We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
With the aim of producing a 3D representation of tumors, imaging and molecular annotation of xenografts and tumors (IMAXT) uses a large variety of modalities in order to acquire tumor samples and produce a map of every cell in the tumor and its host environment. With the large volume and variety of data produced in the project, we developed automatic data workflows and analysis pipelines. We introduce a research methodology where scientists connect to a cloud environment to perform analysis close to where data are located, instead of bringing data to their local computers. Here, we present the data and analysis infrastructure, discuss the unique computational challenges and describe the analysis chains developed and deployed to generate molecularly annotated tumor models. Registration is achieved by use of a novel technique involving spherical fiducial marks that are visible in all imaging modalities used within IMAXT. The automatic pipelines are highly optimized and allow to obtain processed datasets several times quicker than current solutions narrowing the gap between data acquisition and scientific exploitation.
Technology and Society: A World History explores the creative power of humanity from the age of stone tools to the digital revolution. It introduces technology as a series of systems that allowed us to solve real-world problems and create a global civilization. The history of technology is also the history of the intellectual and cultural place of our tools and devices. With a broad view of technology, we can see that some of the most powerful technologies such as education and government produce no physical object but have allowed us to coordinate our inventive skills and pass knowledge through the ages. Yet although all human communities depend on technology, there are unexpected consequences from the use of technology which, as Ede shows, form a crucial part of this rich story.
Fibrinolysis is an acceptable treatment for acute ST-segment elevation myocardial infarction (STEMI) when primary percutaneous coronary intervention (PCI) cannot be performed within 120 minutes. The American Heart Association has recommended Emergency Medical Services (EMS) interventions such as prehospital fibrinolysis (PHF), prehospital electrocardiogram (ECG), and hospital bypass direct to PCI center. Nova Scotia, Canada has incorporated these interventions into a unique province-wide approach to STEMI care. A retrospective cohort analysis comparing the primary outcome of 30-day mortality for patients receiving either prehospital or emergency department (ED) fibrinolysis (EDF) to patients transported directly by EMS from community or regional ED for primary PCI was conducted.
Methods:
This retrospective, population-based cohort study included all STEMI patients in Nova Scotia who survived to hospital admission from July 2011 through July 2013. Three provincial databases were used to collect demographic, 30-day mortality, hospital readmission, and rescue PCI data. The results were grouped and compared according to reperfusion strategy received: PHF, EDF, patients brought by ambulance via EMS direct to PCI (EMS to PCI), and ED to PCI (ED to PCI).
Results:
There were 1,071 STEMI patients included with 145 PHF, 606 EDF, 98 EMS to PCI, and 222 ED to PCI. There were no significant differences in 30-day mortality across groups (n, %): PHF 5(3); EDF 36(6); EHS to PCI <5(2); and ED to PCI 10(4); P = .28. There was no significant difference in patients receiving fibrinolysis who underwent rescue PCI.
Conclusions:
Prehospital fibrinolysis incorporated into a province-wide approach to STEMI treatment is feasible with no observed difference in patient 30-day mortality outcomes observed.
In Asia the combination of good agricultural land, growing populations and rich empires led to a period of great creativity. Many of the most historically important inventions, including silk, paper, gunpowder and the horse collar, made China a technological leader. Another factor in the development and spread of technology was the establishment of a well-educated bureaucracy who could develop, spread and use new forms of technology. These characteristics allowed Chinese rulers to take on large projects such as the Great Wall and the Magic Canal, which involved tens of thousands of workers. China’s wealth and technological strength was unrivaled, but that contributed to a period of lower technological development since there was no need to innovate and society became more rigid. This was supported by Taoist and Confucian philosophies that favored social stability and discouraged change. As a result, Chinese technologies tended to get bigger and more refined rather than introducing innovations.
To be human is to use technology. Everything we do, from telling stories around a campfire to examining the farthest reaches of the universe, is done using technology. The web of technology that makes human life possible is so pervasive that we are often only aware of it when it breaks down or suddenly changes. It is so closely tied to human existence that we identify groups of people by their access to technology, comparing “industrialized” countries to “developing” countries. We even classify vast periods of human history on the basis of technology such as the Neolithic period or “New Stone Age,” followed by the “Bronze Age.”
Some scholars have described technology as the ability to make tools, while others see it as a kind of framework that surrounds us. This book argues that technology does not exist on its own as something separate from people and the societies we create. At a fundamental level, we are our technology.
There is always a danger when discussing the earliest developments in technology that any observation will be made obsolete by a new discovery. Archeologists and anthropologists continue to build the picture of the lives of our ancient ancestors, and each discovery makes our common history richer and more robust. For example, recent discoveries have pushed back the date for the appearance of tool use among our hominin relatives, have found entirely new settlements, and with the help of DNA evidence have started to create a much more detailed chronological and geographic map of the spread of humans across the globe. As work continues, we will know more about the distant past in the future than we do today. Thus, the historian must write with a certain caution, recognizing that a discovery made next week or next year could radically change our understanding of the past.