano, P, Campanelli, L, Novack, GV, Martinez, LE, Medel, N, Lisso, J, Sevillano, Z, Irureta, N, Castaño, EM, Montrreal, L, Thoenes, M, Hanses, C, Heilmann-Heimbach, S, Kairiyama, C, Mintz, I, Villella, I, Rueda, F, Romero, A, Wukitsevits, N, Quiroga, I, Gona, C, Lambert, JC, Solis, P, Politis, DG, Mangone, CA, Gonzalez-Billault, C, Boada, M, Tàrraga, L, Slachevsky, A, Albala, C, Fuentes, P, Kochen, S, Brusco, LI, Ruiz, A, Morelli, L, and Ramírez, A (2023) The first genome-wide association study in the Argentinian and Chilean populations identifies shared genetics with Europeans in Alzheimer’s disease. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association. 10.1002/alz.13522. Advance online publication. https://doi.org/10.1002/alz.13522 CrossRefGoogle ScholarPubMed
de Flachs, MCV (1994) Emigraciones transoceánicas. Los alemanes en América. 1850-1914. El caso argentino. Cuadernos de Historia Contemporánea 16, 65.Google Scholar
Dehghani, N, Bras, J, and Guerreiro, R (2021) Erratum to: How understudied populations have contributed to our understanding of Alzheimer’s disease genetics. Brain 144(8), e69. https://doi.org/10.1093/brain/awab028 CrossRefGoogle ScholarPubMed
Dirección de Estadísticas e Información de la Salud – DEIS (2023) Bases de datos de defunciones. URL: https://www.argentina.gob.ar/salud/deis/datos/defunciones (accessed on 02nd April 2023).Google Scholar
Dräger, K, and Schmuck, M (2009) The German Surname Atlas Project—Computer-based surname geography, Mainz. Available from: https://www.germanistik.uni-mainz.de/files/2015/01/Dr%C3%A4ger-Schmuck2009.pdf.Google Scholar
García, MJ, and Comesaña, A (2021) Prevalence of neurocognitive disorders in a rural area of Argentina. Revista de la Facultad de Ciencias Medicas 78(4), 347–352.10.31053/1853.0605.v78.n4.32965CrossRefGoogle Scholar
Gushulak, BD, and MacPherson, DW (2006) The basic principles of migration health: population mobility and gaps in disease prevalence. Emerging Themes in Epidemiology 3, 3. https://doi.org/10.1186/1742-7622-3-3 CrossRefGoogle ScholarPubMed
Hipperdinger, YH (2017) Las lenguas inmigratorias en la Argentina: El caso de los alemanes del Volga. Sociedad y Discurso 30, 92–114. https://doi.org/10.5278/ojs.s%20&%20d.v0i30.1851 Google Scholar
Instituto Nacional de Estadísticas y Censos de la República Argentina – INDEC (2023) Estadísticas de población por año y región. URL: https://www.indec.gob.ar/indec/web/Nivel3-Tema-2-41 (accessed on 15th November 2023).Google Scholar
Itzcovich, T, Chrem-Méndez, P, Vázquez, S, Barbieri-Kennedy, M, Niikado, M, Martinetto, H, Allegri, R, Sevlever, G, and Surace, EI (2020) A novel mutation in PSEN1 (p.T119I) in an Argentine family with early- and late-onset Alzheimer’s disease. Neurobiology of Aging 85, 155.e9–155.e12. https://doi.org/10.1016/j.neurobiolaging.2019.05.001 CrossRefGoogle Scholar
Konig, W (1978) dtv-Atlas zur deutschen Sprache (First Edition). Deutscher Taschenbuch Verlag, Munich.Google Scholar
Lange, L, Schulte, T, Dittmann, B, and Hildebrandt, H (2017) 2 Regionale Verteilung der Demenz sowie Inanspruchnahme vor und nach Erstdiagnose. Monitor Versorgungsforschung 41–46. https://doi.org/10.24945/MVF.05.18.1866-0533.2098 Google Scholar
Larraya, FP, Grasso, L, and Marí, G (2004) Prevalence of dementia of the Alzheimre type, vascular dementia and other DSM-IV and ICD-10 dementias in the Republica Argentina. Revista Neurologica Argentina 29, 148–153.Google Scholar
