Neurodevelopmental Mechanisms in Psychopathology

doi:10.1017/CBO9780511546365

This volume represents a burgeoning perspective on the origins of psychopathology, one that focuses on the development of the human central nervous system. The contemporary neurodevelopmental perspective assumes that mental disorders result from etiologic factors that alter the normal course of brain development. Defined here in its broadest sense, neurodevelopment is a process that begins at conception and extends throughout the life span. We now know that it is a complex process, and that its course can be altered by a host of factors, ranging from inherited genetic liabilities to psychosocial stressors. This book features the very best thinking in the converging fields of developmental neuroscience and developmental psychopathology. The developmental window represented is broad, extending from the prenatal period through adulthood, and the authors cover a broad range of etiologic factors and a spectrum of clinical disorders. Moreover, the contributors did not hesitate to use the opportunity to hypothesize about underlying mechanisms and to speculate on research directions.

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Contents

Frontmatter
pp i-iv
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Contents
pp v-vi
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List of Contributors
pp vii-viii
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Preface
pp ix-xii
- By Dante Cicchetti, Professor of Psychology, Psychiatry, and Pediatrics and Director of Mt. Hope Family Center, University of Rochester in New York, Elaine F. Walker, Professor of Psychology and Neuroscience, Emory University in Atlanta, Georgia
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NEURODEVELOPMENTAL MECHANISMS IN PSYCHOPATHOLOGY
pp xiii-xiv
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Part One - Basic Mechanisms in Prenatal, Perinatal, and Postnatal Neurodevelopmental Processes and Their Associations with High-Risk Conditions and Adult Mental Disorders
pp 1-2
- By Dante Cicchetti, Professor of Psychology, Psychiatry, and Pediatrics and Director of Mt. Hope Family Center, University of Rochester in New York, Elaine F. Walker, Professor of Psychology and Neuroscience, Emory University in Atlanta, Georgia
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1 - Principles of Neurobehavioral Teratology
pp 3-33
- By Linda C. Mayes, Yale Child Study Center, Yale University, Anna Ward, Yale Child Study, Center Yale University
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2 - The Neurodevelopmental Consequences of Very Preterm Birth: Brain Plasticity and Its Limits
pp 34-61
- By Chiara Nosarti, Institute of Psychiatry, Kings College London, Larry Rifkin, Institute of Psychiatry, Kings College London, Robin M. Murray, Institute of Psychiatry, Kings College London
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3 - Neurodevelopment During Adolescence
pp 62-83
- By Linda Patia Spear, Center for Developmental Psychobiology, Binghamton University
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5 - Prenatal Risk Factors for Schizophrenia
pp 84-110
- By Alan S. Brown, Department of Psychiatry, Columbia University, Ezra S. Susser, Department of Psychiatry, Columbia University
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5 - Obstetric Complications and Neurodevelopmental Mechanisms in Schizophrenia
pp 111-137
- By Isabelle M. Rosso, Department of Psychiatry, Harvard Medical School, Tyrone D. Cannon, Department of Psychology, University of California, Los Angeles
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6 - Maternal Influences on Prenatal Neural Development Contributing to Schizophrenia
pp 138-152
- By Jason Schiffman, Social Science Research Institute, University of Southern California, Sarnoff A. Mednick, Social Science Research Institute, University of Southern California, Ricardo Machón, Social Science Research Institute, University of Southern California, Matti Huttunen, Social Science Research Institute, University of Southern California, Kay Thomas, Social Science Research Institute, University of Southern California, Seymour Levine, Department of Psychology, University of California-Davis
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Part Two - Animal Models of Neurodevelopment and Psychopathology
pp 153-154
- By Dante Cicchetti, Professor of Psychology, Psychiatry, and Pediatrics and Director of Mt. Hope Family Center, University of Rochester in New York, Elaine F. Walker, Professor of Psychology and Neuroscience, Emory University in Atlanta, Georgia
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7 - On the Relevance of Prenatal Stress to Developmental Psychopathology: A Primate Model
pp 155-186
- By Mary L. Schneider, Department of Kinesiology and Psychology, University of Wisconsin – Madison, Colleen F. Moore, Department of Psychology, University of Wisconsin – Madison, Gary W. Kraemer, Department of Kinesiology, University of Wisconsin – Madison
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8 - Nonhuman Primate Models of Developmental Psychopathology: Problems and Prospects
pp 187-214
- By Dario Maestripieri, Committee on Human Development, University of Chicago, Kim Wallen, Department of Psychology, Emory University
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9 - Early Orbitofrontal-Limbic Dysfunction and Autism
