We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
The Indian Pulsar Timing Array (InPTA) employs unique features of the upgraded Giant Metrewave Radio Telescope (uGMRT) to monitor dozens of the International Pulsar Timing Array (IPTA) millisecond pulsars (MSPs), simultaneously in the 300–500 MHz and the 1260–1460 MHz bands. This dual-band approach ensures that any frequency-dependent delays are accurately characterised, significantly improving the timing precision for pulsar observations, which is crucial for pulsar timing arrays. We present details of InPTA’s second data release that involves 7 yr of data on 27 IPTA MSPs. This includes sub-banded times of arrival (ToAs), dispersion measures (DM), and initial timing ephemerides for our MSPs. A part of this dataset, originally released in InPTA’s first data release, is being incorporated into IPTA’s third data release, which is expected to detect and characterise nanohertz gravitational waves (GWs) in the coming years. The entire dataset is reprocessed in this second data release providing some of the highest precision DM estimates so far and interesting solar wind-related DM variations in some pulsars. This is likely to characterise the noise introduced by the dynamic inter-stellar ionised medium much better than the previous release thereby increasing sensitivity to any future GW search.
Will voters punish incumbents for psychological distress associated with public policy during external shocks? This study examines this question in the empirical context of the first wave of the COVID-19 pandemic in India, utilizing three novel cross-sectional surveys conducted in the first three weeks of June 2020, immediately after the national lockdown policy was officially revoked. We find that propensity to vote for the nationally incumbent Bharatiya Janata Party (if hypothetical elections were held on the day of the survey) was negatively correlated with mental stress from routine disruptions in mobility (Week 1); worsening mental health (Week 2); and emotion-focused coping (Week 3). We show that these effects are strongest in BJP-ruled states. We argue that psychological distress shaped political attitudes in the midst of the pandemic and this effect was conditional on the source of distress and moderated by governmental clarity of responsibility.
The Australian SKA Pathfinder (ASKAP) offers powerful new capabilities for studying the polarised and magnetised Universe at radio wavelengths. In this paper, we introduce the Polarisation Sky Survey of the Universe’s Magnetism (POSSUM), a groundbreaking survey with three primary objectives: (1) to create a comprehensive Faraday rotation measure (RM) grid of up to one million compact extragalactic sources across the southern $\sim50$% of the sky (20,630 deg$^2$); (2) to map the intrinsic polarisation and RM properties of a wide range of discrete extragalactic and Galactic objects over the same area; and (3) to contribute interferometric data with excellent surface brightness sensitivity, which can be combined with single-dish data to study the diffuse Galactic interstellar medium. Observations for the full POSSUM survey commenced in May 2023 and are expected to conclude by mid-2028. POSSUM will achieve an RM grid density of around 30–50 RMs per square degree with a median measurement uncertainty of $\sim$1 rad m$^{-2}$. The survey operates primarily over a frequency range of 800–1088 MHz, with an angular resolution of 20” and a typical RMS sensitivity in Stokes Q or U of 18 $\mu$Jy beam$^{-1}$. Additionally, the survey will be supplemented by similar observations covering 1296–1440 MHz over 38% of the sky. POSSUM will enable the discovery and detailed investigation of magnetised phenomena in a wide range of cosmic environments, including the intergalactic medium and cosmic web, galaxy clusters and groups, active galactic nuclei and radio galaxies, the Magellanic System and other nearby galaxies, galaxy halos and the circumgalactic medium, and the magnetic structure of the Milky Way across a very wide range of scales, as well as the interplay between these components. This paper reviews the current science case developed by the POSSUM Collaboration and provides an overview of POSSUM’s observations, data processing, outputs, and its complementarity with other radio and multi-wavelength surveys, including future work with the SKA.
We present the Evolutionary Map of the Universe (EMU) survey conducted with the Australian Square Kilometre Array Pathfinder (ASKAP). EMU aims to deliver the touchstone radio atlas of the southern hemisphere. We introduce EMU and review its science drivers and key science goals, updated and tailored to the current ASKAP five-year survey plan. The development of the survey strategy and planned sky coverage is presented, along with the operational aspects of the survey and associated data analysis, together with a selection of diagnostics demonstrating the imaging quality and data characteristics. We give a general description of the value-added data pipeline and data products before concluding with a discussion of links to other surveys and projects and an outline of EMU’s legacy value.
To examine the risk of perinatal mental illness, including new diagnoses and recurrent use of mental healthcare, comparing women with and without traumatic brain injury (TBI), and to identify injury-related factors associated with these outcomes among women with TBI.
Methods
We conducted a population-based cohort study in Ontario, Canada, of all obstetrical deliveries to women in 2012–2021, excluding those with mental healthcare use in the year before conception. The cohort was stratified into women with no remote mental illness history (to identify new mental illness diagnoses between conception and 365 days postpartum) and those with a remote mental illness history (to identify recurrent illnesses). Modified Poisson regression generated adjusted relative risks (aRRs) (1) comparing women with and without TBI and (2) according to injury-related variables (i.e., number, severity, timing, mechanism and intent) among women with TBI.
