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1 results

  • Nanoscale Forces at the Heart of Staphylococcus Infections

  • Ruchirej Yongsunthon, Francis Paul Vellano, Brian H. Lower, Vance G. Fowler, Emily Alexander, Steven K. Lower
  • Journal:
    MRS Online Proceedings Library Archive / Volume 1025 / 2007
    Published online by Cambridge University Press:
    01 February 2011, 1025-B04-10
    Print publication:
    2007

  • Staphylococcus aureus is one of the most frequently isolated bacteria from infected medical implants. S. aureus has the capacity to adhere to the surface of an implant where it forms a biofilm. We used atomic force microscopy to probe binding forces between a fibronectin-coated tip and isolates of S. aureus, which were obtained from either patients with infected prostheses or healthy humans. A unique force-signature was observed for binding events between the tip and the cells. There is a strong distinction (p=0.01) in the binding force-signature observed for S. aureus isolated from the infected vs. healthy populations. This observation suggests a fundamental correlation between nanometer scale binding forces and the clinical outcome of patients with implanted medical devices.