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1 results

  • Reduced hippocampal volumes and memory loss in patients with early- and late-onset depression

  • Ian Hickie, Sharon Naismith, Philip B. Ward, Keelin Turner, Elizabeth Scott, Philip Mitchell, Kay Wilhelm, Gordon Parker
  • Journal:
    The British Journal of Psychiatry / Volume 186 / Issue 3 / March 2005
    Published online by Cambridge University Press:
    02 January 2018, pp. 197-202
    Print publication:
    March 2005
    • Article
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  • Background

    Hippocampal volume reduction has been reported inconsistently in people with major depression.

    Aims

    To evaluate the interrelationships between hippocampal volumes, memory and key clinical, vascular and genetic risk factors.

    Method

    Totals of 66 people with depression and 20 control participants underwent magnetic resonance imaging and clinical assessment. Measures of depression severity, psychomotor retardation, verbal and visual memory and vascular and specific genetic risk factors were collected.

    Results

    Reduced hippocampal volumes occurred in older people with depression, those with both early-onset and late-onset disorders and those with the melancholic subtype. Reduced hippocampal volumes were associated with deficits in visual and verbal memory performance.

    Conclusions

    Although reduced hippocampal volumes are most pronounced in late-onset depression, older people with early-onset disorders also display volume changes and memory loss. No clear vascular or genetic risk factors explain these findings. Hippocampal volume changes may explain how depression emerges as a risk factor to dementia.