Bacterial Protein Toxins: Role in the Interference with Cell Growth Regulation

doi:10.1017/CBO9780511546280

Bacterial toxins that act inside cells interact very specifically with key components of the cell and some even manipulate the cell in subtle ways for their own purposes. These potent toxins, described in this 2005 book, will be of interest to both microbiologists and cell biologists. Some of these toxins are conventional multidomain toxins that are self-programmed to enter cells. Others are delivered by type III mechanisms, often as a package of potent molecules. The molecular targets for all these toxins mediate signal transduction and the cell cycle to regulate the crucial processes of cell growth, cell division and differentiation. Thus these potent toxins are not only responsible for disease, but also provide a powerful set of tools with which to interrogate the biology of the cell. In addition such toxins may act directly to promote carcinogenesis and hence their study is also of interest in a wider context.

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Contents

Frontmatter
pp i-vi
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Contents
pp vii-viii
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List of Contributors
pp ix-xii
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Preface
pp xiii-xiv
- By Alistair J Lax, Professor of Cellular Microbiology, King's College London
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1 - Toxins and the interaction between bacterium and host
pp 1-6
- By Alistair J Lax, Department of Microbiology, Dental Institute, King's College London
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2 - The mitogenic Pasteurella multocida toxin and cellular signalling
pp 7-32
- By Gillian D Pullinger, Institute for Animal Health
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3 - Rho-activating toxins and growth regulation
pp 33-52
- By Gudula Schmidt, Institut für Experimentelle und Klinische Pharmakologie und Toxikologie der Albert-Ludwigs-Universität Freiburg, Klaus Aktories, Institut für Experimentelle und Klinische Pharmakologie und Toxikologie der Albert-Ludwigs-Universität Freiburg
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4 - Cytolethal distending toxins: A paradigm for bacterial cyclostatins
pp 53-80
- By Bernard Ducommun, LBCMCP-CNRS UMR5088, Université Paul Sabatier, Institut d'Exploration Fonctionnelle des Génomes (IFR109), Jean De Rycke, UR 918 INRA de Pathologie Infectieuse et Immunologie
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5 - Bartonella signaling and endothelial cell proliferation
pp 81-116
- By Garret Ihler, Department of Medical Biochemistry and Genetics, Texas A&M College of Medicine, Anita Verma, Laboratory of Respiratory and Special Pathogens, DBPAP/CBER, Food and Drug Administration, Javier Arevalo, Proctor and Gamble America Latina
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6 - Type III–delivered toxins that target signalling pathways
pp 117-146
- By Luís J Mota, Division of Molecular Microbiology, Biozentrum, Universität Basel, Guy R Cornelis, Division of Molecular Microbiology, Biozentrum, Universität Basel
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7 - Bacterial toxins and bone remodelling
pp 147-168
- By Neil W A McGowan, Department of Craniofacial Development, Dental Institute, King's College London, Dympna Harmey, The Burnham Institute, Fraser P Coxon, Department of Medicine and Therapeutics, University of Aberdeen, Gudrun Stenbeck, Bone and Mineral Centre, University College London, Michael J Rogers, Department of Medicine and Therapeutics, University of Aberdeen, Agamemnon E Grigoriadis, Department of Craniofacial Development, Dental Institude, King's College London
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8 - Helicobacter pylori mechanisms for inducing epithelial cell proliferation
pp 169-198
- By Michael Naumann, Institute of Experimental Internal Medicine, Medical Faculty, Otto-van-Guericke-University, Jean E Crabtree, Molecular Medicine Unit, St James's University Hospital
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9 - Bacteria and cancer
pp 199-226
- By Christine P J Caygill, University Department of Surgery, Royal Free Hospital, Michael J Hill, European Cancer Prevention Organization, Nutrition Research Centre, South Bank University
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10 - What is there still to learn about bacterial toxins?
pp 227-230
- By Alistair J Lax, Department of Microbiology, Dental Institute, King's College London
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Index
pp 231-239
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Plate section
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Bacterial Protein Toxins

Role in the Interference with Cell Growth Regulation

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Contents

Frontmatter
pp i-vi

Contents
pp vii-viii

List of Contributors
pp ix-xii

Preface
pp xiii-xiv

1 - Toxins and the interaction between bacterium and host
pp 1-6

2 - The mitogenic Pasteurella multocida toxin and cellular signalling
pp 7-32

3 - Rho-activating toxins and growth regulation
pp 33-52

4 - Cytolethal distending toxins: A paradigm for bacterial cyclostatins
pp 53-80

5 - Bartonella signaling and endothelial cell proliferation
pp 81-116

6 - Type III–delivered toxins that target signalling pathways
pp 117-146

7 - Bacterial toxins and bone remodelling
pp 147-168

8 - Helicobacter pylori mechanisms for inducing epithelial cell proliferation
pp 169-198

9 - Bacteria and cancer
pp 199-226

10 - What is there still to learn about bacterial toxins?
pp 227-230

Index
pp 231-239

Plate section

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Bacterial Protein Toxins

Role in the Interference with Cell Growth Regulation

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