Biology and Pathology of the Oocyte: Role in Fertility, Medicine and Nuclear Reprograming

doi:10.1017/CBO9781139135030

The human egg - the rarest and most rapidly aging cell in the body - is a topic of intense scientific study. Assisted reproduction clinics are constantly vying to improve success rates - choosing the best gametes is a key step in this process. This new edition of what one reviewer of the first edition described as 'possibly the definitive work on the oocyte' covers the development, biology and pathology of the oocyte, and technologies to manipulate, enhance and control fertility. These technologies are used to overcome infertility, avoid inherited diseases, and create genetically engineered embryos from stem cells and cloning. This progress would have been impossible without the myriad of scientific and technical developments covered in this book. The new edition is thoroughly updated and includes major new research on reprogramming, oocyte molecular development, cryopreservation and viability. We are in exciting times for the egg.

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Contents

Frontmatter
pp i-iv
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Dedication
pp v-vi
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Contents
pp vii-viii
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List of Contributors
pp ix-xii
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Preface
pp xiii-xiv
- By Alan Trounson, Californian Institute for Regenerative Medicine, San Francisco, CA, USA, Roger Gosden, Jamestowne Bookworks,Williamsburg, VA, USA, Ursula Eichenlaub-Ritter, Faculty of Biology, Institute of Gene Technology/Microbiology, University of Bielefeld, Bielefeld, Germany
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Section 1 - Historical perspective
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1 - Insights into the amphibian egg to understand the mammalian oocyte
pp 1-11
- By Kei Miyamoto, Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK, John B. Gurdon, Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK
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Section 2 - Life cycle
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2 - Ontogeny of the mammalian ovary
pp 12-23
- By Anne Grete Byskov, Laboratory of Reproductive Biology, Juliane Marie Center, Rigshospitalet, Copenhagen, Denmark, Claus Yding Andersen, Laboratory of Reproductive Biology, Juliane Marie Centre, University Hospital of Copenhagen, and Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark
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3 - Gene networks in oocyte meiosis
pp 24-37
- By Swapna Mohan, Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA, Paula E. Cohen, Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
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4 - Follicle formation and oocyte death
pp 38-49
- By Melissa E. Pepling, Department of Biology, Syracuse University, Syracuse, NY, USA
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5 - The early stages of follicular growth
pp 50-61
- By Alain Gougeon, CRCL, UMR INSERM and CNRS, Faculté de Médecine Laennec, Lyon, France
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6 - Follicle and oocyte developmental dynamics
pp 62-72
- By Aaron J. W. Hsueh, Program of Reproductive and Stem Cell Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA, USA, Kazuhiro Kawamura, Department of Obstetrics and Gynecology, St. Mariana University School of Medicine, Kawasaki, Japan
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7 - Mouse models to identify genes throughout oogenesis
pp 73-80
- By Jia Peng, Departments of Molecular and Human Genetics, and Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA, Qinglei Li, Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX, USA, Martin M. Matzuk, Departments of Molecular and Human Genetics, Pathology and Immunology, Molecular and Cellular Biology, and Pharmacology, Baylor College of Medicine, Houston, TX, USA
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Section 3 - Developmental biology
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8 - Structural basis for oocyte–granulosa cell interactions
pp 81-98
- By Ursula Eichenlaub-Ritter, Faculty of Biology, Institute of Gene Technology/Microbiology, University of Bielefeld, Bielefeld, Germany, Carlos Plancha, Unidade de Biologia da Reprodução, Instituto de Histologia e Biologia da Deservolvimento, Faculdade de Medicina de Lisboa, Lisbon and Centro Médico de Assistência à Reprodução – CEMEARE, Lisbon, Portugal
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9 - Differential gene expression mediated by oocyte–granulosa cell communication
pp 99-108
- By Saiichi Furukawa, University of Tokyo, Tokyo, Japan, Koji Sugiura, University of Tokyo, Tokyo, Japan
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10 - Hormones and growth factors in the regulation of oocyte maturation
