We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Impulsivity is a multidimensional trait associated with substance use disorders (SUDs), but the relationship between distinct impulsivity facets and stages of substance use involvement remains unclear.
Methods
We used genomic structural equation modeling and genome-wide association studies (N = 79,729–903,147) to examine the latent genetic architecture of nine impulsivity traits and seven substance use (SU) and SUD traits.
Results
We found that the SU and SUD factors were strongly genetically inter-correlated (rG=0.77) but their associations with impulsivity facets differed. Lack of premeditation, negative and positive urgency were equally positively genetically correlated with both the SU (rG=.0.30–0.50) and SUD (rG=0.38–0.46) factors; sensation seeking was more strongly genetically correlated with the SU factor (rG=0.27 versus rG=0.10); delay discounting was more strongly genetically correlated with the SUD factor (rG=0.31 versus rG=0.21); and lack of perseverance was only weakly genetically correlated with the SU factor (rG=0.10). After controlling for the genetic correlation between SU/SUD, we found that lack of premeditation was independently genetically associated with both the SU (β=0.42) and SUD factors (β=0.21); sensation seeking and positive urgency were independently genetically associated with the SU factor (β=0.48, β=0.33, respectively); and negative urgency and delay discounting were independently genetically associated with the SUD factor (β=0.33, β=0.36, respectively).
Conclusions
Our findings show that specific impulsivity facets confer risk for distinct stages of substance use involvement, with potential implications for SUDs prevention and treatment.
The British State intervened in the Port of London in 1800. It did so again a hundred years later by appointing a Royal Commission, which provided the basis for eventual reform in 1908. The immediate reason for the Royal Commission was a dock proposal to abolish free entry to docks by river. But the wider context was long-standing, loudly voiced, shipping company grievances about river governance, licensing of lighterage and compulsory pilotage. The Commission’s conclusion that London should have a port authority was generally accepted. However, issues of constitution and compensation bedevilled the Conservative attempt to legislate. In the event, it was a Liberal government, with all-party support, which established the Port of London Authority, effectively nationalising London’s port. In an ironic coda, the port unions soon discovered their new public employer to be a more formidable opponent than their dock company predecessors had ever been.
London’s seasonal foreign trade reflected its access to northern and continental Europe and the City’s association with the East and West Indies, but coal and other coastal trades dominated daily port activity. London was a tidal river port centred below London Bridge, with waterfront industry spread more widely. Organisationally, it was complex, with many different interests. As foreign trade increased, legal restrictions on landing places for foreign produce were blamed by merchants for congestion. A campaign by mercantile interests for the introduction of docks followed. The author examines the motives here. For leading West India merchants, specialised dock facilities would enable them to control and discipline a directly employed labour force, reducing theft. The eventual outcome, the construction of docks by joint-stock companies, owed much to State support. Its involvement went beyond the introduction of docks. For the government, this was an element of a warehousing scheme designed to develop London as an entrepôt. General port efficiency would be promoted by appointing the Corporation of London as harbour authority.
Besides mercantile, shipping, legal, insurance and financial services, the capital’s maritime connections extended to large-scale manufacturing like shipbuilding, ship repairing, marine engineering, sail-making and sugar baking. Shipping investors, almost exclusively involved in some aspect of sea trade, varied from those holding a few shares to the relative few reliant on ship owning for their income. The wealthiest shipowners and merchants, as well as the Royal Navy, were among the customers of London’s shipyards, clustered along the waterfront. Subject to severed cyclical swings, shipbuilding was a highly skilled, unionised occupation. Many of those employed in port industries lived in London’s then quite socially mixed waterfront parishes of East London. Seamen ashore in colonial and foreign trades also gathered here in response to a sailor economy serving their need for credit, lodging and entertainment.
Nineteenth-century London was not only the greatest city ever known but it also had an immense port. Sarah Palmer explores how London’s maritime dimension, which included major industries, shaped London physically, economically, socially and profoundly affected the lives and livelihoods of many inhabitants. Until now, the relationship between London and its port has not been sufficiently explored by either the many London historians or by the relatively few historians of the Port of London. Port engineering, architecture, shipbuilding and port labour have received much attention, but are generally considered in isolation from the wider London context. She draws on such existing studies, as well as much new material based on archival research, to provide a wider perspective.