Results
There were n = 12,724 women with a history of TBI (mean age: 27.6 years [SD, 5.5]) and n = 786,317 without a history of TBI (mean age: 30.6 years [SD, 5.0]). Women with TBI were at elevated risk of a new mental illness diagnosis in the perinatal period compared to women without TBI (18.5% vs. 12.7%; aRR: 1.31, 95% confidence interval [CI]: 1.24–1.39), including mood and anxiety disorders. Women with a TBI were also at elevated risk for recurrent use of mental healthcare perinatally (35.5% vs. 27.8%; aRR: 1.18, 95% CI: 1.14–1.22), including mood and anxiety, psychotic, substance use and other mental health disorders. Among women with a history of TBI, the number of TBI-related healthcare encounters was positively associated with an elevated risk of new-onset mental illness.
Conclusions
These findings demonstrate the need for providers to be attentive to the risk for perinatal mental illness in women with a TBI. This population may benefit from screening and tailored mental health supports and treatment options.
Zonisamide (1-(1,2-Benzoxazol-3-yl)methanesulphonamide) is a sulphonamide derivative with a molecular weight of 212.2 and a molecular formula of C8H8N2O3S.
Fludrocortisone acetate (9α-fluoro-11β,17α,21-trihydroxypregn-4-ene-3,10-dione 21-acetate) is a synthetic adrenal steroid. It has a molecular weight of 422.5 and a molecular formula of C23H31FO6.
Amitriptyline hydrochloride (3-(10,11-dihydro-5H-dibenzo[a,d]cycloheptene-5-ylidene)-N,N-dimethylpropan-1-amine; hydrochloride) has a molecular weight of 313.9 and a molecular formula of C20H23N,HCl. Amitriptyline is usually given as the hydrochloride and doses are expressed in terms of this salt. Amitriptyline hydrochloride 75 mg is equivalent to about 66.3 mg of the base.
Oxybutynin (4-diethylaminobut-2-ynyl 2-cyclohexyl-2-phenylglycolate; 4-(diethylamino)-2-butynyl α-phenylcyclohexaneglycolic acid ester) has a molecular weight of 357.5 and a molecular formula of C22H31NO3.
Nortriptyline hydrochloride (3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)propyl(methyl)amine hydrochloride) is a dibenzocycloheptadiene tricyclic antidepressant with a molecular weight of 299.8 and an empirical formula of C19H21N,HCl.
Droxidopa ( (–)-threo-3-(3,4-dihydroxyphenyl)-l-serine) is an odourless, tasteless, white to off-white crystalline powder, which is slightly soluble to water. It has a molecular weight of 213.2 and a molecular formula of C9H11NO5.
Citalopram (1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-3H-2-benzofuran-5-carbonitrile) is a fine white to off-white powder with a molecular weight of 324.4 and an empirical formula of C20H21FN2O. Citalopram 20 mg is equivalent to 24.99 mg citalopram hydrobromide.
Amantadine (tricyclo[3.3.1.1]decan-1-amine, 1-adamantanamine, 1-aminoadamantane) is a white or nearly white crystalline, odourless, and bitter-tasting powder, with a molecular weight of 151.25 and an empirical formula of C10H17N. Amantadine is a tricyclic amine with two available preparations, amantadine hydrochloride, which is given orally, and the salt amantadine sulphate, which is administered either orally or IV.
Melatonin (N-acetyl-5-methoxytryptamine or N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide) is a tryptophan-derived hormone and an antioxidant, produced primarily in the pineal gland. Exogenous melatonin is an amphiphilic, white–cream to yellowish crystalline powder, unchanged in the entire pH range. It has a molecular weight of 232.28 and an empirical formula of C13H16N2O2, while its chemical structure resembles serotonin.
Istradefylline (8-[(1E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-dethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione) is a xanthine derivative with a molecular weight of 384.4 and an empirical formula of C20H24N4O4.
Apomorphine hydrochloride (6aβ-aporphine-10,11-diol hydrochloride hemihydrate; (R)-10,11-dihydroxy-6a-aporphine hydrochloride hemihydrate; (6aR)-5,6,6a,7-tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diol hydrochloride hemihydrate) has a molecular weight of 303.8 and a molecular formula of C17H18ClNO2.
Midodrine hydrochloride (2-amino-N-(β-hydroxy-2,5-dimethoxyphenethyl)acetamide hydrochloride or (RS)-N-(β-hydroxy-2,5-dimethoxyphenethyl)glycinamide hydrochloride), molecular weight 290.74 and a molecular formula of C12H18N2O4,HCl.