The Biology of Human Ageing

A. H. Bittles; K. J. Collins

doi:10.1017/CBO9780511753350

The processes that control senescence have been the subject of more then a century of serious biological research. Two institutions closely involved in this programme, the Society for the Study of Human Biology and the British Society for Research in Ageing, held a joint symposium in 1984 to consider human ageing and longevity from an interdisciplinary point of view. The resulting book has four main sections: the evolution and genetics of ageing, biological age assessment, demographic and social aspects, and the nutritional and physiological aspects of ageing and longevity. The fundamental nature of the subject will generate interest across a wide range of biological and medical disciplines.

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Contents

Frontmatter
pp i-iv
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Contents
pp v-vi
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Preface
pp vii-viii
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Ageing as a consequence of natural selection
pp 1-16
- By T. B. L. Kirkwood, National Institute for Medical Research, The Ridgeway, Mill Hill, London, U.K., R. Holliday, National Institute for Medical Research, The Ridgeway, Mill Hill, London, U.K.
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Genetic information in ageing cells
pp 17-32
- By S. P. Modak, Department of Zoology, University of Poona, Pune, India;, D. D. Deobagkar, Department of Zoology, University of Poona, Pune, India;, G. Leuba-Gfeller, Institute of Anatomy-CHUV, University of Lausanne, Lausanne, Switzerland;, C. Gonet, Institute of Anatomy-CHUV, University of Lausanne, Lausanne, Switzerland;, S. Basu-Modak, Department of Zoology, University of Poona, Pune, India;
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Insects as models for testing theories of ageing
pp 33-48
- By M. J. Lamb, Zoology Department, Birkbeck College, University of London, London, U.K.
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Human cell culture systems in the study of ageing
pp 49-66
- By A. H. Bittles, Department of Anatomy and Human Biology, KingTs College, University of London, London, U.K., Y. Sambuy, Istituto di Anatomia ed Istologia Patologica II, Universita Degli Studi di Roma, Rome, Italy
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Estimation of biological maturity in the older child
pp 67-80
- By M. A. Preece, Department of Growth and Development Institute of Child Health, London, L. A. Cox, Department of Growth and Development Institute of Child Health, London
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Biological age assessment in adulthood
pp 81-94
- By G. A. Borkan, Normative Aging Study, Veterans Administration Outpatient Clinic Boston, Massachusetts, United States of America
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Skeletal age and palaeodemography
pp 95-118
- By T. I. Molleson, Department of Palaeontology, British Museum (Natural History), London, U.K.
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Cell death and the loss of structural units of organs
pp 119-132
- By D. Bellamy, Department of Zoology, University College, Cardiff, U.K.
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The prospects for mortality decline and consequent changes in age structure of the population
pp 133-154
- By B. Benjamin, Centre for Research in Insurance and Investment, The City University, London, U.K.
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Where do old people come from? An evaluation of American population projections
pp 155-180
- By J. S. MacDonald, King's College, University of London, London, U.K.
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Age structure of Soviet population in the Caucasus: facts and myths
pp 181-200
- By Zh. A. Medvedev, Genetics Division, National Institute for Medical Research Mill Hill, London, U.K.
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The health of an ageing population
pp 201-214
- By J. Grimley Evans, Division of Geriatric Medicine, Nuffield Department of Clinical Medicine, The Radcliffe Infirmary, Oxford, U.K.
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Can we tell our age from our biochemistry?
pp 215-222
- By A. Bailey, BUPA Medical Centre, Medical Information Technology, Intercity House, Victoria Street, Bristol, U.K.
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Dietary manipulation of ageing: an animal model
pp 223-242
- By B. J. Merry, The Wolfson Institute, The University of Hull, Hull, U.K.
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Customary physical activity in the elderly
pp 243-260
- By J. M. Patrick, Department of Physiology & Pharmacology, University Medical School Queen's Medical Centre, Clifton Boulevard, Nottingham, U.K.
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Effects of ageing on human homeostasis
pp 261-275
- By K. J. Collins, Department of Geriatric Medicine, University College School of Medicine, St. Pancras Hospital, London, U.K., A. N. Exton-Smith, Department of Geriatric Medicine, University College School of Medicine, St. Pancras Hospital, London, U.K.
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Index
pp 276-280
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The Biology of Human Ageing

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Contents

Frontmatter
pp i-iv

Contents
pp v-vi

Preface
pp vii-viii

Ageing as a consequence of natural selection
pp 1-16

Genetic information in ageing cells
pp 17-32

Insects as models for testing theories of ageing
pp 33-48

Human cell culture systems in the study of ageing
pp 49-66

Estimation of biological maturity in the older child
pp 67-80

Biological age assessment in adulthood
pp 81-94

Skeletal age and palaeodemography
pp 95-118

Cell death and the loss of structural units of organs
pp 119-132

The prospects for mortality decline and consequent changes in age structure of the population
pp 133-154

Where do old people come from? An evaluation of American population projections
pp 155-180

Age structure of Soviet population in the Caucasus: facts and myths
pp 181-200

The health of an ageing population
pp 201-214

Can we tell our age from our biochemistry?
pp 215-222

Dietary manipulation of ageing: an animal model
pp 223-242

Customary physical activity in the elderly
pp 243-260

Effects of ageing on human homeostasis
pp 261-275

Index
pp 276-280

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