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Tetralogy of Fallot is a common CHD. Studies have shown a close link between heart failure and myocardial fibrosis. Interleukin-6 has been suggested to be a post-independent factor of heart failure. This study aimed to explore the relationship between IL-6 and myocardial fibrosis during cardiopulmonary bypass.
Material and Methods:
We downloaded the expression profile dataset GSE132176 from Gene Expression Omnibus. After normalising the raw data, Gene Set Enrichment Analysis and differential gene expression analysis were performed using R. Further, a weighted gene correlation network analysis and a protein–protein interaction network analysis were used to identify HUB genes. Finally, we downloaded single-cell expression data for HUB genes using PanglaoDB.
Results:
There were 119 differentially expressed genes in right atrium tissues comparing the post-CPB group with the pre-CPB group. IL-6 was found to be significantly up-regulated in the post-CPB group. Six genes (JUN, FOS, ATF3, EGR1, IL-6, and PTGS2) were identified as HUB genes by a weighted gene correlation network analysis and a protein–protein interaction network analysis. Gene Set Enrichment Analysis showed that IL-6 affects the myocardium during CPB mainly through the JAK/STAT signalling pathway. Finally, we used PanglaoDB data to analyse the single-cell expression of the HUB genes.
Conclusion:
Our findings suggest that high expression of IL-6 and the activation of the JAK/STAT signalling pathway during CPB maybe the potential mechanism of myocardial fibrosis. We speculate that the high expression of IL-6 might be an important factor leading to heart failure after ToF surgery. We expect that these findings will provide a basis for the development of targeted drugs.
We study an abstract second order inclusion involving two nonlinear single-valued operators and a nonlinear multi-valued term. Our goal is to establish the existence of solutions to the problem by applying numerical scheme based on time discretization. We show that the sequence of approximate solution converges weakly to a solution of the exact problem. We apply our abstract result to a dynamic, second-order-in-time differential inclusion involving a Clarke subdifferential of a locally Lipschitz, possibly non-convex and non-smooth potential. In the two presented examples the Clarke subdifferential appears either in a source term or in a boundary term.
In this paper, we study the problem of the existence of solutions for a class of fractional semilinear evolution inclusions with non-convex right-hand side. We mainly focus on the existence of the extreme solution and the relationship of the solution sets between the original problem and the convexified problem. An example is provided to illustrate the application of the obtained theory.
This paper investigates the existence of solutions for boundary variational–hemivariational inequalities of elliptic type at resonance as well as at non-resonance. Using the notion of the generalized gradient of Clarke and the property of the first eigenfunction, we also build a Landesman–Lazer theory in the non-smooth framework of variational–hemivariational inequalities of elliptic type.
This paper is devoted to the Dirichlet problem for quasilinear elliptic hemivariational inequalities at resonance as well as at non-resonance. Using Clarke's notion of the generalized gradient and the property of the first eigenfunction, we also build a Landesman–Lazer theory in the non-smooth framework of quasilinear elliptic hemivariational inequalities.
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