This article argues that the spatial experiences created by the architectural features of Christian sacred spaces on the Roman frontiers of the fourth and fifth centuries were fundamental to how such spaces were perceived and engaged with. It suggests that the principles of spatial design established in Constantine’s basilicas of Rome and the Holy Land influenced the experience of Christian worship, ritual and commemoration on the Roman frontiers. While these frontier Christian sacred spaces generally followed the architectural trends of Constantinian models, they also showed distinct local adaptations. This study highlights the important role of architectural spatial design in shaping religious experiences on the Roman frontiers, illustrating the dynamic relationship between architecture, worship and regional cultural contexts. It shows both continuity with Constantinian norms and evidence of adaptability and localized expressions of Christian sacred architecture on the Roman empire’s peripheries.