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Assessment of optimal combinations of therapeutic probiotics for depression, anxiety, and stress

Published online by Cambridge University Press:  18 March 2024

Yafang Yang ,
Ligang Yang ,
Min Wan ,
Da Pan ,
Guiju Sun  and
Chao Yang Open the ORCID record for Chao Yang [Opens in a new window]
Yafang Yang
Affiliation:
Department of Public Health and Preventive Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi 214000, China
Ligang Yang
Affiliation:
Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, China
Min Wan
Affiliation:
Rongxiang Community Health Service Center, Wuxi 214000, China
Da Pan
Affiliation:
Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, China
Guiju Sun
Affiliation:
Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, China
Chao Yang*
Affiliation:
Department of Public Health and Preventive Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi 214000, China
*
Corresponding author: Chao Yang; Email: chaoyang@jiangnan.edu.cn
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Abstract

Background

Accumulating data show that probiotics may be beneficial for reducing depressive, anxiety, and stress symptoms. However, the best combinations and species of probiotics have not been identified. The objective of our study was to assess the most effective combinations and components of different probiotics through network meta-analysis.

Method

A systematic search of four databases, PubMed, Web of Science, Cochrane, and Embase, was conducted from inception to 11 January 2024. The GRADE framework was used to assess the quality of evidence contributing to each network estimate.

Results

We deemed 45 trials eligible, these included 4053 participants and 10 types of interventions. The quality of evidence was rated as high or moderate. The NMA revealed that Bifidobacterium exhibited a greater probability of being the optimal probiotic species for improving anxiety symptoms (SMD = −0.80; 95% CI −1.49 to −0.11), followed by Lactobacillus (SMD = −0.49; 95% CI −0.85 to −0.12). In addition, for multiple strains, compared with the other interventions, Lactobacillus + Bifidobacterium (SMD = −0.41; 95% CI −0.73 to −0.10) had a positive effect on depression.

Conclusion

The NMA revealed that Lactobacillus and Bifidobacterium had prominent efficacy in the treatment of individuals with anxiety, depression, and combination of Lactobacillus + Bifidobacterium had a similar effect. With few direct comparisons available between probiotic species, this NMA may be instrumental in shaping the guidelines for probiotic treatment of psychological disorders.

Keywords

anxietydepressionnetwork meta-analysisprobioticsstress

Information

Type
Original Article
Information
Psychological Medicine , Volume 54 , Issue 10 , July 2024 , pp. 2547 - 2561
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Copyright
Copyright © The Author(s), 2024. Published by Cambridge University Press

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