This study aimed to determine which machine learning model is most suitable for predicting noise-induced hearing loss and the effect of tinnitus on the models’ accuracy.

Two hundred workers employed in a metal industry were selected for this study and tested using pure tone audiometry. Their occupational exposure histories were collected, analysed and used to create a dataset. Eighty per cent of the data collected was used to train six machine learning models and the remaining 20 per cent was used to test the models.

Eight workers (40.5 per cent) had bilaterally normal hearing and 119 (59.5 per cent) had hearing loss. Tinnitus was the second most important indicator after age for noise-induced hearing loss. The support vector machine was the best-performing algorithm, with 90 per cent accuracy, 91 per cent F1 score, 95 per cent precision and 88 per cent recall.

The use of tinnitus as a risk factor in the support vector machine model may increase the success of occupational health and safety programmes.

Acetylcholinesterase inhibitors are the focus of interest in the management of schizophrenia. We aimed to investigate the effects of acute galangin administration, a flavonoid compound with acetylcholinesterase inhibiting activity, on schizophrenia-associated cognitive deficits in rats and schizophrenia models in mice.

Apomorphine-induced prepulse inhibition (PPI) disruption for cognitive functions, nicotinic, muscarinic, and serotonergic mechanism involvement, and brain acetylcholine levels were investigated in Wistar rats. Apomorphine-induced climbing, MK-801-induced hyperlocomotion, and catalepsy tests were used as schizophrenia models in Swiss albino mice. The effects of galangin were compared with acetylcholinesterase inhibitor donepezil, and typical and atypical antipsychotics haloperidol and olanzapine, respectively.

Galangin (50,100 mg/kg) enhanced apomorphine-induced PPI disruption similar to donepezil, haloperidol, and olanzapine (p < 0.05). This effect was not altered in the combination of galangin with the nicotinic receptor antagonist mecamylamine (1 mg/kg), the muscarinic receptor antagonist scopolamine (0.05 mg/kg), or the serotonin-1A receptor antagonist WAY-100635 (1 mg/kg) (p > 0.05). Galangin (50,100 mg/kg) alone increased brain acetylcholine concentrations (p < 0.05), but not in apomorphine-injected rats (p > 0.05). Galangin (50 mg/kg) decreased apomorphine-induced climbing and MK-801-induced hyperlocomotion similar to haloperidol and olanzapine (p < 0.05), but did not induce catalepsy, unlike them.

We suggest that galangin may help enhance schizophrenia-associated cognitive deficits, and nicotinic, muscarinic cholinergic, and serotonin-1A receptors are not involved in this effect. Galangin also exerted an antipsychotic-like effect without inducing catalepsy and may be considered as an advantageous antipsychotic agent.