In this paper I will offer some methodological reflections on legal science and its relations with the natural and human sciences. The first part of the paper (sections 2-4) deals with the relation between legal science and the natural sciences. The thesis I put forward is drawn from my book Teorie della scienza giuridica e teorie delle scienee naturali. Modelli e analogie, and restates the main points of my argument there against approaches founded on neopositivism and in favour of a post-positivist approach. The second part (sections 5-7) deals with some aspects of the relations between legal and human sciences, and develops some rather more tentative ideas which go beyond the conclusions reached in the book.