The Biology of Schwann Cells: Development, Differentiation and Immunomodulation

doi:10.1017/CBO9780511541605

Schwann cells are a diverse group of cells formed from neural crest cells. They are essential components of the peripheral nerves of both vertebrate and invertebrate nervous systems. The diversity of Schwann cell subsets and function is seen in those Schwann cells that form myelin - that uniquely specialised part of the plasma membrane that spirals around axonal lengths to myelinate the peripheral nerves. The Biology of Schwann Cells concentrates on the cells of mammals and in particular humans. It covers the distinction between compact and non-compact myelin in depth, along with the perisynaptic cells which form the partnership between nerve terminals and muscle fibre. Developmental aspects are discussed alongside differentiation, and the genetics of the cells in health and disease. With chapters from world-renowned experts, this book is aimed at postgraduates and researchers in neuroscience and neurology and anyone involved in the study of peripheral nerves.

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Contents

Frontmatter
pp i-vi
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Contents
pp vii-viii
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Preface
pp ix-x
- By Patricia J. Armati
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Contributors
pp xi-xiv
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1 - Introduction to the Schwann cell
pp 1-12
- By Emily Mathey, Patricia J. Armati
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2 - Early events in Schwann cell development
pp 13-36
- By Rhona Mirsky, Kristján R. Jessen
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3 - The molecular organisation of myelinating Schwann cells
pp 37-54
- By Edgardo J. Arroyo, Steven S. Scherer
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4 - The role of the extracellular matrix in Schwann cell development and myelination
pp 55-71
- By Maria Laura Feltri, Lawrence Wrabetz
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5 - The biology of perisynaptic (terminal) Schwann cells
pp 72-99
- By Chien-Ping Ko, Yoshie Sugiura, Zhihua Feng
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6 - Cytokine and chemokine interactions with Schwann cells: the neuroimmunology of Schwann cells
pp 100-117
- By Robert P. Lisak, Joyce A. Benjamins
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7 - Schwann cells as immunomodulatory cells
pp 118-125
- By Bernd C. Kieseier, Wei Hu, Hans-Peter Hartung
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8 - Mutations in Schwann cell genes causing inherited neuropathies
pp 126-157
- By Michael E. Shy, John Kamholz, Jun Li
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9 - Guillain–Barré syndrome and the Schwann cell
pp 158-170
- By Richard A. C. Hughes
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10 - Chronic idiopathic demyelinating polyneuropathy and Schwann cells
pp 171-184
- By John D. Pollard
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References
pp 185-246
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Index
pp 247-249
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Plate section
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The Biology of Schwann Cells

Development, Differentiation and Immunomodulation

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Contents

Frontmatter
pp i-vi

Contents
pp vii-viii

Preface
pp ix-x

Contributors
pp xi-xiv

1 - Introduction to the Schwann cell
pp 1-12

2 - Early events in Schwann cell development
pp 13-36

3 - The molecular organisation of myelinating Schwann cells
pp 37-54

4 - The role of the extracellular matrix in Schwann cell development and myelination
pp 55-71

5 - The biology of perisynaptic (terminal) Schwann cells
pp 72-99

6 - Cytokine and chemokine interactions with Schwann cells: the neuroimmunology of Schwann cells
pp 100-117

7 - Schwann cells as immunomodulatory cells
pp 118-125

8 - Mutations in Schwann cell genes causing inherited neuropathies
pp 126-157

9 - Guillain–Barré syndrome and the Schwann cell
pp 158-170

10 - Chronic idiopathic demyelinating polyneuropathy and Schwann cells
pp 171-184

References
pp 185-246

Index
pp 247-249

Plate section

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The Biology of Schwann Cells

Development, Differentiation and Immunomodulation

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