pp 109-118
- By Marco Conti, Center for Reproductive Sciences and The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Department of Obstetrics and Gynecology and Reproductive Sciences, University of California, San Francisco, CA, USA
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11 - Getting into and out of oocyte maturation
pp 119-141
- By Hayden Homer, Mammalian Oocyte and Embryo Research Laboratory, Cell and Developmental Biology, Division of Biosciences and Reproductive Medicine Unit, Institute for Women’s Health, UCL, London, UK
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12 - Chromosome behavior and spindle formation in mammalian oocytes
pp 142-153
- By Heide Schatten, Department of Veterinary Pathobiology, University of Missouri, Columbia, MO, USA, Sun Qing-Yuan, State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
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13 - Transcription, accumulation, storage, recruitment, and degradation of maternal mRNA in mammalian oocytes
pp 154-163
- By Santhi Potireddy, Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA, USA, Dasari Amarnath, Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA, USA, Keith E. Latham, Department of Animal Science, College of Agriculture, Michigan State University, East Lansing, MI, USA
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14 - Setting the stage for fertilization: transcriptome and maternal factors
pp 164-176
- By Kim Boram, Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA, Coonrod Scott A., Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
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15 - Egg activation: initiation and decoding of Ca2+ signaling
pp 177-186
- By John Carroll, Department of Anatomy and Developmental Biology, School of Biomedical Sciences, Monash University, Melbourne, Australia, Karl Swann, Institute of Molecular and Experimental Medicine, Cardif University School of Medicine, Cardif, UK
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16 - In vitro growth and differentiation of oocytes
pp 187-199
- By Hang Yin, Center for Reproductive Medicine and Infertility, Weill Medical College of Cornell University, NewYork, NY, USA, Roger Gosden, Jamestowne Bookworks,Williamsburg, VA, USA
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17 - Metabolism of the follicle and oocyte in vivo and in vitro
pp 200-211
- By Helen M. Picton, Division of Reproduction and Early Development, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, UK, Karen E. Hemmings, Division of Reproduction and Early Development, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, UK
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18 - Improving oocyte maturation in vitro
pp 212-223
- By Jeremy G. Thompson, Research Centre for Reproductive Health, Robinson Institute, School of Paediatrics and Reproductive Health,The University of Adelaide, Adelaide, Australia, Robert B. Gilchrist, Research Centre for Reproductive Health, Robinson Institute, School of Paediatrics and Reproductive Health, The University of Adelaide, Adelaide, Australia
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Section 4 - Imprinting and reprogramming
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19 - Human genes modulating primordial germ cell and gamete formation
pp 224-235
- By Valerie L. Baker, Department of Obstetrics and Gynecology, Reproductive Endocrinology and Infertility, Stanford School of Medicine, Palo Alto, CA, USA, Ruth Lathi, Department of Obstetrics and Gynecology, Reproductive Endocrinology and Infertility, Stanford School of Medicine, Palo Alto, CA, USA, Renee A. Reijo Pera, Center for Human Embryonic Stem Cell Research and Education, Institute for Stem Cell Biology and Regenerative Medicine, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Palo Alto, CA, USA
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20 - In vitro differentiation of germ cells from stem cells
pp 236-249
- By Fumihiro Sugawa, Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Münster, Germany, Karin Hübner, Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Münster, Germany, Hans R. Schöler, Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine and Medical Faculty, University of Münster, Münster, Germany
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21 - Parthenogenesis and parthenogenetic stem cells
pp 250-260
- By Tiziana A.L. Brevini, Laboratory of Biomedical Embryology, Centre for Stem Cell Research UNISTEM, Università degli Studi di Milano, Milan, Italy, Fulvio Gandolfi, Laboratory of Biomedical Embryology, Centre for Stem Cell Research UNISTEM, Universit degli Studi di Milano, Milan, Italy
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Biology and Pathology of the Oocyte

Role in Fertility, Medicine and Nuclear Reprograming

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