2 results
Associations of antenatal glucocorticoid exposure with mental health in children
- Elina Wolford, Marius Lahti-Pulkkinen, Polina Girchenko, Jari Lipsanen, Soile Tuovinen, Jari Lahti, Kati Heinonen, Esa Hämäläinen, Eero Kajantie, Anu-Katriina Pesonen, Pia M. Villa, Hannele Laivuori, Rebecca M. Reynolds, Katri Räikkönen
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- Journal:
- Psychological Medicine / Volume 50 / Issue 2 / January 2020
- Published online by Cambridge University Press:
- 28 January 2019, pp. 247-257
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Background
Synthetic glucocorticoids, to enhance fetal maturation, are a standard treatment when preterm birth before 34 gestational weeks is imminent. While morbidity- and mortality-related benefits may outweigh potential neurodevelopmental harms in children born preterm (<37 gestational weeks), this may not hold true when pregnancy continues to term (⩾37 gestational weeks). We studied the association of antenatal betamethasone exposure on child mental health in preterm and term children.
MethodsWe included 4708 women and their children, born 2006–2010, from the Prediction and Prevention of Pre-eclampsia and Intrauterine Growth Restriction Study with information on both antenatal betamethasone treatment and child mental and behavioral disorders from the Finnish Hospital Discharge Register from the child's birth to 31 December 2016. Additional follow-up data on mother-reported psychiatric problems and developmental milestones were available for 2640 children at 3.5 (s.d. = 0.07) years-of-age.
ResultsOf the children, 187 were born preterm (61 betamethasone-exposed) and 4521 at term (56 betamethasone-exposed). The prevalence of any mental and behavioral, psychological development, emotional and behavioral, and comorbid disorders was higher in the betamethasone-exposed, compared to non-exposed children [odds ratio 2.76 (95% confidence interval 1.76–4.32), 3.61 (2.19–5.95), 3.29 (1.86–5.82), and 6.04 (3.25–11.27), respectively]. Levels of psychiatric problems and prevalence of failure to meet the age-appropriate development in personal-social skills were also higher in mother-reports of betamethasone-exposed children. These associations did not vary significantly between preterm and term children.
ConclusionsAntenatal betamethasone exposure may be associated with mental health problems in children born preterm and in those who end up being born at term.
Maternal early pregnancy obesity and depressive symptoms during and after pregnancy
- Satu M. Kumpulainen, Polina Girchenko, Marius Lahti-Pulkkinen, Rebecca M. Reynolds, Soile Tuovinen, Anu-Katriina Pesonen, Kati Heinonen, Eero Kajantie, Pia M. Villa, Esa Hämäläinen, Hannele Laivuori, Katri Räikkönen
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- Journal:
- Psychological Medicine / Volume 48 / Issue 14 / October 2018
- Published online by Cambridge University Press:
- 17 January 2018, pp. 2353-2363
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Background
Previous studies have linked maternal obesity with depressive symptoms during and after pregnancy. It remains unknown whether obesity associates with consistently elevated depressive symptoms throughout pregnancy, predicts symptoms postpartum when accounting for antenatal symptoms, and if co-morbid hypertensive and diabetic disorders add to these associations. We addressed these questions in a sample of Finnish women whom we followed during and after pregnancy.
MethodsEarly pregnancy body mass index, derived from the Finnish Medical Birth Register and hospital records in 3234 PREDO study participants, was categorized into underweight (<18.5 kg/m2), normal weight (18.5–24.99 kg/m2), overweight (25–29.99 kg/m2), and obese (⩾30 kg/m2) groups. The women completed the Center for Epidemiological Studies Depression Scale biweekly during pregnancy, and at 2.4 (s.d. = 1.2) and/or 28.2 (s.d. = 4.2) weeks after pregnancy.
ResultsIn comparison to normal weight women, overweight, and obese women reported higher levels of depressive symptoms and had higher odds of clinically significant depressive symptoms during (23% and 43%, respectively) and after pregnancy (22% and 36%, respectively). Underweight women had 68% higher odds of clinically significant depressive symptoms after pregnancy. Overweight and obesity also predicted higher depressive symptoms after pregnancy in women not reporting clinically relevant symptomatology during pregnancy. Hypertensive and diabetic disorders did not explain or add to these associations.
ConclusionsMaternal early pregnancy overweight and obesity and depressive symptoms during and after pregnancy are associated. Mental health promotion should be included as an integral part of lifestyle interventions in early pregnancy obesity and extended to benefit also overweight and underweight women.