Systems Biology of Cancer

doi:10.1017/CBO9780511979811

With over two hundred types of cancer diagnosed to date, researchers the world over have been forced to rapidly update their understanding of the biology of cancer. In fact, only the study of the basic cellular processes, and how these are altered in cancer cells, can ultimately provide a background for rational therapies. Bringing together the state-of-the-art contributions of international experts, Systems Biology of Cancer proposes an ultimate research goal for the whole scientific community: exploiting systems biology to generate in-depth knowledge based on blueprints that are unique to each type of cancer. Readers are provided with a realistic view of what is known and what is yet to be uncovered on the aberrations in the fundamental biological processes, deregulation of major signaling networks, alterations in major cancers and the strategies for using the scientific knowledge for effective diagnosis, prognosis and drug discovery to improve public health.

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Systems Biology of Cancer - Half title page
pp i-ii
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Systems Biology of Cancer - Title page
pp iii-iii
- By Sam Thiagalingam
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Copyright page
pp iv-iv
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Dedication
pp v-vi
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Contents
pp vii-viii
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Contributors
pp ix-xiv
- By Hamid M. Abdolmaleky, Cory Adamson, Paola Allavena, Dimitrios Anastasiou, Johanna Apfel, Surinder K. Batra, Mark E. Burkard, Amancio Carnero, Michael J. Clemens, Jeanette Gowen Cook, Isabel Dominguez, Jeremy S. Edwards, Wafik S. El-Deiry, Androulla Elia, Mohammad R. Eskandari, Aurora Esquela-Kerscher, Manel Esteller, Rob M. Ewing, Douglas V. Faller, Kristopher Frese, Xijin Ge, Giovanni Germano, Daniel A. Haber, William C. Hahn, Antoine Ho, Christine Iacobuzio-Donahue, Sergii Ivakhno, Prasad V. Jallepalli, Rosanne Jones, Sharyn Katz, Arnaud Krebs, Karl Krueger, Arthur W. Lambert, Adam Lerner, Holly Lewis, Jason W. Locasale, Giselle Y. López, Shyamala Maheswaran, Alberto Mantovani, José Ignacio Martín-Subero, Simon J. Morley, Oliver Müller, Kathleen R. Nevis, Sait Ozturk, Panagiotis Papageorgis, Jignesh R. Parikh, Steven M. Powell, Kimberly L. Raiford, Andrew M. Rankin, Patricia Reischmann, Simon Rosenfeld, Marc Samsky, Anthony Scott, Shantibhusan Senapati, Yashaswi Shrestha, Anurag Singh, Rakesh K. Singh, Gromoslaw A. Smolen, Sudhir Srivastava, Simon Tavaré, Sam Thiagalingam, László Tora, David Tuveson, Asad Umar, Matthew G. Vander Heiden, Cyrus Vaziri, Zhenghe John Wang, Kevin Webster, Chen Khuan Wong, Yu Xia, Hai Yan, Jian Yu, Lihua Yu, Min Yu, Lin Zhang, Jin-Rong Zhou
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Preface
pp xv-xvi
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Part 1 - Introduction to modular organization of the networks of gene functions and cancer
pp 1-34
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Chapter 1 - Systems biology of cancer progression
pp 1-6
- By Sam Thiagalingam
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Chapter 2 - Lessons from cancer genome sequencing
pp 7-19
- By Antoine Ho, Jeremy S. Edwards
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Chapter 3 - Application of bioinformatics to analyze the expression of tissue-specific and housekeeping genes in cancer
pp 20-34
- By Xijin Ge
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Part 2 - Alterations in the regulatory networks of cellular and molecular events
pp 35-92
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Chapter 4 - Events at DNA replication origins and genome stability
pp 35-55
- By Kathleen R. Nevis, Kimberly L. Raiford, Cyrus Vaziri, Jeanette Gowen Cook
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Chapter 5 - Systems biology approaches bring new insights in the understanding of global gene regulatory mechanisms and their deregulation in cancer
pp 56-69
- By Arnaud Krebs, László Tora
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Chapter 6 - Regulation and dysregulation of protein synthesis in cancer cells
pp 70-92
- By Michael J. Clemens, Androulla Elia, Simon J. Morley
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Part 3 - Events responsible for aberrant genetic and epigenetic codes in cancer
pp 93-168
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Chapter 7 - Genomic instability and carcinogenesis
pp 93-112
- By Mark E. Burkard, Prasad V. Jallepalli
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Chapter 8 - Epigenomic code
pp 113-133
- By José Ignacio Martín-Subero, Manel Esteller
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Chapter 9 - MicroRNA epigenetic systems and cancer
pp 134-153
- By Holly Lewis, Aurora Esquela-Kerscher
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Chapter 10 - Dietary and environmental influences on the genomic and epigenomic codes in cancer
pp 154-168
- By Hamid M. Abdolmaleky, Mohammad R. Eskandari, Jin-Rong Zhou
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Part 4 - Functional networks of events that modulate phenotypic manifestation of cancer
pp 169-322
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Chapter 11 - Regulatory signaling networks in cell transformation and cancer
pp 169-182
- By Yashaswi Shrestha, William C. Hahn
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Chapter 12 - RAS signaling networks
pp 183-192
- By Douglas V. Faller, Andrew M. Rankin
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Chapter 13 - PI3K pathway in cancer
pp 193-203
- By Amancio Carnero
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Chapter 14 - TGFβ and BMP signaling in cancer
pp 204-221
- By Panagiotis Papageorgis, Arthur W. Lambert, Sait Ozturk, Sam Thiagalingam
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Chapter 15 - The Wnt signaling network in cancer
pp 222-255
- By Johanna Apfel, Jignesh R. Parikh, Patricia Reischmann, Rob M. Ewing, Oliver Müller, Yu Xia, Isabel Dominguez
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Chapter 16 - Apoptotic pathways and cancer
pp 256-272
- By Jian Yu, Lin Zhang
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Chapter 17 - Molecular links between inflammation and cancer
pp 273-281
- By Paola Allavena, Giovanni Germano, Alberto Mantovani
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Chapter 18 - Cancer metastasis
pp 282-294
- By Sait Ozturk, Arthur W. Lambert, Chen Khuan Wong, Panagiotis Papageorgis, Sam Thiagalingam
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Chapter 19 - Cancer metabolism
pp 295-308
- By Dimitrios Anastasiou, Jason W. Locasale, Matthew G. Vander Heiden
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