The East India Dock Company followed and by 1810, there were also three on the south bank. Investment came predominantly from the capital’s wealthy mercantile and shipping communities, with slave trade interests strongly represented in both the West India and London companies. Wartime conditions failed to affect investment or impede the capital’s remarkable dock boom. The design for the downriver West and East India systems presented few problems, unlike the constricted setting of the London Docks. Labour shortages, bad weather and material scarcity affected construction by generally experienced contractors, but all docks were operating by 1806. The final costs exceeded estimates but only in the case of the London Docks by a large margin. Clearing housing and industries in Wapping burdened it with long-term debt. All the north bank companies chose a hierarchical employment structure. In contrast to strict supervision in the West India Docks, London replicated the traditional system on the quays, allowing its managers considerable autonomy. In their new regulated workplace, labourers faced restrictions, discipline and the loss of traditional perks.
At mid-century, the north bank companies faced two main problems: wharf competition and the failure of earnings to keep pace with an increase in the shipping and cargoes handled. Adding to these challenges from the 1860s was accommodating steam shipping by investment in facilities, including new docks, and in the 1880s, a resurgence of fierce rivalry between themselves and a financial crisis created by the new Tilbury dock resulted in effective amalgamation. Their common response to diminishing profitability was the introduction of sub-contracting – to the detriment of the lives and livelihoods of a resistant workforce. Skilled port workers were unionised, unskilled generally not, but strikes by particular groups were not uncommon. Port-wide action by dock workers in the 1850s failed but stoppages in the early 1870s achieved wage rises, as also did the port-wide 1889 Great Dock Strike.
The 1866 banking crisis effectively ended London’s iron shipbuilding industry. Few companies survived, so destitution faced many shipyard workers. Processing industries also changed. Beet sugar replaced cane, soft sugar hard ‘baked’ sugar and production became concentrated in two firms. In contrast, boosted by foreign grain imports, London’s milling industry expanded. South bank maritime communities maintained established industrial patterns. Shipbuilding proved resilient and traditional employment systems persisted in the Rotherhithe docks, but settlements of waterfront wharf labourers, many of Irish origin, were desperately poor. Poverty was also a hallmark of the north bank. Less socially mixed than in the past, mythic undifferentiated images of ‘Outcast London’ obscured the East End’s continuing maritime connections, including the presence of skilled workers and their organisations. Sailors ashore, the subject of State intervention, were an exception.
Compensation was paid to river interests adversely affected, including some waterfront labourers, the State became owner of the Legal Quays until the 1830s, the Corporation built a canal across the Isle of Dogs, and a new London Bridge eventually replaced the Old. All this depended to some degree on State support; in the case of compensation payments, a Treasury loan was repaid by a tax on shipping. River port prosperity was largely unaffected by the introduction of docks, although their warehousing privileges deprived waterfront wharves of potential business. Coastal and low-duty European imports continued, boosted by the introduction of steamship services. Vessels carrying coal, grain, timber and provisions competed with passenger steamers and river traffic for water space, leading to conflict between users and with the Corporation as Harbour Authority.
After a few years of competition following the end of monopolies and exacerbated by the new St. Katharine’s Dock Company, rivalry was muted by rate agreements and the amalgamation of the East and West India Companies. However, except in the Baltic trade south bank docks, regional cargo specialisation to a large extent came to an end. All north bank companies had a core of permanent employees, but most were casually employed. Company records reveal how managers organised, motivated and disciplined their labouring workforce and also how those men with particular skills resisted such control. Relations with the Customs could also be difficult. In 1848, both the London and St. Katharine’s companies were raided, accused of defrauding the revenue by passing off sugar as waste. After a very public row, significant reputational damage to the companies and the intervention of a parliamentary committee, a compromise was reached.