Developmental Origins of Health and Disease

doi:10.1017/CBO9780511544699

This landmark publication provides the first definitive account of how and why subtle influences on the fetus and during early life can have such profound consequences for adult health and diseases. Although the epidemiological evidence for this link has long proved compelling, it is only much more recently that the scientific and physiological basis for this has begun to be studied in depth and fully understood. This compilation, written by many of the world's leading experts in this exciting field, summarizes these scientific and clinical advances. The link between early development and the onset of many chronic diseases such as coronary heart disease, diabetes and osteoporosis, also raises important public health issues. Another fascinating theme in the book concerns evolutionary developmental biology and how the 'evo-devo' debate can cast light on these concepts. Clinicians and scientists alike will all learn a lot about this exciting and emerging field.

'Researchers will find Developmental Origins of Health and Disease to be a well-referenced resource that documents the state of the art in the field and serves as a source of new ideas. Students of human and developmental biology and health practitioners should also keep the volume in close reach … The volume inspired me to think differently and to develop a new set of research questions to answer with my cohort data from a developing country …'

Source: Science

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Contents

Frontmatter
pp i-iv
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Contents
pp v-viii
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List of contributors
pp ix-xiv
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Preface
pp xv-xvi
- By Peter D. Gluckman, Professor of Paediatric and Perinatal Biology, Director of the Liggins Institute (for Medical Research) and Director of the National Research Centre for Growth and Development, University of Auckland, Mark A. Hanson, Director of the Developmental Origins of Health & Disease Research Division, University of Southampton Medical School
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1 - The developmental origins of health and disease: an overview
pp 1-5
- By Peter D. Gluckman, University of Auckland, Mark A. Hanson, University of Southampton
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2 - The ‘developmental origins’ hypothesis: epidemiology
pp 6-32
- By Keith Godfrey, University of Southampton
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3 - The conceptual basis for the developmental origins of health and disease
pp 33-50
- By Peter D. Gluckman, University of Auckland, Mark A. Hanson, University of Southampton
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4 - The periconceptional and embryonic period
pp 51-61
- By Tom P. Fleming, University of Southampton
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5 - Epigenetic mechanisms
pp 62-74
- By Emma Whitelaw, University of Sydney, David Garrick, Oxford University
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6 - A mitochondrial component of developmental programming
pp 75-81
- By Josie M. L. McConnell, King's College, London
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7 - Role of exposure to environmental chemicals in developmental origins of health and disease
pp 82-97
- By Jerrold J. Heindel, National Institute of Environmental Health Sciences, Cindy Lawler, National Institute of Environmental Health Sciences
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8 - Maternal nutrition and fetal growth and development
pp 98-129
- By Susan M. B. Morton, University of Auckland
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9 - Placental mechanisms and developmental origins of health and disease
pp 130-142
- By Leslie Myatt, University of Cincinnati, Victoria Roberts, University of Cincinnati
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10 - Control of fetal metabolism: relevance to developmental origins of health and disease
pp 143-158
- By Abigail L. Fowden, University of Cambridge, Janelle W. Ward, University of Cambridge, Alison J. Forhead, University of Cambridge
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11 - Lipid metabolism: relevance to developmental origins of health and disease
pp 159-177
- By Graham C. Burdge, University of Southampton, Philip C. Calder, University of Southampton
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12 - Prenatal hypoxia: relevance to developmental origins of health and disease
pp 178-190
- By Dino A. Giussani, University of Cambridge
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13 - The fetal hypothalamic–pituitary–adrenal axis: relevance to developmental origins of health and disease
pp 191-205
- By Deborah M. Sloboda, University of Western Australia, John P. Newnham, University of Western Australia, Timothy J. M. Moss, University of Western Australia, John R. G. Challis, University of Toronto
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14 - Perinatal influences on the endocrine and metabolic axes during childhood
pp 206-222
- By W. S. Cutfield, University of Auckland, C. A. Jefferies, University of Auckland, P. L. Hofman, University of Auckland
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15 - Patterns of growth: relevance to developmental origins of health and disease
pp 223-232
- By Johan G. Eriksson, National Public Health Institute, Finland
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16 - The developmental environment and the endocrine pancreas
pp 233-243
- By Brigitte Reusens, Université Catholique de Louvain, Luise Kalbe, Université Catholique de Louvain, Claude Remacle, Université Catholique de Louvain
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17 - The developmental environment and insulin resistance
pp 244-254
- By Noel H. Smith, University of Cambridge, Susan E. Ozanne, University of Cambridge
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18 - The developmental environment and the development of obesity
pp 255-264
- By Michael E. Symonds, University of Nottingham, David S. Gardner, University of Nottingham
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19 - The developmental environment and its role in the metabolic syndrome
pp 265-274
- By Christopher D. Byrne, University of Southampton, David I. W. Phillips, University of Southampton
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20 - Programming the cardiovascular system
pp 275-285
- By Kent L. Thornburg, Oregon Health and Science University
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21 - The role of vascular dysfunction in developmental origins of health and disease: evidence from human and animal studies
pp 286-299
- By Lucilla Poston, King's College, London, Christopher Torrens, University of Southampton, James A. Armitage, King's College, London, Mark A. Hanson, University of Southampton
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22 - The developmental environment and atherogenesis
pp 300-309
- By C. Napoli, University of Naples, O. Pignalosa, University of Naples, L. Rossi, University of Naples, C. Botti, University of Naples, C. Guarino, University of Naples, V. Sica, University of Naples, F. de Nigris, University of Naples
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23 - The developmental environment, renal function and disease
pp 310-322
- By Karen M. Moritz, Monash University, E. Marelyn Wintour, Monash University, Miodrag Dodic, Monash University
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24 - The developmental environment: effect on fluid and electrolyte homeostasis
pp 323-335
- By Mostafa A. El-Haddad, University of California, Los Angeles, Michael G. Ross, University of California, Los Angeles
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25 - The developmental environment: effects on lung structure and function
pp 336-348
- By Richard Harding, Monash University, Megan L. Cock, Monash University, Gert S. Maritz, University of the Western Cape
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26 - Developmental origins of asthma and related allergic disorders
pp 349-369
- By J. O. Warner, University of Southampton
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