The Second International Conference on the Frontiers of Plasma Physics and Technology was held in Goa, India, from February 21–25, 2005. This conference explored a number of fundamental and applied plasma physics topics. Special attention was focused on the exploration of frontiers in physics and technology of high energy density plasmas—a topic growing at a very fast pace due to the emergence of extremely powerful laser sources. Reviews on activities and new opportunities for large laser facilities in prominent laboratories of Asia, Europe, and Canada were presented. Talks on recent advances on laser driven Wakefield particle acceleration scheme were very exciting. This technology has a strong potential of revolutionizing the existing accelerator physics, technology, and radiation sources such as synchrotrons and X-ray free-electron lasers. Discussions were also given on the generation of extreme physical conditions similar to those existing in astrophysical objects, under laboratory conditions using intense lasers. This technique may lead to an easy and inexpensive way to simulate and understand a variety of astrophysical phenomena. This aspect of realization of astrophysical conditions in a laboratory has now become reality, and soon may lead to routine experiments. New applications of laser in the designs of light-crafts may soon become reliable.