This essay traces Edward Soja's “geography of labor” in the Mississippi catfish industry. Our interdisciplinary analysis integrates the socioeconomic realities of the Mississippi delta with Steve Yarbrough's literary rendering of that place in his 1999 novel The Oxygen Man. We argue that Yarbrough's novel closely maps changes in Mississippi delta agribusiness and urges readers to reimagine spatial justice in a landscape infamous for racism and poverty.