Cerebrovascular Disease: 22nd Princeton Conference

doi:10.1017/CBO9780511544910

Prevention, diagnosis and treatment are the watchwords in stroke research, for basic neuroscientists and clinicians alike. This 2002 book, from the 22nd Princeton Conference on Cerebrovascular Disease, contains contributions from outstanding investigators on numerous topics in stroke research. The contents cover the status and future directions of stroke pathophysiology, diagnosis and treatment, with special emphasis on the molecular and cellular mechanisms of ischaemic cell death and repair, and clinical issues including imaging, risk factors and therapeutic strategies in stroke. Available in both print and online formats, this survey of the basic and clinical science of stroke is an essential resource for all involved in advancing knowledge of cerebrovascular disease.

"Anyone with a basic understanding of stroke, who wants or needs to be brought reasonably up to date (the conference was held three years ago) should read this book. The subject matter is topical, and exciting breakthroughs are explained. ...this book fills an important gap." Journal of Neurosurgery, May 2003

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Contents

Frontmatter
pp i-iv
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Contents
pp v-ix
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List of contributors
pp x-xviii
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Preface
pp xix-xx
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Acknowledgments
pp xxi-xxii
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Part I - Special lectures
pp 1-2
- By Richard J. Traystman
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1 - Zinc toxicity in the ischemic brain
pp 3-8
- By Dennis W. Choi, Center for the Study of Nervous System Injury and Department of Neurology, Washington University School of Medicine, St. Louis, MO
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2 - Central nervous system ischemia: diversity among the caspases
pp 9-20
- By Nikolaus Plesnila, Stroke and Neurovascular Regulation Laboratory, Massachusetts General Hospital, Boston, MA, Michael A. Moskowitz, Stroke and Neurovascular Regulation Laboratory, Massachusetts General Hospital, Boston, MA
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Part II - Oxidative stress
pp 21-22
- By Raymond A. Swanson, Bo K. Siesjö
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3 - Peroxynitrite and injury to the vasculature and central nervous system in stroke and neurodegeneration
pp 23-46
- By Joseph S. Beckman, Departments of Anesthesiology, Biochemistry, and Neurobiology, University of Alabama at Birmingham, Birmingham, AL, John Crow, Departments of Anesthesiology and Pharmacology, University of Alabama at Birmingham, Birmingham, AL, Alvaro G. Estévez, Departments of Pharmacology and Physiology, University of Alabama at Birmingham, Birmingham, AL
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4 - Interaction between inducible nitric oxide and cyclooxygenase-2 in ischemic brain injury
pp 47-57
- By Costantino Iadecola, Center for Clinical and Molecular Neurobiology, University of Minnesota, Minneapolis, MN
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5 - Mechanisms of ischemic tolerance
pp 58-71
- By Valina L. Dawson, Departments of Neurology, Neuroscience and Physiology, Johns Hopkins University School of Medicine, Baltimore, MD, Ted M. Dawson, Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD
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6 - Clinically tolerated NMDA receptor antagonists and newly cloned NMDA receptor subunits that mimic them
pp 72-78
- By Stuart A. Lipton, Center for Neuroscience and Aging, The Burnham Institute, La Jolla, CA
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Part III - Apoptosis
pp 79-80
- By Robert M. Sapolsky, Chung Y. Hsu
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7 - Cell death programs in neural development and disease
pp 81-86
- By Sabina Sperandio, Buck Institute for Age Research, Novato, CA, Ian deBelle, Burnham Institute, La Jolla, CA, Susana Castro-Obregon, Buck Institute for Age Research, Novato, CA, Gabriel del Rio, Buck Institute for Age Research, Novato, CA, Dale E. Bredesen, Buck Institute for Age Research, Novato, CA; Department of Neurology, University of California, San Francisco, San Francisco, CA
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8 - Apoptotic gene expression in brain ischemia and ischemic tolerance
pp 87-94
- By Roger P. Simon, R. S. Dow Center for Neurobiology, Legacy Research, Portland, OR
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9 - Cellular mechanisms of white matter ischemia: what can we learn from culture models?
pp 95-110
- By Suzanne Underhill, Department of Neurology, Washington University School of Medicine, St. Louis, MO, Selva Baltan Tekkök, Department of Neurology, Washington University School of Medicine, St. Louis, MO, M. Josh Hasbani, Department of Neurology, Washington University School of Medicine, St. Louis, MO, Mark P. Goldberg, Department of Neurology, Washington University School of Medicine, St. Louis, MO
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Part IV - Hot topics
pp 111-112
- By Rona G. Giffard, Myron D. Ginsberg
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10 - Astrocytes in ischemic stroke
pp 113-124
- By Jane H.-C. Lin, Department of Pathology, New York Medical College, Valhalla, New York, Maiken Nedergaard, Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York