pp 215-236
- By Jocelyne Bachevalier, Department of Neurobiology and Anatomy, University of Texas Health Science Center, Katherine A. Loveland, Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center
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Part Three - Models of the Nature of Genetic and Environmental Influences on the Developmental Course of Psychopathology
pp 237-238
- By Dante Cicchetti, Professor of Psychology, Psychiatry, and Pediatrics and Director of Mt. Hope Family Center, University of Rochester in New York, Elaine F. Walker, Professor of Psychology and Neuroscience, Emory University in Atlanta, Georgia
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10 - Genetic Structure of Neurodevelopmental Traits: Implications for the Development (and Definition of) Psychopathology
pp 239-256
- By Richard D. Todd, Division of Child Psychiatry, Washington University School of Medicine, John N. Constantino, Department of Psychiatry, Washington University School of Medicine
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11 - Prospects and Problems in the Search for Genetic Influences on Neurodevelopment and Psychopathology: Application to Childhood Disruptive Disorders
pp 257-292
- By Irwin D. Waldman, Department of Psychology, Emory University
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12 - Developmental Psychoneuroimmunology: The Role of Cytokine Network Activation in the Epigenesis of Developmental Psychopathology
pp 293-323
- By Douglas A. Granger, Department of Biobehavioral Health, Pennsylvania State of University, Nancy A. Dreschel, Department of Biobehavioral Health, Pennsylvania State of University, Elizabeth A. Shirtcliff, Department of Biobehavioral Health, Pennsylvania State of University
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13 - The Hypothalamic–Pituitary–Adrenal System (HPA) and the Development of Aggressive, Antisocial, and Substance Abuse Disorders
pp 324-344
- By Keith McBurnett, Department of Psychiatry, University of Chicago, Jean King, Department of Psychiatry, University of Massachusetts, Angela Scarpa, Department of Psychology, Virginia Polytechnic Institute
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14 - Neuroendocrine Functioning in Maltreated Children
pp 345-365
- By Dante Cicchetti, Mt. Hope Family Center, University of Rochester
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15 - Toward Unraveling the Premorbid Neurodevelopmental Risk for Schizophrenia
pp 366-383
- By Matcheri S. Keshavan, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine
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16 - Interactions of the Dopamine, Serotonin, and GABA Systems During Childhood and Adolescence: Influence of Stress on the Vulnerability for Psychopathology
pp 384-402
- By Francine M. Benes, Department of Psychiatry, Columbia University
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Part Four - The Neurodevelopmental Course of Illustrative High-Risk Conditions and Mental Disorders
pp 403-404
- By Dante Cicchetti, Professor of Psychology, Psychiatry, and Pediatrics and Director of Mt. Hope Family, Center University of Rochester in New York, Elaine F. Walker, Professor of Psychology and Neuroscience, Emory University in Atlanta, Georgia
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17 - Neurobiology of Personality Disorders: Implications for a Neurodevelopmental Model
pp 405-427
- By Larry J. Siever, Department of Psychiatry, Mount Sinai School of Medicine, Harold W. Koenigsberg, Department of Psychiatry, Mount Sinai School of Medicine, Deidre Reynolds, Department of Psychiatry, Mount Sinai School of Medicine
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18 - Genesis and Epigenesis of Psychopathology in Children with Depressed Mothers: Toward an Integrative Biopsychosocial Perspective
pp 428-460
- By Sherryl H. Goodman, Department of Psychology, Emory University
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19 - The Neurobiology of Child and Adolescent Depression: Current Knowledge and Future Directions
pp 461-490
- By Joan Kaufman, Department of Psychiatry, Yale University School of Medicine, Dennis Charney, Mood and Anxiety Disorders Research Program, National Institute of Mental Health
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20 - Psychosocial Stressors as Predisposing Factors to Affective Illness and PTSD: Potential Neurobiological Mechanisms and Theoretical Implications
pp 491-525
- By Robert M. Post, Biological Psychiatry Branch, National Institute of Mental Health, Gabriele S. Leverich, Biological Psychiatry Branch, National Institute of Mental Health, Susan R. B. Weiss, Biological Psychiatry Branch, National Institute of Mental Health, Li-Xin Zhang, Biological Psychiatry Branch, National Institute of Mental Health, Guoqiang Xing, Department of Psychiatry Uniformed Services, National Institute of Mental Health, He Li, Biological Psychiatry Branch, National Institute of Mental Health, Mark Smith, Experimental Station, DuPont, Pharmaceutical National Institute of Mental Health
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21 - Neurohormonal Aspects of the Development of Psychotic Disorders
pp 526-544
- By Elaine F. Walker, Professor of Psychology and Neuroscience, Emory University in Atlanta, Georgia, Deborah Walder, Department of Psychology, Emory University
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