Drugs for the Treatment of Respiratory Diseases

doi:10.1017/CBO9780511545696

Respiratory diseases affect millions of people each year and represent a major health burden around the world. This timely reference surveys and evaluates the drug treatments available for the main categories of lung diseases including asthma, tuberculosis, chronic obstructive pulmonary disease, lung cancer, and respiratory infections. The recent re-emergence of tuberculosis and the increase in asthma in certain populations underlines the importance of finding effective new treatments for these diseases. This publication, a comprehensive reference, is one of the first to survey current and novel drug treatments for this group of diseases. It is certain to establish itself as an essential source of reference for respiratory physicians, clinicians and clinical pharmacologists.

‘… this book will become an essential source of reference for respiratory clinicians and clinical pharmacologists … clearly written and produced and usually well illustrated.’

Source: Pharmaceutical Journal

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Contents

Frontmatter
pp i-iv
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Contents
pp v-vi
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List of contributors
pp vii-x
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Preface
pp xi-xii
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Part I - Asthma and COPD
pp 1-2
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1 - Pathology of asthma and COPD: inflammation and structure
pp 3-31
- By Peter K. Jeffery, Imperial College at the Royal Brompton Hospital, London, UK
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2 - Glucocorticosteroids
pp 32-55
- By Peter J. Barnes, Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
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3 - β2-adrenoceptor agonists
pp 56-104
- By Domenico Spina, The Sackler Institute of Pulmonary Pharmacology, Department of Respiratory Medicine and Allergy, GKT School of Medicine, King's College London, UK., Clive P. Page, Division of Pharmacology and Therapeutics, GKT School of Biomedical Sciences, Guy's Campus, London, UK, Brian J. O'Connor, The Sackler Institute of Pulmonary Pharmacology, Department of Respiratory Medicine and Allergy, GKT School of Medicine, King's College London, UK.
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4 - Anticholinergic bronchodilators
pp 105-118
- By Jeremy M. Segal, Departments of Medicine and Molecular Biochemistry, Stritch School of Medicine, Loyola University of Chicago, IL, USA, Nicholas J. Gross, Hines Veterans Affairs Hospital, Hines, IL, USA
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5 - Antiallergic drugs
pp 119-123
- By Masakazu Ichinose, Department of Respiratory and Infectious Diseases, Tohoku University School of Medicine, Sendai, Japan
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6 - Drugs affecting the synthesis and action of leukotrienes
pp 124-135
- By Paul M. O'Byrne, Firestone Institute for Respiratory Health, St Joseph's Healthcare, Hamilton, Ontario, Canada
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7 - Theophylline and selective phosphodiesterase inhibitors in the treatment of respiratory disease
pp 136-171
- By Neil A. Jones, The Sackler Institute of Pulmonary Pharmacology and Therapeutics Division, GKT School of Biomedical Sciences, Hodgkin Building, Guy's Campus, London, UK, Domenico Spina, Department of Respiratory Medicine and Allergy, GKT School of Medicine, King's College London, UK, Clive P. Page, The Sackler Institute of Pulmonary Pharmacology, Pharmacology and Therapeutics Division, GKT School of Biomedical Sciences, Hodgkin Building, Guy's Campus, London, UK
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8 - Potential therapeutic effects of potassium channel openers in respiratory diseases
pp 172-183
- By Ahmed Z. El-Hashim, Department of Applied Therapeutics, Faculty of Pharmacy, Kuwait University
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9 - Tachykinin and kinin antagonists
pp 184-194
- By Pierangelo Geppetti, Department of Experimental and Clinical Medicine, Pharmacology Unit, University of Ferrara, Ferrara, Italy
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10 - Drugs affecting IgE (Synthesis inhibitors and monoclonal antibodies)
pp 195-217
- By Lawrence G. Garland, Alan G. Lamont, Acambis PLC, Cambridge, UK
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11 - Drugs targeting cell signalling
pp 218-244
- By Brydon L. Bennett, Yoshitaka Satoh, Alan J. Lewis, Signal Research Division, Celgene Corporation, San Diego, CA, USA
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Part II - Diffuse parenchymal lung disease
pp 245-246
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12 - Current approaches to the treatment of parenchymal lung diseases
pp 247-335
- By Joseph P. Lynch III, Michael Keane, Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI, USA
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13 - Drug treatments of the future in fibrotic lung disease
pp 336-360
- By Athol U. Wells, Interstitial Lung Disease Unit, Departments of Radiology, Pathology and Physiology, Royal Brompton Hospital, Sydney Street, London, UK
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Part III - Infection
pp 361-362
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14 - Current and future management of pneumonia
pp 363-402
- By Mario Cazzola, Department of Respiratory Medicine, Division of Pneumology and Allergology, A. Cardarelli Hospital, Naples, Italy, Maria Gabriella Matera, Institute of Pharmacology and Toxicology, Medical School, Second Neapolitan University, Naples, Italy
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15 - Current treatment of chronic bronchial suppuration
pp 403-427
- By Robert Wilson, Royal Brompton Hospital, Sydney Street, London SW3 6N, UK.
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16 - Current and future treatment of cystic fibrosis
pp 428-450
- By R. G. Gary Ruiz, Hilary H. Wyatt, John F. Price, Department of Child Health, King's College Hospital, Denmark Hill, London, UK
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Part IV - Pulmonary vascular diseases
pp 451-452
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17 - Pathophysiology of pulmonary vascular disease
pp 453-474
- By Sanjay Mehta, David G. McCormack, A. C. Burton Vascular Research Laboratory, Division of Respirology, London Health Sciences Centre, Departments of Medicine, Pharmacology and Toxicology, University of Western Ontario, London, Ontario, Canada
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18 - Current treatment of pulmonary vascular diseases
pp 475-503
- By Tarek Saba, Andrew Peacock, Scottish Pulmonary Vascular Unit, Western Infirmary, Glasgow, UK
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19 - Future treatment of pulmonary vascular diseases
pp 504-516
- By Norbert F. Voelkel, Mark W. Geraci, Steven Abman, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
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Part V - Lung cancer
pp 517-518
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20 - Molecular pathology of lung cancer
pp 519-534
- By Ignacio I. Wistuba, Department of Pathology, Pontificia Universidad Catolica de Chile, Santiago, Chile, Adi F. Gazdar, Hamon Center for Therapeutic Oncology Research and Department of Pathology, University of Texas Southwestern Medical Center, Dallas, USA
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21 - Small cell lung cancer
pp 535-550
- By Desmond N. Carney, Department of Medical Oncology, Mater Hospital, Dublin, Ireland
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