The increasing complexity and connectivity of the mobility system and modern automotive systems, particularly connected autonomous vehicles, demand a paradigm shift toward resilience-by-design to address disruptions in dynamic environments. Unlike established safety and cybersecurity engineering in automotive, resilience engineering has yet to be systematically integrated into development processes. This paper defines resilience using a standard-based definition method, emphasizing disruption tolerance, adaptability, and recoverability. We identify action fields to advance the topic and propose a resilience-by-design framework extending safety and cybersecurity perspectives. Resilience-by-design offers strategies and methods to design robust, adaptive systems, ensuring reliability and availability of automotive systems, functions, and components in operation.