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11 - Aquaporin-4 water channels and brain edema
pp 125-134
- By Geoffrey T. Manley, Department of Neurological Surgery, University of California, San Francisco, CA, Miki Fujimura, Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, Tonghui Ma, Departments of Medicine and Physiology, Cardiovascular Research Institute, University of California, San Francisco, CA, Nobuo Noshita, Ferda Filiz, Departments of Medicine and Physiology, Cardiovascular Research Institute, University of California, San Francisco, CA, Andrew W. Bollen, Department of Pathology, University of California, San Francisco, CA, Pak H. Chan, Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, Alan S. Verkman, Departments of Medicine and Physiology, Cardiovascular Research Institute, University of California, San Francisco, CA
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12 - Neuroprotection with tetracyclines in brain ischemia models
pp 135-141
- By Jari Koistinaho, A.I. Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland
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13 - Spreading depression: a teleological means for self-protection from brain ischemia
pp 142-158
- By Richard P. Kraig, Departments of Neurology and Neurobiology, Pharmacology & Physiology, University of Chicago, Chicago, IL, Phillip E. Kunkler, Department of Neurology, University of Chicago, Chicago, IL
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Part V - Hemorrhage, edema and secondary injury
pp 159-160
- By Philip R. Weinstein, Julian T. Hoff
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14 - The role of matrix metalloproteinases and urokinase in blood–brain barrier damage with thrombolysis
pp 161-171
- By Gary A. Rosenberg, Departments of Neurology, Neuroscience and Cell Biology and Physiology, University of New Mexico, Albuquerque, NM, Susan Alexander, Department of Neurology, University of New Mexico, Albuquerque, NM, Edward Y. Estrada, Department of Neurology, University of New Mexico, Albuquerque, NM, Mark Grostette, Department of Neurology, University of New Mexico, Albuquerque, NM
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15 - Does brain nitric oxide generation influence tissue oxygenation after severe human subarachnoid hemorrhage?
pp 172-180
- By Ahmad Khaldi, Division of Neurosurgery, Medical College of Virginia, VCU, Richmond, VA, Alois Zauner, Division of Neurosurgery, Medical College of Virginia, VCU, Richmond, VA, Michael Reinert, Division of Neurosurgery, Medical College of Virginia, VCU, Richmond, VA, Itaf Fakhry, Department of Internal Medicine–Clinical Pharmacology, Medical College of Virginia, VCU, Richmond, VA, Domenic A. Sica, Department of Internal Medicine–Clinical Pharmacology, Medical College of Virginia, VCU, Richmond, VA, Ross Bullock, Division of Neurosurgery, Medical College of Virginia, VCU, Richmond, VA
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16 - Tissue plasminogen activator and hemorrhagic brain injury
pp 181-191
- By Minoru Asahi, Neuroprotection Research Laboratory, Departments of Neurology and Radiology, Massachusetts General Hospital, and Program in Neuroscience, Harvard Medical School, Boston, MA, Rick M. Dijkhuizen, Neuroprotection Research Laboratory, Departments of Neurology and Radiology, Massachusetts General Hospital, and Program in Neuroscience, Harvard Medical School, Boston, MA; NMR Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, Xiaoying Wang, Neuroprotection Research Laboratory, Departments of Neurology and Radiology, Massachusetts General Hospital, and Program in Neuroscience, Harvard Medical School, Boston, MA, Bruce R. Rosen, NMR Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, Eng H. Lo, Neuroprotection Research Laboratory, Departments of Neurology and Radiology, Massachusetts General Hospital, and Program in Neuroscience, Harvard Medical School, Boston, MA
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17 - Dynamics of infarct evolution after permanent and transient focal brain ischemia in mice
pp 192-210
- By Konstantin-Alexander Hossmann, Max-Planck-Institute for Neurological Research, Department of Experimental Neurology, Cologne, Germany, Ryuji Hata, Max-Planck-Institute for Neurological Research, Department of Experimental Neurology, Cologne, Germany, Takayuki Hara, Max-Planck-Institute for Neurological Research, Department of Experimental Neurology, Cologne, Germany
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Part VI - Inflammation
pp 211-212
- By Midori A. Yenari, Gregory J. Del Zoppo
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18 - Inflammation and stroke: benefits or harm?
pp 213-225
- By Giora Z. Feuerstein, DuPont Pharmaceuticals Company, Wilmington, DE, Elaine E. Peters, DuPont Pharmaceuticals Company, Wilmington, DE, Xinkang Wang, DuPont Pharmaceuticals Company, Wilmington, DE
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19 - TNF-α and ceramide are involved in the mediation of neuronal tolerance to brain ischemia
pp 226-236
- By Irene Ginis, Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, Jie Liu, Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, Maria Spatz, Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, John M. Hallenbeck, Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD
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22nd Princeton Conference

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