Nearly all US Black children born before 1910 were born in the American South. We use a mixed-methods design to examine Black children’s survival disadvantage over the twentieth century’s turn under the rising regime of Jim Crow. We focus on 1910 Arkansas, taking advantage of within-state heterogeneity in agriculture (plantation vs. subsistence farming), disease environments, and geographic racial concentration (macro-segregation). This one-state focus allows purposive sampling of Works Progress Administration and Behind the Veil oral interviews of Arkansan Black Americans who were born or lived under the state’s Jim Crow regime. We also use the 1910 complete-count Integrated Public Use Microdata Series (IPUMS) linked to US Decennial and 1916 Plantation Censuses to examine race-related differences in child mortality rates among ever-married, parous Arkansas women (n=234,811). Count regression models find the Black-White child mortality gap widest among Arkansas mothers economically tied to plantation vs. subsistence agriculture; exposed to worse health environments; living in tenant farm vs. owned-farm households; and with limited individual resources such as literacy. Oral accounts illustrate how Black children’s lives reflected contextual, living standard, psychosocial, and other health risks associated with the racialized policies and practices of the Jim Crow South; they capture otherwise hidden historical processes that linked the era’s institutional racism and child mortality.