Llibre-Guerra, JJ, Li, Y, Allegri, RF, Mendez, PC, Surace, EI, Llibre-Rodriguez, JJ, Sosa, AL, Aláez-Verson, C, Longoria, EM, Tellez, A, Carrillo-Sánchez, K, Flores-Lagunes, LL, Sánchez, V, Takada, LT, Nitrini, R, Ferreira-Frota, NA, Benevides-Lima, J, Lopera, F, Ramírez, L, Jiménez-Velázquez, I, Schenk, C, Acosta, D, Behrens, MI, Doering, M, Ziegemeier, E, Morris, JC, McDade, E, and Bateman, RJ (2020) Dominantly inherited Alzheimer’s disease in Latin America: genetic heterogeneity and clinical phenotypes. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association 17(4), 653–664. https://doi.org/10.1002/alz.12227 CrossRefGoogle ScholarPubMed
Luisi, P, García, A, Berros, JM, Motti, JMB, Demarchi, DA, Alfaro, E, Aquilano, E, Argüelles, C, Avena, S, Bailliet, G, Beltramo, J, Bravi, CM, Cuello, M, Dejean, C, Dipierri, JE, Jurado Medina, LS, Lanata, JL, Muzzio, M, Parolin, ML, Pauro, M, Paz Sepúlveda, PB, Rodríguez Golpe, D, Santos, MR, Schwab, M, Silvero, N, Zubrzycki, J, Ramallo, V, and Dopazo, H (2020) Fine-scale genomic analyses of admixed individuals reveal unrecognized genetic ancestry components in Argentina. PloS One 15(7), e0233808. https://doi.org/10.1371/journal.pone.0233808 CrossRefGoogle ScholarPubMed
Mateos, P (2014) Names, Ethnicity and Populations. Series: Advances in Spatial Science. Berlin and Heidelberg, Germany: Springer. ISBN: 978-3-642-45412-710.1007/978-3-642-45413-4CrossRefGoogle Scholar
Melcon, CM, Bartoloni, L, Katz, M, Del Mónaco, R, Mangone, CA, Melcon, MO, and Allegri, RF (2010) Propuesta de un Registro centralizado de casos con Deterioro Cognitivo en Argentina (ReDeCAr) basado en el Sistema Nacional de Vigilancia Epidemiológica. Neurología Argentina 2(3), 161–166.10.1016/S1853-0028(10)70053-7CrossRefGoogle Scholar
Méndez, PC, Calandri, I, Nahas, F, Russo, MJ, Demey, I, Martín, ME, Clarens, MF, Harris, P, Tapajoz, F, Campos, J, Surace, EI, Martinetto, H, Ventrice, F, Cohen, G, Vázquez, S, Romero, C, Guinjoan, S, Allegri, RF, and Sevlever, G (2018) Argentina-Alzheimer’s disease neuroimaging initiative (Arg-ADNI): neuropsychological evolution profile after one-year follow up. Arquivos de neuro-psiquiatria 76(4), 231–240. https://doi.org/10.1590/0004-282x20180025 CrossRefGoogle Scholar
Morales, AL, Navarro, P, Cintas, C, González-José, R, Ramallo, V, and Delrieux, C (2021) Bulsarapp: interactive visual analysis for surname trend exploration. IEEE Computer Graphics and Applications 42, 28–33.10.1109/MCG.2021.3115052CrossRefGoogle Scholar
Muchnik, C, Olivar, N, Dalmasso, MC, Azurmendi, PJ, Liberczuk, C, Morelli, L, and Brusco, LI (2015) Identification of PSEN2 mutation p.N141I in Argentine pedigrees with early-onset familial Alzheimer’s Disease. Neurobiology of Aging 36(10), 2674–7.e1. https://doi.org/10.1016/j.neurobiolaging.2015.06.011 CrossRefGoogle ScholarPubMed
Muzzio, M, Motti, JMB, Paz Sepulveda, PB, Yee, MC, Cooke, T, Santos, MR, Ramallo, V, Alfaro, EL, Dipierri, JE, Bailliet, G, Bravi, CM, Bustamante, CD, and Kenny, EE (2018) Population structure in Argentina. PLoS One 13(5), e0196325. https://doi.org/10.1371/journal.pone.0196325 CrossRefGoogle ScholarPubMed
Pohl, JO (2009) Volk auf dem Weg: transnational migration of the Russian-Germans from 1763 to the present day. Studies in Ethnicity and Nationalism 9(2), 267–286.10.1111/j.1754-9469.2009.01050.xCrossRefGoogle Scholar
Rodriguez-Larralde, A, Barrai, I, Nesti, C, Mamolini, E, and Scapoli, C (1998) Isonymy and isolation by distance in Germany. Human Biology 70(6), 1041–1056.Google ScholarPubMed
Yu, CE, Marchani, E, Nikisch, G, Müller, U, Nolte, D, Hertel, A, Wijsman, EM, and Bird, TD (2010) The N141I mutation in PSEN2: implications for the quintessential case of Alzheimer disease. Archives of Neurology 67(5), 631–633. https://doi.org/10.1001/archneurol.2010.87 CrossRefGoogle ScholarPubMed
Ziegler, U, and Doblhammer, G (2009) Prävalenz und Inzidenz von Demenz in Deutschland–Eine Studie auf Basis von Daten der gesetzlichen Krankenversicherungen von 2002. Das Gesundheitswesen 71(05), 281–290.10.1055/s-0028-1119384CrossRefGoogle ScholarPubMed