Molecular Biology and Human Diversity

doi:10.1017/CBO9780511525643

Considerable attention is being paid to the use of molecular evidence in studies of human diversity and origins. Much of the early work was based on evidence from mitochondrial DNA, but this has been supplemented by important information from nuclear DNA from both the Y chromosomes and the autosomes. The bulk of the material available is also from living populations, but this is being extended by the study of DNA from archaic populations. The underlying models used in interpreting this evidence are developments of the neutral theory of molecular evolution, but also consider the possible role of selection. This 1996 volume brings together evidence from an international group of research workers. It will be an important reference for researchers in human biology, molecular biology and genetics alike.

"All in all, this book is a fair and useful representation of our knowledge of human genetic diversity near the end of this century." The Quarterly Review of Biology

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Contents

Frontmatter
pp i-vi
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Contents
pp vii-viii
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List of contributors
pp ix-xiv
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Preface
pp xv-xvi
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1 - Mitochondrial DNA in ancient and modern humans
pp 1-11
- By E. Hagelberg
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2 - Digital DNA typing of human paternal lineages
pp 12-23
- By M. A. Jobling, N. Bouzekri, N. Fretwell, G. A. Dover, A. J. Jeffreys
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3 - Minisatellites as tools for population genetic analysis
pp 24-28
- By J. Flint, J. Bond, R. M. Harding, J. B. Clegg
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4 - DNA fingerprinting: development of a technology and its application to the study of human populations
pp 29-50
- By A. P. Ryskov, M. I. Prosnyak, N. S. Kupriyanova, E. K. Khusnutdinova, I. M. Khidiatova, V. V. Kalnin, O. V. Kalnina, K. B. Bulayeva, S. A. Limborska
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5 - Kinship, inbreeding, and matching probabilities
pp 51-62
- By N. E. Morton, J. W. Teague
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6 - Using the coalescent to interpret gene trees
pp 63-80
- By R. M. Harding
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7 - Some attempts at measuring natural selection by malaria
pp 81-92
- By A. V. S. Hill
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8 - AIDA: Geographical patterns of DNA diversity investigated by autocorrelation statistics
pp 93-111
- By G. Barbujani, G. Bertorelle, To Andrea Marconato (1957–1995) and to Mariella
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9 - Mitochondrial DNA sequences in Europe: an insight into population history
pp 112-129
- By J. Bertranpetit, F. Calafell, D. Comas, A. Pérez-Lezaun, E. Mateu
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10 - Palaeolithic and neolithic contributions to the European mitochondrial gene pool
pp 130-140
- By B. Sykes, H. Côrte-Real, M. Richards
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11 - The molecular diversity of the Niokholo Mandenkalu from Eastern Senegal: an insight into West Africa genetic history
pp 141-155
- By L. Excoffier, E. S. Poloni, S. Santachiara-Benerecetti, O. Semino, A. Langaney
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12 - The peopling of Madagascar
pp 156-170
- By H. Soodyall, T. Jenkins, R. Hewitt, A. Krause, M. Stoneking
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13 - Molecular perspectives on the colonisation of the Pacific
pp 171-195
- By J. J. Martinson
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14 - Population ancestry on Tristan da Cunha–the evidence of the individual
pp 196-204
- By D. F. Roberts, H. Soodyall
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15 - Linguistic divergence and genetic evolution: a molecular perspective from the New World
pp 205-224
- By R. H. Ward
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16 - Allelic sequence diversity at the human β-globin locus
pp 225-241
- By S. M. Fullerton
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17 - A nuclear perspective on human evolution
pp 242-264
- By K. K. Kidd, J. R. Kidd
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18 - Contrasting gene trees and population trees of the evolution of modern humans
pp 265-282
- By N. Saitou
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19 - Methods and models for understanding human diversity
pp 283-299
- By H. Harpending, J. Relethford, S. T. Sherry
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Index
pp 300-305
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Molecular Biology and Human Diversity

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Contents

Frontmatter
pp i-vi

Contents
pp vii-viii

List of contributors
pp ix-xiv

Preface
pp xv-xvi

1 - Mitochondrial DNA in ancient and modern humans
pp 1-11

2 - Digital DNA typing of human paternal lineages
pp 12-23

3 - Minisatellites as tools for population genetic analysis
pp 24-28

4 - DNA fingerprinting: development of a technology and its application to the study of human populations
pp 29-50

5 - Kinship, inbreeding, and matching probabilities
pp 51-62

6 - Using the coalescent to interpret gene trees
pp 63-80

7 - Some attempts at measuring natural selection by malaria
pp 81-92

8 - AIDA: Geographical patterns of DNA diversity investigated by autocorrelation statistics
pp 93-111

9 - Mitochondrial DNA sequences in Europe: an insight into population history
pp 112-129

10 - Palaeolithic and neolithic contributions to the European mitochondrial gene pool
pp 130-140

11 - The molecular diversity of the Niokholo Mandenkalu from Eastern Senegal: an insight into West Africa genetic history
pp 141-155

12 - The peopling of Madagascar
pp 156-170

13 - Molecular perspectives on the colonisation of the Pacific
pp 171-195

14 - Population ancestry on Tristan da Cunha–the evidence of the individual
pp 196-204

15 - Linguistic divergence and genetic evolution: a molecular perspective from the New World
pp 205-224

16 - Allelic sequence diversity at the human β-globin locus
pp 225-241

17 - A nuclear perspective on human evolution
pp 242-264

18 - Contrasting gene trees and population trees of the evolution of modern humans
pp 265-282

19 - Methods and models for understanding human diversity
pp 283-299

Index
pp 300-305

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Molecular Biology and Human Diversity

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