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406 results

Page 1 of 21

  • Exploring the Relationship between Polygenic Scores, Community-Shared Socioeconomic Indicators and Major Depressive Disorder Outcome

  • Dante T. Sepulveda, Jackson G. Thorp, Penelope A. Lind, Nicholas G. Martin, Sarah E. Medland, Brittany L. Mitchell
  • Journal:
    Twin Research and Human Genetics / Volume 28 / Issue 3 / June 2025
    Published online by Cambridge University Press:
    08 July 2025, pp. 241-249
    • Article
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  • Depression, a leading cause of global disability, arises from a multifaceted combination of genetic and environmental components. This study explores the relationship between major depressive disorder (MDD) polygenic scores (PGS), characteristics and symptoms of depression, and community-shared socioeconomic factors derived from postal code data in a cohort of 12,646 individuals from the Australian Genetics of Depression Study (AGDS). Our findings reveal that people living in areas with relatively higher socioeconomic advantages and education/occupation scores are more likely to report experiencing fewer depressive symptoms during their worst depressive period, as well as fewer number of lifetime episodes. Additionally, participants who reported depression onset later in life tend to currently reside in wealthier areas. Interestingly, no significant interaction between genetic and socioeconomic factors was observed, suggesting their independent contribution to depression outcomes. This research underscores the importance of integrating socioeconomic factors into psychiatric evaluation and care, and points to the critical role of public policy in addressing mental health disparities driven by socioeconomic factors. Future research should aim to further elucidate the causal relationships within these associations and explore the potential for integrated genetic and socioeconomic approaches in mental health interventions.

Principles of Medicine in Africa
  • 5th edition
  • Edited by David Mabey, Martin W. Weber, Moffat Nyirenda, Dorothy Yeboah-Manu, Jackson Orem, Laura Benjamin, Michael Marks, Nicholas A. Feasey
  • Published online:
    18 June 2025
    Print publication:
    05 June 2025
  • Principles of Medicine in Africa combines clinical medicine with a rich understanding of the major environmental and cultural influences on health and disease, providing comprehensive guidance for anyone intending to practise medicine in Africa. Presenting disease in the context of family and culture, the effects of inequality and problems of limited resources are addressed. The authors have a wealth of experience in front line healthcare in Africa and provide practical, evidence-based management guidelines for all the common and less common conditions likely to be encountered. This fifth edition has been thoroughly updated to incorporate the latest research findings and management guidelines and there has been much greater involvement of African physicians in the writing and editorial process. The chapters on cancer and non-communicable diseases have been expanded and new chapters have been added on digital health, critical care in a resource-limited setting, antimicrobial resistance, COVID-19 and other emerging infectious diseases.

Page 1 of 21