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Neurodevelopment outcomes in the first 5 years of the life of children with transposition of the great arteries surgically corrected in the neonatal period: systematic review and meta-analysis

Published online by Cambridge University Press:  15 November 2023

Catarina Soares Open the ORCID record for Catarina Soares [Opens in a new window] ,
Rafael José Vieira ,
Sandra Costa ,
Rita Moita ,
Mariana Andrade  and
Hercília Guimarães
Catarina Soares*
Affiliation:
Faculty of Medicine of Porto University, Porto, Portugal
Rafael José Vieira
Affiliation:
Department of Community Medicine, Information and Health Decision Sciences (MEDCIDS), Faculty of Medicine of Porto University, Porto, Portugal Centre for Health Technology and Services Research, Health Research Network (CINTESIS@RISE), Faculty of Medicine of Porto University, Porto, Portugal
Sandra Costa
Affiliation:
Faculty of Medicine of Porto University, Porto, Portugal Neonatology Department, Centro Hospitalar Universitário São João, Porto, Portugal
Rita Moita
Affiliation:
Neonatology Department, Centro Hospitalar Universitário São João, Porto, Portugal
Mariana Andrade
Affiliation:
Pediatrics Department, Centro Hospitalar Universitário São João, Porto, Portugal
Hercília Guimarães
Affiliation:
Faculty of Medicine of Porto University, Porto, Portugal
*
Corresponding author: Catarina Soares; Email: catarinasoares7a@gmail.com
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Abstract

Congenital Heart Defects are the most common abnormalities at birth, resulting in many short- and long-term consequences.

Objectives:

In patients with transposition of the great arteries, surgical correction may achieve definitive treatment, so a thorough knowledge of the long-term outcomes, particularly neurodevelopment outcomes, is essential. Therefore, we conducted a systematic review and meta-analysis to study the neurodevelopment outcomes in the first 5 years of the life of children submitted to corrective surgery for transposition of the great arteries in the neonatal period.

Methods:

A total of 17 studies from 18 reports were included, assessing 809 individuals with surgically corrected transposition of the great arteries. The neurodevelopmental outcomes were assessed with the Bayley Scales of Infant and Toddler Development (BSID) and the Wechsler Intelligence Scale for Children (WISC).

Results:

Mean Mental Development Index (MDI) and Psychomotor Development Index (PDI) were within the average values from 1 to 3 years of age, although the proportion of children scoring more than 1 standard deviation below the mean in PDI, MDI, motor, and language composite scores was significantly higher than in the general population. From 4 to 5 years, mean full-scale global intelligence quotient (IQ), verbal IQ, and performance IQ scores did not differ significantly from the general population.

Conclusion:

This study revealed neurodevelopment scores within the normal range at 5 years of age in children submitted to corrective surgery for transposition of the great arteries in the neonatal period. However, these early outcomes may not adequately predict long-term outcomes. Further studies are needed to identify specific risk factors and early markers of later impairment to guide the establishment of early interventions.

Keywords

Neurodevelopmenttransposition of the great arteriesneonatal periodarterial switch operation5 years

Information

Type
Review
Information
Cardiology in the Young , Volume 33 , Issue 12 , December 2023 , pp. 2471 - 2480
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Copyright
© The Author(s), 2023. Published by Cambridge University Press

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