Drug Resistance in Cancer: Mechanisms and Models

James H. Goldie; Andrew J. Coldman

doi:10.1017/CBO9780511666544

Drug resistance in cancer, whereby a proportion of cancer cells evades chemotherapy, poses a profound and continuing challenge for the effective treatment of cancer. The principles underlying the biological mechanisms behind this phenomenon are clearly understood and explained in this volume. However, a deeper understanding of drug resistance requires a quantitative appreciation of the dynamic forces that shape tumour growth, including spontaneous mutation and selection processes. The authors seek to explain and to simplify these complex mechanisms, and to place them in a clinical context. Clearly explained mathematical models are used to illustrate the biological principles and provide an insight into tumour development and the effectiveness and limitations of drug treatment. It is suitable for those with a non-mathematical background and aims to enhance the effectiveness of cancer therapy.

‘However, this volume provides a very good overview of the drug resistance field with special emphasis on mathematical models and can be recommended to everyone interested in the field. Even those who see math as an alien subject will find this book useful, since the mathematical portions of the text have been kept as straightforward as possible. The book is a good source of references and suggestions for further reading and should interest a wide readership including clinicians, molecular biologists, and researchers interested in tumor growth, tumor killing and mutation models.’

V. Spataro Source: Annals of Oncology

‘… required reading for all trainees in oncology.’

Paul P. Carbone Source: Oncology

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Drug Resistance in Cancer

Mechanisms and Models

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Contents

Frontmatter
pp i-iv

Contents
pp v-v

Terms used in the book
pp vi-vi

preface
pp vii-viii

1 - The biological basis of cancer and the problem of drug resistance
pp 1-23

2 - Tumour growth, stem cells and experimental chemotherapy
pp 24-58

3 - Molecular aspects of drug resistance
pp 59-89

4 - Quantitative descriptions of the origins of drug resistance
pp 90-121

5 - Development and exploration of the random mutation model for drug resistance
pp 122-147

6 - Extensions of the random mutation model for drug resistance
pp 148-194

7 - Clinical predictions of the random mutation model
pp 195-218

8 - Directed versus random mutation and the problem of intrinsic resistance
pp 219-237

9 - Some final thoughts on the problem of drug resistance
pp 238-244

Index
pp 245-247

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Mechanisms and Models

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