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Feeling of Cold Hands and Feet is a Highly Heritable Phenotype

Published online by Cambridge University Press:  28 March 2012

Yoon-Mi Hur ,
Jeong-Ho Chae ,
Ki Wha Chung ,
Jung Jin Kim ,
Hoe-Uk Jeong ,
Jong Woo Kim ,
Sung Yum Seo  and
Kyung Soo Kim
Yoon-Mi Hur*
Affiliation:
Mokpo National University, South Korea
Jeong-Ho Chae
Affiliation:
Department of Psychiatry, Seoul St. Mary's Hospital, The Catholic University of Korea
Ki Wha Chung
Affiliation:
Department of Biological Science, Kongju National University, South Korea
Jung Jin Kim
Affiliation:
Department of Psychiatry, Seoul St. Mary's Hospital, The Catholic University of Korea
Hoe-Uk Jeong
Affiliation:
Mokpo National University, South Korea
Jong Woo Kim
Affiliation:
College of Oriental Medicine, Kyunghee University Hospital, South Korea
Sung Yum Seo
Affiliation:
Department of Biological Science, Kongju National University, South Korea
Kyung Soo Kim
Affiliation:
Department of Family Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea
*
Address for Correspondence: Yoon-Mi Hur, MokpoNational University, 61 Dorim-ri, Muan-gun, Jeonnam,South Korea. Email: ymhur@mokpo.ac.kr

Abstract

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The prevalence of the feeling of cold hands and feet (FCHF) is high in thegeneral population but the etiology of FCHF is largely unknown. The aim of thepresent study was to explore whether the FCHF is heritable. Eight hundred andninety-four pairs of twins completed a question about FCHF. Tetrachoriccorrelations for FCHF were .58, .29, .67, .52, and .04 for monozygotic male,dizygotic male, monozygotic female, and dizygotic female twins, respectively.Model-fitting analyses suggested that in the best fitting model, additivegenetic and nonshared environmental variance including measurement error were64% (95% CI: 55%-72%) and 36% (28%-45%), respectively. Sex differences ingenetic and environmental influences were not significant.

Keywords

cold hands and feetgeneticstwinenvironmentRaynaud's Phenomenon

Information

Type
Articles
Information
Twin Research and Human Genetics , Volume 15 , Issue 2 , April 2012 , pp. 166 - 169
Copyright
Copyright © Cambridge University Press 2012